Magnetic resonance tracking of multifunctional nanoparticle-labeled mouse mesenchymal stem cells in a mouse model of myocardial infarction

2009 ◽  
Vol 9 (1) ◽  
pp. S12-S14 ◽  
Author(s):  
Kyuhong Lee ◽  
Cheongsoo Park ◽  
Hye-Young Moon ◽  
Eunjung Ahn ◽  
Hyo Eun Park ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Multifunctional Nanoparticle

scholarly journals CD271+ Human Mesenchymal Stem Cells Show Antiarrhythmic Effects in a Novel Murine Infarction Model

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1474 ◽  
Author(s):  
Haval Sadraddin ◽  
Ralf Gaebel ◽  
Anna Skorska ◽  
Cornelia Aquilina Lux ◽  
Sarah Sasse ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Ischemia Reperfusion ◽  
Human Mesenchymal Stem Cells ◽  
Antiarrhythmic Effect ◽  
Time Required ◽  
Antiarrhythmic Effects

Background: Ventricular arrhythmias (VA) are a common cause of sudden death after myocardial infarction (MI). Therefore, developing new therapeutic methods for the prevention and treatment of VA is of prime importance. Methods: Human bone marrow derived CD271+ mesenchymal stem cells (MSC) were tested for their antiarrhythmic effect. This was done through the development of a novel mouse model using an immunocompromised Rag2−/− γc−/− mouse strain subjected to myocardial “infarction-reinfarction”. The mice underwent a first ischemia-reperfusion through the left anterior descending (LAD) artery closure for 45 min with a subsequent second permanent LAD ligation after seven days from the first infarct. Results: This mouse model induced various types of VA detected with continuous electrocardiogram (ECG) monitoring via implanted telemetry device. The immediate intramyocardial delivery of CD271+ MSC after the first MI significantly reduced VA induced after the second MI. Conclusions: In addition to the clinical relevance, more closely reflecting patients who suffer from severe ischemic heart disease and related arrhythmias, our new mouse model bearing reinfarction warrants the time required for stem cell engraftment and for the first time enables us to analyze and verify significant antiarrhythmic effects of human CD271+ stem cells in vivo.

Magnetic Resonance Evaluation of Transplanted Mesenchymal Stem Cells After Myocardial Infarction in Swine

2011 ◽  
Vol 27 (6) ◽  
pp. 818-825 ◽  
Author(s):  
Ke Yang ◽  
Peng Xiang ◽  
Chengxi Zhang ◽  
Liyuan Zou ◽  
Xiao Wu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Magnetic Resonance

scholarly journals In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction

Circulation ◽  
2003 ◽  
Vol 107 (18) ◽  
pp. 2290-2293 ◽  
Author(s):  
Dara L. Kraitchman ◽  
Alan W. Heldman ◽  
Ergin Atalar ◽  
Luciano C. Amado ◽  
Bradley J. Martin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Magnetic Resonance ◽  
Resonance Imaging

TU-D-352-02: Magnetic Resonance Imaging to Track Mesenchymal Stem Cells (MSCs) in a Murine Myocardial Infarction Model

2008 ◽  
Vol 35 (6Part21) ◽  
pp. 2898-2898
Author(s):  
Y Yang ◽  
Y Yang ◽  
B Klein ◽  
N Yanasak ◽  
X Shi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Magnetic Resonance ◽  
Resonance Imaging
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