Matrix Metalloproteinases and Their Endogenous Inhibitors: Association with Ventricular Remodeling, Diastolic Dysfunction and Heart Failure in the Community

2006 ◽  
Vol 12 (6) ◽  
pp. S32
Author(s):  
Carolyn S.P. Lam ◽  
Richard J. Rodeheffer ◽  
John C. Burnett ◽  
Margaret M. Redfield
Keyword(s):  
Heart Failure ◽  
Matrix Metalloproteinases ◽  
Diastolic Dysfunction ◽  
Ventricular Remodeling ◽  
Endogenous Inhibitors

Interactive role of diastolic dysfunction and ventricular remodeling in asymptomatic subjects at increased risk of heart failure

2019 ◽  
Vol 35 (7) ◽  
pp. 1231-1240 ◽  
Author(s):  
Iacopo Fabiani ◽  
◽  
Nicola Riccardo Pugliese ◽  
Salvatore La Carrubba ◽  
Lorenzo Conte ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diastolic Dysfunction ◽  
Ventricular Remodeling ◽  
Increased Risk ◽  
Asymptomatic Subjects

Abstract 2845: Differential Impact of Left Ventricular Remodeling on Septal and Lateral E/Ea Ratio in Predicting Diastolic Staging in Chronic Systolic Heart Failure

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
W. H. Wilson Tang ◽  
Kevin Shrestha ◽  
Wilfried Mullens ◽  
Allen Borowski ◽  
Richard W Troughton ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diastolic Dysfunction ◽  
Ventricular Remodeling ◽  
Diastolic Heart Failure ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Doppler Velocity ◽  
Left Ventricular Volumes ◽  
2D Echocardiography ◽  
Chronic Systolic Heart Failure

Background: The ratio of peak transmitral pulsed Doppler early velocity to early diastolic tissue Doppler velocity of the lateral or septal mitral annulus (E/Ea) is considered a reliable estimation of diastolic dysfunction, and their average has been incorporated as clinical determinant of diastolic heart failure. Their relative relaibility in the setting pf left ventricular volumes has not been established. Methods: We performed comprehensive 2D echocardiography in 214 ambulatory patients with chronic systolic heart failure (LVEF ≤35%, NYHA II-III). Diastolic staging was determined from patterns of transmitral and pulmonary vein flows. Results: In our study population (mean age 57 years, 73% male mean left ventricular end-diastolic volume [LVEDV] 228 ml, mean LVEF 25%) , the median lateral and septal Ea were 6.9 cm/s and 4.5 cm/s, respectively. The median E/lateral Ea, E/septal Ea, and E/average Ea [inter-quartile range] were 10.8 [7.1–15.1], 16.1 [11.1–23.0], and 12.7 [8.8–17.7], respectively. In the first two tertiles of indexed LVEDV (LVEDVi<92.6 ml/m 2 and 92.6–129.5 ml/m 2 ), all three E/Ea indices increased with increasing diastolic stages (all p<0.001). However, in the highest tertile of LVEDVi (>129.5 ml/m 2 ), E/septal Ea (but not E/lateral Ea) increased with increasing diastolic stages (Figure ). Conclusions: Unlike E/septal Ea, E/lateral Ea did not increase with increasing diastolic stage in patients with chronic systolic heart failure presenting with LV dilatation. These observations may suggest that the E/septal Ea measurements may be more reliable than E/lateral Ea to assess diastolic dysfunction in patients with enlarged ventricles.

scholarly journals Activation of Matrix Metalloproteinases Precedes Left Ventricular Remodeling in Hypertensive Heart Failure Rats

Circulation ◽  
2004 ◽  
Vol 109 (17) ◽  
pp. 2143-2149 ◽  
Author(s):  
Yasushi Sakata ◽  
Kazuhiro Yamamoto ◽  
Toshiaki Mano ◽  
Nagahiro Nishikawa ◽  
Junichi Yoshida ◽  
...  
Keyword(s):  
Heart Failure ◽  
Matrix Metalloproteinases ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular

142 Utility of BNP in detecting diastolic dysfunction in chronic heart failure patients

2003 ◽  
Vol 2 (1) ◽  
pp. 23-24
Author(s):  
A SCARDOVI ◽  
C COLETTA ◽  
N ASPROMONTE ◽  
A SESTILI ◽  
M RENZI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Diastolic Dysfunction ◽  
Heart Failure Patients
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