Highly integrated plasmonic sensor design for the simultaneous detection of multiple analytes

2020 ◽  
Vol 20 (11) ◽  
pp. 1274-1280 ◽  
Author(s):  
M.A. Butt ◽  
N.L. Kazanskiy ◽  
S.N. Khonina
Keyword(s):  
Simultaneous Detection ◽  
Sensor Design ◽  
Plasmonic Sensor ◽  
Multiple Analytes

scholarly journals A Numerical Investigation of a Plasmonic Sensor Based on a Metal-Insulator-Metal Waveguide for Simultaneous Detection of Biological Analytes and Ambient Temperature

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2551
Author(s):  
Nikolay L. Kazanskiy ◽  
Svetlana N. Khonina ◽  
Muhammad A. Butt ◽  
Andrzej Kaźmierczak ◽  
Ryszard Piramidowicz
Keyword(s):  
Ambient Temperature ◽  
Simultaneous Detection ◽  
Resonance Wavelength ◽  
Temperature Sensing ◽  
Sensor Design ◽  
Plasmonic Sensor ◽  
Metal Insulator ◽  
Sensing Applications ◽  
Metal Insulator Metal ◽  
Biological Analytes

A multipurpose plasmonic sensor design based on a metal-insulator-metal (MIM) waveguide is numerically investigated in this paper. The proposed design can be instantaneously employed for biosensing and temperature sensing applications. The sensor consists of two simple resonant cavities having a square and circular shape, with the side coupled to an MIM bus waveguide. For biosensing operation, the analytes can be injected into the square cavity while a thermo-optic polymer is deposited in the circular cavity, which provides a shift in resonance wavelength according to the variation in ambient temperature. Both sensing processes work independently. Each cavity provides a resonance dip at a distinct position in the transmission spectrum of the sensor, which does not obscure the analysis process. Such a simple configuration embedded in the single-chip can potentially provide a sensitivity of 700 nm/RIU and −0.35 nm/°C for biosensing and temperature sensing, respectively. Furthermore, the figure of merit (FOM) for the biosensing module and temperature sensing module is around 21.9 and 0.008, respectively. FOM is the ratio between the sensitivity of the device and width of the resonance dip. We suppose that the suggested sensor design can be valuable in twofold ways: (i) in the scenarios where the testing of the biological analytes should be conducted in a controlled temperature environment and (ii) for reducing the influence on ambient temperature fluctuations on refractometric measurements in real-time mode.

A new DNA sensor design for the simultaneous detection of HPV type 16 and 18 DNA

2018 ◽  
Vol 265 ◽  
pp. 514-521 ◽  
Author(s):  
Sakda Jampasa ◽  
Weena Siangproh ◽  
Rawiwan Laocharoensuk ◽  
Pattamawadee Yanatatsaneejit ◽  
Tirayut Vilaivan ◽  
...  
Keyword(s):  
Simultaneous Detection ◽  
Sensor Design ◽  
Dna Sensor

Development of All-Plastic Microvalve Array for Multiplexed Immunoassay

2014 ◽  
Author(s):  
Shancy Augustine ◽  
Pan Gu ◽  
Xiangjun Zheng ◽  
Toshikazu Nishida ◽  
Z. Hugh Fan
Keyword(s):  
Large Scale ◽  
Low Cost ◽  
Simultaneous Detection ◽  
Cost Effective ◽  
Negative Control ◽  
Sensitive Material ◽  
Detection Scheme ◽  
Power Battery ◽  
Multiple Analytes ◽  
Multiplexed Immunoassay

