Decreased Myocardial Free Fatty Acid Uptake in Patients With Idiopathic Dilated Cardiomyopathy: Evidence of Relationship With Insulin Resistance and Left Ventricular Dysfunction

2006 ◽  
Vol 12 (8) ◽  
pp. 644-652 ◽  
Author(s):  
Helena Tuunanen ◽  
Erik Engblom ◽  
Alexandru Naum ◽  
Mika Scheinin ◽  
Kjell Någren ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Dilated Cardiomyopathy ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Fatty Acid Uptake ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Acid Uptake

scholarly journals Recurrence of Left Ventricular Dysfunction in Patients With Restored Idiopathic Dilated Cardiomyopathy

2014 ◽  
Vol 37 (4) ◽  
pp. 222-226 ◽  
Author(s):  
Jin-Sun Park ◽  
Jin-Woo Kim ◽  
Kyoung-Woo Seo ◽  
Byoung-Joo Choi ◽  
So-Yeon Choi ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy

scholarly journals Effect of Weight Loss on Liver Free Fatty Acid Uptake and Hepatic Insulin Resistance

2009 ◽  
Vol 94 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Antti P. M. Viljanen ◽  
Patricia Iozzo ◽  
Ronald Borra ◽  
Mikko Kankaanpää ◽  
Anna Karmi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fatty Acid Uptake ◽  
Fat Content ◽  
Liver Fat ◽  
Hepatic Insulin Resistance ◽  
Acid Uptake ◽  
Liver Fat Content

Abstract Objective: Weight loss has been shown to decrease liver fat content and whole-body insulin resistance. The current study was conducted to investigate the simultaneous effects of rapid weight reduction with a very-low-calorie diet on liver glucose and fatty acid metabolism and liver adiposity. Hypothesis: We hypothesized that liver insulin resistance and free fatty acid uptake would decrease after weight loss and that they are associated with reduction of liver fat content. Design: Thirty-four healthy obese subjects (body mass index, 33.7 ± 8.0 kg/m2) were studied before and after a very-low-calorie diet for 6 wk. Hepatic glucose uptake and endogenous glucose production were measured with [18F]fluorodeoxyglucose during hyperinsulinemic euglycemia and fasting hepatic fatty acid uptake with [18F]fluoro-6-thia-heptadecanoic acid and positron emission tomography. Liver volume and fat content were measured using magnetic resonance imaging and spectroscopy. Results: Subjects lost weight (11.2 ± 2.9 kg; P < 0.0001). Liver volume decreased by 11% (P < 0.002), which was partly explained by decreased liver fat content (P < 0.0001). Liver free fatty acid uptake was 26% lower after weight loss (P < 0.003) and correlated with the decrement in liver fat content (r = 0.54; P < 0.03). Hepatic glucose uptake during insulin stimulation was unchanged, but the endogenous glucose production decreased by 40% (P < 0.04), and hepatic insulin resistance by 40% (P < 0.05). Conclusions: The liver responds to a 6-wk period of calorie restriction with a parallel reduction in lipid uptake and storage, accompanied by enhancement of hepatic insulin sensitivity and clearance.

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