Homeobox genes in cardiac development

Don Chen; Andrew Greene; Xiaoqin Qu; Mario C. Deng; Hal A. Skopicki

doi:10.1016/j.cardfail.2004.06.147

Homeobox genes in cardiac development

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2004.06.147 ◽

2004 ◽

Vol 10 (4) ◽

pp. S59

Author(s):

Don Chen ◽

Andrew Greene ◽

Xiaoqin Qu ◽

Mario C. Deng ◽

Hal A. Skopicki

Keyword(s):

Cardiac Development ◽

Homeobox Genes

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Homeobox Genes and Homeodomain Proteins: New Insights into Cardiac Development, Degeneration and Regeneration

Advances in Experimental Medicine and Biology - Cell Biology and Translational Medicine, Volume 6 ◽

10.1007/5584_2019_349 ◽

2019 ◽

pp. 155-178 ◽

Cited By ~ 2

Author(s):

Rokas Miksiunas ◽

Ali Mobasheri ◽

Daiva Bironaite

Keyword(s):

Cardiac Development ◽

Homeobox Genes ◽

Homeodomain Proteins

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Nkx2.5 and Nkx2.6, Homologs ofDrosophila tinman, Are Required for Development of the Pharynx

Molecular and Cellular Biology ◽

10.1128/mcb.21.13.4391-4398.2001 ◽

2001 ◽

Vol 21 (13) ◽

pp. 4391-4398 ◽

Cited By ~ 55

Author(s):

Makoto Tanaka ◽

Martina Schinke ◽

Hai-Sun Liao ◽

Naohito Yamasaki ◽

Seigo Izumo

Keyword(s):

Double Mutant ◽

Cardiac Development ◽

Critical Role ◽

Homeobox Genes ◽

Mutant Mice ◽

Ventral Region ◽

Early Stages ◽

Endodermal Cells

ABSTRACT Nkx2.5 and Nkx2.6 are murine homologs of Drosophilatinman. Their genes are expressed in the ventral region of the pharynx at early stages of embryogenesis. However, no abnormalities in the pharynges of embryos with mutations in either Nkx2.5 or Nkx2.6 have been reported. To examine the function of Nkx2.5 and Nkx2.6 in the formation of the pharynx, we generated and analyzed Nkx2.5 and Nkx2.6 double-mutant mice. Interestingly, in the double-mutant embryos, the pharynx did not form properly. Pharyngeal endodermal cells were largely missing, and the mutant pharynx was markedly dilated. Moreover, we observed enhanced apoptosis and reduced proliferation in pharyngeal endodermal cells of the double-mutant embryos. These results demonstrated a critical role of the NK-2 homeobox genes in the differentiation, proliferation, and survival of pharyngeal endodermal cells. Furthermore, the development of the atrium was less advanced in the double-mutant embryos, indicating that these two genes are essential for both pharyngeal and cardiac development.

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