There is a need for low-cost immunoassays that measure the presence and concentration of multiple harmful agents in one device. Currently, comparable immunoassays employ a one-analyte-per-test format that is time consuming and not cost effective for the requirement of detecting multiple analytes in a single sample. For instance, if a spectrum of harmful agents, including E. coli O157, cholera toxin, and Salmonella typhimurium, should be simultaneously monitored in foods and drinking water, then a one-analyte-per-test would be inefficient. This work demonstrates a platform capable of simultaneous detection of multiple analytes in a single, low-cost, microvalve array-enabled multiplexed immunoassay. This multiplexed immunoassay platform is demonstrated in a prototype COC (cyclic olefin copolymer) device with a 2×3 array in which 6 analytes can be detected simultaneously. In order to contain and regulate the flow of reagents in the multichannel device, an array of microfluidic valves actuated by a thermally expandable material and microfabricated resistors have been developed to direct the flow to the necessary assay sites. The microvalve-based immunoassay is shown to be reliable, easy to operate, and compatible with large-scale integration. The all-plastic microvalves use paraffin wax as the thermally sensitive material which drastically reduces power consumption by latching upon closing so that pulsed power is required only to close and latch the microvalve until it is necessary to re-open the valve. The multiplexed detection scheme has been demonstrated by using three proteins, C reactive protein (CRP) and transferrin, both of which are biomarkers associated with traumatic brain injury (TBI) as well as bovine serum albumin (BSA) as the negative control. Since there are no external bulky pneumatic accessories required to operate/latch the microvalves in the device, this compact, thermally actuated and latching microvalve-enabled multiplexed immunoassay has the potential to realize a portable, low power, battery operated microfluidic device for biological assays.

Array Biosensor for Simultaneous Detection of Multiple Analytes

2000 ◽  
pp. 7-15
Author(s):  
Frances S. Ligler ◽  
James W. Hazzard ◽  
Joel P. Golden ◽  
Chris A. Rowe
Keyword(s):  
Simultaneous Detection ◽  
Array Biosensor ◽  
Multiple Analytes

scholarly journals Protocell Arrays for Simultaneous Detection of Diverse Analytes

2021 ◽  
Author(s):  
Yan Zhang ◽  
Taisuke Kojima ◽  
Ge-Ah Kim ◽  
Monica P. McNerney ◽  
Shuichi Takayama ◽  
...  
Keyword(s):  
Small Molecules ◽  
Simultaneous Detection ◽  
Sample Volume ◽  
Free Expression ◽  
Phase System ◽  
Two Phase ◽  
Complex Decision Making ◽  
Multiple Analytes ◽  
Complex Decision ◽  
Analyte Detection

AbstractSimultaneous detection of multiple analytes from a single sample (multiplexing), particularly when at the point of need, can guide complex decision-making without increasing the required sample volume or cost per test. Despite recent advances, multiplexing still typically faces the critical limitation of measuring only one type of molecule per assay platform – for example, only small molecules or only nucleic acids. In this work, we address this bottleneck with a customizable platform that integrates cell-free expression (CFE) with a polymer-based aqueous two-phase system (ATPS) to produce membrane-less “protocells” containing transcription and translation machinery used for analyte detection. Multiple protocells are arrayed in microwells where each protocell droplet performs distinct reactions to detect chemically diverse targets including small molecules, minerals, and nucleic acid sequences, all from the same sample. We demonstrate that these protocell arrays can measure analytes in a human biofluid matrix, maintain function after lyophilization and rehydration, and produce visually interpretable readouts, illustrating its potential for application as a minimal-equipment, field-deployable, multi-analyte detection tool.

Comparative study of the highly sensitive plasmonic sensor based on a D-Shaped photonic crystal fiber with silver or gold layers

2021 ◽  
Author(s):  
Bahar Meshginqalam ◽  
Jamal Barvestani
Keyword(s):  
Photonic Crystal ◽  
Comparative Study ◽  
Photonic Crystal Fiber ◽  
Structural Parameters ◽  
Simultaneous Detection ◽  
Plasmonic Sensor ◽  
Plasmonic Material ◽  
Sensor Performance ◽  
Crystal Fiber ◽  
Highly Sensitive

Abstract A highly sensitive D-shaped photonic crystal fiber sensor with circular lattice is proposed for external plasmonic sensing. The proposed design of plasmonic material in a D-shaped form effectively facilitates the excitation of surface plasmons and enhances the sensor performance. As a comparative study, two different plasmonic materials, gold and silver, are applied D-shapely on the fiber and the proposed sensor performance is numerically investigated and evaluated. Moreover, the optimized structural parameters such as air-hole diameters and the thickness of silver and gold layers are selected via simulation results which cause the highest sensitivity of 40000nm/RIU for the gold coated fiber using the wavelength interrogation method. Furthermore, the maximum figure of merit can reach 621.50RIU-1. Analytes with the refractive indices ranging from 1.34 to 1.39 can be detected by double-loss peak that is a more reliable method of simultaneous detection and verification of sensing characteristics. Due to its promising results, the proposed sensor can be widely useful in the area of chemical and biological sensing.

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