Multi-biomarker Risk Stratification of Cystatin C, BNP and Cardiac Troponin T in Patients Hospitalized for Worsening Chronic Heart Failure

2006 ◽  
Vol 12 (8) ◽  
pp. S175-S176
Author(s):  
Hiroyuki Naruse ◽  
Junnichi Ishii ◽  
Masanori Okumura ◽  
Tadashi Nakano ◽  
Yoshihisa Mori ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Risk Stratification ◽  
Cystatin C ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T

scholarly journals Prognostic Value of Combination of Cardiac Troponin T and B-Type Natriuretic Peptide after Initiation of Treatment in Patients with Chronic Heart Failure

2003 ◽  
Vol 49 (12) ◽  
pp. 2020-2026 ◽  
Author(s):  
Junnichi Ishii ◽  
Wei Cui ◽  
Fumihiko Kitagawa ◽  
Takahiro Kuno ◽  
Yuu Nakamura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Myocardial Damage ◽  
Left Ventricular ◽  
Functional Class ◽  
Cardiac Troponin T ◽  
Cardiac Events ◽  
Nyha Functional Class

Abstract Background: Recent studies have suggested that cardiac troponin T (cTnT) and troponin I may detect ongoing myocardial damage involved in the progression of chronic heart failure (CHF). This study was prospectively designed to examine whether the combination of cTnT, a marker for ongoing myocardial damage, and B-type natriuretic peptide (BNP), a marker for left ventricular overload, would effectively stratify patients with CHF after initiation of treatment. Methods: We measured serum cTnT, plasma BNP, and left ventricular ejection fraction (LVEF) on admission for worsening CHF [New York Heart Association (NYHA) functional class III to IV] and 2 months after initiation of treatment to stabilize CHF (n = 100; mean age, 68 years). Results: Mean (SD) concentrations of cTnT [0.023 (0.066) vs 0.063 (0.20) μg/L] and BNP [249 (276) vs 753 (598) ng/L], percentage increased cTnT (>0.01 μg/L; 35% vs 60%), NYHA functional class [2.5 (0.6) vs 3.5 (5)], and LVEF [43 (13)% vs 36 (12)%] were significantly (P <0.01) improved 2 months after treatment compared with admission. During a mean follow-up of 391 days, there were 44 cardiac events, including 12 cardiac deaths and 32 readmissions for worsening CHF. On a stepwise Cox regression analysis, increased cTnT and BNP were independent predictors of cardiac events (P <0.001). cTnT >0.01 μg/L and/or BNP >160 ng/L 2 months after initiation of treatment were associated with increased cardiac mortality and morbidity rates. Conclusion: The combination of cTnT and BNP measurements after initiation of treatment may be highly effective for risk stratification in patients with CHF.

P-65 Relationship Between Renal Function and Serum Cardiac Troponin T in Patients with Chronic Heart Failure

2009 ◽  
Vol 4 ◽  
pp. S70
Author(s):  
Chiho Kawahara ◽  
Takayoshi Tsutamoto ◽  
Masayuki Yamaji ◽  
Keizo Nishiyama ◽  
Takashi Yamamoto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Chronic Heart Failure ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Serum Cardiac Troponin

Utility of Highly Sensitive Cardiac Troponin T Assay on Discharge in Patients With Chronic Heart Failure

2009 ◽  
Vol 15 (7) ◽  
pp. S163-S164
Author(s):  
Tousei Hashimoto ◽  
Junntichi Ishii ◽  
Shigeru Matsui ◽  
Hiroyuki Naruse ◽  
Tadashi Nakano ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Highly Sensitive

Clinical significance of elevated levels of cardiac troponin T in patients with chronic heart failure

1999 ◽  
Vol 84 (5) ◽  
pp. 608-611 ◽  
Author(s):  
Koichi Setsuta ◽  
Yoshihiko Seino ◽  
Naoto Takahashi ◽  
Takeshi Ogawa ◽  
Kenji Sasaki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Clinical Significance ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T

scholarly journals Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure

2009 ◽  
Vol 11 (7) ◽  
pp. 653-658 ◽  
Author(s):  
Takayoshi Tsutamoto ◽  
Chiho Kawahara ◽  
Masayuki Yamaji ◽  
Keizo Nishiyama ◽  
Masanori Fujii ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Chronic Heart Failure ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Serum Cardiac Troponin
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