Aldosterone directly stimulates cardiac myocyte hypertrophy

2004 ◽  
Vol 10 (6) ◽  
pp. 511-518 ◽  
Author(s):  
Marina P. Okoshi ◽  
Xinhua Yan ◽  
Katashi Okoshi ◽  
Masaharu Nakayama ◽  
Adam J.T. Schuldt ◽  
...  
Keyword(s):  
Cardiac Myocyte ◽  
Myocyte Hypertrophy ◽  
Cardiac Myocyte Hypertrophy

Heart Fatty Acid Binding Protein Is a Novel Regulator of Cardiac Myocyte Hypertrophy

1994 ◽  
Vol 205 (3) ◽  
pp. 1822-1828 ◽  
Author(s):  
P.B.J. Burton ◽  
C.E. Hogben ◽  
C.L. Joannou ◽  
A.G.B. Clark ◽  
J.J. Hsuan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Cardiac Myocyte ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Myocyte Hypertrophy ◽  
Acid Binding Protein ◽  
Cardiac Myocyte Hypertrophy

scholarly journals P126The role of MIP1 in cardiac myocyte hypertrophy and survival

2014 ◽  
Vol 103 (suppl 1) ◽  
pp. S22.2-S22
Author(s):  
C Mansfield ◽  
B Buyandelger ◽  
S Kostin ◽  
G Knoell ◽  
MR Toliat ◽  
...  
Keyword(s):  
Cardiac Myocyte ◽  
Myocyte Hypertrophy ◽  
Cardiac Myocyte Hypertrophy

Sphingolipids induce cardiac myocyte hypertrophy through Gi protein-coupled receptor and MAPK cascade

1999 ◽  
Vol 5 (3) ◽  
pp. 78
Author(s):  
Kenichi Sekiguchi ◽  
Tomoyuki Yokoyama ◽  
Masashi Arai ◽  
Masahiko Kurabayashi ◽  
Ryozo Nagai
Keyword(s):  
Cardiac Myocyte ◽  
Mapk Cascade ◽  
Myocyte Hypertrophy ◽  
Gi Protein ◽  
Cardiac Myocyte Hypertrophy

scholarly journals Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy

2020 ◽  
Vol 79 ◽  
pp. 108339 ◽  
Author(s):  
Levi W. Evans ◽  
Abigail Bender ◽  
Leah Burnett ◽  
Luis Godoy ◽  
Yi Shen ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Cardiac Myocyte ◽  
Hdac Activity ◽  
Myocyte Hypertrophy ◽  
Cardiac Myocyte Hypertrophy

Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo

1996 ◽  
Vol 271 (6) ◽  
pp. H2197-H2208 ◽  
Author(s):  
J. Lai ◽  
H. Jin ◽  
R. Yang ◽  
J. Winer ◽  
W. Li ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Cardiac Myocyte ◽  
Ventricular Myocytes ◽  
Chronic Administration ◽  
Heart Weight ◽  
Adult Rats ◽  
Myocyte Hypertrophy ◽  
Cardiac Myocyte Hypertrophy

Several prostaglandins [prostaglandin (PG) A2, -B2, -D2, -E2, -F2 alpha, and -I2 and carbaprostacyclin] and the thromboxane analogue U-46619 were analyzed for the ability to induce hypertrophy of rat neonatal cardiac ventricular myocytes. Myocyte hypertrophy was induced specifically by PGF2 alpha. Myocytes exposed to this prostanoid in culture increased in size and protein content. The contractile fibrils within the cells became organized into parallel arrays, and the cells tended to cluster and beat spontaneously. PGF2 alpha also induced the expression of c-fos, atrial natriuretic factor (ANF), and alpha-skeletal actin in these cells. The effects of PGF2 alpha were compared with several known cardiac myocyte hypertrophy factors (phenylephrine, endothelin-1, leukemia inhibitory factor, cardiotrophin-1, and angiotensin II). PGF2 alpha was found to be intermediate in potency among the factors but induced a level of ANF production that was approximately 10-fold higher than any of the other effectors. Responsiveness to PGF2 alpha was not limited to neonatal cardiocytes. Ventricular myocytes isolated from adult rats also responded specifically to PGF2 alpha with a morphological change similar to that observed with phenylephrine and by producing ANF. In rats, chronic administration of fluprostenol, a potent agonist analogue of PGF2 alpha, resulted in a dose-dependent increase in heart weight- and ventricular weight-to-body weight ratios. The amount of PGF2 alpha extractable from the hearts of rats with cardiac hypertrophy induced by myocardial infarction was also found to be greater than that in sham-operated control rats. These results indicate that PGF2 alpha may play an important role in inducing cardiac hypertrophy.

Sign in / Sign up

Export Citation Format

Share Document