Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells

2016 ◽  
Vol 375 (1) ◽  
pp. 127-132 ◽  
Author(s):  
Steve Gerges ◽  
Katharina Rohde ◽  
Simone Fulda
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Demethylating Agents ◽  
Cell Death Pathways ◽  
Smac Mimetics

scholarly journals Inhibition of Autophagy Enhances the Antitumor Effect of Thioridazine in Acute Lymphoblastic Leukemia Cells

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 365
Author(s):  
Carina Colturato-Kido ◽  
Rayssa M. Lopes ◽  
Hyllana C. D. Medeiros ◽  
Claudia A. Costa ◽  
Laura F. L. Prado-Souza ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Clinical Problem ◽  
Jurkat Cells ◽  
Leukemia Cells ◽  
Peripheral Mononuclear Blood ◽  
Induced Apoptosis ◽  
Cure Rates

Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the development of new therapeutic strategies and drugs to improve the disease outcome. Antipsychotic phenothiazines have emerged as potential candidates to be repositioned as antitumor drugs. It was previously shown that the anti-histaminic phenothiazine derivative promethazine induced autophagy-associated cell death in chronic myeloid leukemia cells, although autophagy can act as a “double-edged sword” contributing to cell survival or cell death. Here we evaluated the role of autophagy in thioridazine (TR)-induced cell death in the human ALL model. TR induced apoptosis in ALL Jurkat cells and it was not cytotoxic to normal peripheral mononuclear blood cells. TR promoted the activation of caspase-8 and -3, which was associated with increased NOXA/MCL-1 ratio and autophagy triggering. AMPK/PI3K/AKT/mTOR and MAPK/ERK pathways are involved in TR-induced cell death. The inhibition of the autophagic process enhanced the cytotoxicity of TR in Jurkat cells, highlighting autophagy as a targetable process for drug development purposes in ALL.

scholarly journals 3D/4D multiscale imaging in acute lymphoblastic leukemia cells-visualizing dynamics of cell death

2017 ◽  
Author(s):  
Sreelatha Sarangapani ◽  
Rosmin Elsa Mohan ◽  
Ajeetkumar Patil ◽  
Matthew J. Lang ◽  
Anand Asundi
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Multiscale Imaging

scholarly journals CD 47 agonist peptide PKHB 1 induces immunogenic cell death in T‐cell acute lymphoblastic leukemia cells

2018 ◽  
Vol 110 (1) ◽  
pp. 256-268 ◽  
Author(s):  
Ashanti Concepción Uscanga‐Palomeque ◽  
Kenny Misael Calvillo‐Rodríguez ◽  
Luis Gómez‐Morales ◽  
Eva Lardé ◽  
Thomas Denèfle ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Immunogenic Cell Death ◽  
Agonist Peptide ◽  
Cell Acute Lymphoblastic Leukemia

PI3K-δ inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells

2017 ◽  
Vol 28 (4) ◽  
pp. 436-445 ◽  
Author(s):  
Ava Safaroghli-Azar ◽  
Davood Bashash ◽  
Parisa Sadreazami ◽  
Majid Momeny ◽  
Seyed H. Ghaffari
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Apoptotic Effects

Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells

2012 ◽  
Vol 54 (3) ◽  
pp. 561-568 ◽  
Author(s):  
Davood Bashash ◽  
Seyed H. Ghaffari ◽  
Rooholah Mirzaee ◽  
Kamran Alimoghaddam ◽  
Ardeshir Ghavamzadeh
Keyword(s):  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Telomerase Inhibition

scholarly journals SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0134783 ◽  
Author(s):  
Jaíra Ferreira de Vasconcellos ◽  
Angelo Brunelli Albertoni Laranjeira ◽  
Paulo C. Leal ◽  
Manoj K. Bhasin ◽  
Priscila Pini Zenatti ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Acute Lymphoblastic Leukemia ◽  
Cell Cycle Arrest ◽  
Lymphoblastic Leukemia ◽  
Leukemia Cells ◽  
Cycle Arrest
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