scholarly journals AFP mRNA level in enriched circulating tumor cells from hepatocellular carcinoma patient blood samples is a pivotal predictive marker for metastasis

2016 ◽  
Vol 378 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Junhua Jin ◽  
Xiaojuan Niu ◽  
Lihui Zou ◽  
Lin Li ◽  
Shugang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Mrna Level ◽  
Predictive Marker ◽  
Blood Samples ◽  
Carcinoma Patient ◽  
Afp Mrna

scholarly journals Clearance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection or Liver Transplantation

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2476
Author(s):  
Víctor Amado ◽  
Sandra González-Rubio ◽  
Javier Zamora ◽  
Rafael Alejandre ◽  
María Lola Espejo-Cruz ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Surgical Resection ◽  
Tumor Recurrence ◽  
Surrogate Marker ◽  
Blood Samples ◽  
Prospective Pilot Study

Background: In patients with hepatocellular carcinoma (HCC), a complete clearance of circulating tumor cells (CTCs) early after liver transplantation (LT) or surgical resection (LR) could prevent tumor recurrence. Methods: prospective pilot study including patients with HCC who underwent LR or LT from September 2017 to May 2020. Enumeration of CTCs was performed in peripheral blood samples (7 mL) using the Isoflux® system (Fluxion Biosciences) immediately before surgery, at post-operative day 5 and at day 30. A clinically relevant number of CTCs was defined as >30 CTCs/sample. Results: 41 HCC patients were included (mean age 58.7 ± 6.3; 82.9% male). LR was performed in 10 patients (24.4%) and 31 patients (75.6%) underwent LT. The main etiology of liver disease was chronic hepatitis C (31.7%). Patients undergoing LR and LT were similar in terms of preoperative CTC count (p = 0.99), but clearance of CTCs within the first month was more pronounced in the LT group. Clusters of CTCs at baseline were associated with incomplete clearance of CTCs at day 30 (54.2% vs. 11.8%, p = 0.005), which in turn impacted negatively on survival (p = 0.038). Conclusion: Incomplete clearance of CTCs after surgery could be a surrogate marker of HCC aggressiveness.

scholarly journals Isolation of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Using a Novel Cell Separation Strategy

2011 ◽  
Vol 17 (11) ◽  
pp. 3783-3793 ◽  
Author(s):  
Wen Xu ◽  
Lu Cao ◽  
Lei Chen ◽  
Jing Li ◽  
Xiao-Feng Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Separation ◽  
Separation Strategy

scholarly journals Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Jing-jing Yu ◽  
Wei Xiao ◽  
Shui-lin Dong ◽  
Hui-fang Liang ◽  
Zhi-wei Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Tumor Cells ◽  
Circulating Tumor Cells

scholarly journals Finding the seed of recurrence: Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment

2021 ◽  
Vol 13 (9) ◽  
pp. 967-978
Author(s):  
Francesca Carissimi ◽  
Matteo Nazzareno Barbaglia ◽  
Livia Salmi ◽  
Cristina Ciulli ◽  
Linda Roccamatisi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Treatment ◽  
Tumor Cells ◽  
Circulating Tumor Cells

Ezrin-polarized circulating tumor cells as a potential biomaker in hepatocellular carcinoma

2021 ◽  
Author(s):  
M Juratli ◽  
S Sliwinski ◽  
E Oppermann ◽  
A Lorentzen ◽  
A Pascher ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Cells ◽  
Circulating Tumor Cells
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