Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib

Aline Houessinon; Albane Gicquel; Flora Bochereau; Christophe Louandre; Rémy Nyga; Corinne Godin; James Degonville; Emma Fournier; Zuzana Saidak; Claire Drullion; Jean-Claude Barbare; Bruno Chauffert; Catherine François; Olivier Pluquet; Antoine Galmiche

doi:10.1016/j.canlet.2015.10.032

Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib

Cancer Letters ◽

10.1016/j.canlet.2015.10.032 ◽

2016 ◽

Vol 370 (2) ◽

pp. 242-249 ◽

Cited By ~ 8

Author(s):

Aline Houessinon ◽

Albane Gicquel ◽

Flora Bochereau ◽

Christophe Louandre ◽

Rémy Nyga ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Carcinoma Cells ◽

Alpha Fetoprotein ◽

Hepatocellular Carcinoma Cells ◽

Unfolded Protein ◽

Protein Response

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Inhibition of histone demethylase KDM4 by ML324 induces apoptosis through the unfolded protein response and Bim upregulation in hepatocellular carcinoma cells

Chemico-Biological Interactions ◽

10.1016/j.cbi.2022.109806 ◽

2022 ◽

pp. 109806

Author(s):

So Young Kim ◽

Supyong Hwang ◽

Bo Ra Lee ◽

Jung A. Hong ◽

Young Hoon Sung ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Histone Demethylase ◽

Carcinoma Cells ◽

Hepatocellular Carcinoma Cells ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells

Oncotarget ◽

10.18632/oncotarget.23843 ◽

2018 ◽

Vol 9 (9) ◽

pp. 8400-8414 ◽

Cited By ~ 9

Author(s):

Chloé Sauzay ◽

Christophe Louandre ◽

Sandra Bodeau ◽

Frédéric Anglade ◽

Corinne Godin ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Protein Biosynthesis ◽

Carcinoma Cells ◽

Hepatocellular Carcinoma Cells ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.5b05668 ◽

2016 ◽

Vol 64 (8) ◽

pp. 1702-1711 ◽

Cited By ~ 12

Author(s):

Kai Zheng ◽

Chenghui Liao ◽

Yan Li ◽

Xinmin Fan ◽

Long Fan ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Reactive Oxygen Species ◽

Unfolded Protein Response ◽

Reactive Oxygen ◽

Carcinoma Cells ◽

Oxygen Species ◽

Hepatocellular Carcinoma Cells ◽

Cytoplasmic Vacuolation ◽

Unfolded Protein ◽

Protein Response

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Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT

Hepatology Research ◽

10.1111/hepr.12036 ◽

2013 ◽

Vol 43 (8) ◽

pp. 890-905 ◽

Cited By ~ 16

Author(s):

Min Xu ◽

Na Lu ◽

Haiwei Zhang ◽

Qinsheng Dai ◽

Libin Wei ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Carcinoma Cells ◽

Human Hepatocellular Carcinoma ◽

Hepatocellular Carcinoma Cells ◽

Unfolded Protein ◽

Protein Response ◽

Human Hepatocellular Carcinoma Cells

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Targeting the metabolic stress response in hepatocellular carcinoma through inhibition of the unfolded protein response

Journal of Vascular and Interventional Radiology ◽

10.1016/j.jvir.2015.12.073 ◽

2016 ◽

Vol 27 (3) ◽

pp. S23-S24

Author(s):

H. Nguyen ◽

M. Silk ◽

M. Nakazawa ◽

S. Hunt ◽

G. Nadolski ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Stress Response ◽

Unfolded Protein Response ◽

Metabolic Stress ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0b013e3283378405 ◽

2010 ◽

Vol 22 (9) ◽

pp. 1099-1105 ◽

Cited By ~ 45

Author(s):

Feras Y. Al-Rawashdeh ◽

Peter Scriven ◽

Ian C. Cameron ◽

Patricia V. Vergani ◽

Lynda Wyld

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Unfolded Protein ◽

Protein Response ◽

Response Activation

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MICA/B expression is inhibited by unfolded protein response and associated with poor prognosis in human hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research ◽

10.1186/s13046-014-0076-7 ◽

2014 ◽

Vol 33 (1) ◽

Cited By ~ 32

Author(s):

Liang Fang ◽

Jiuyu Gong ◽

Ying Wang ◽

Rongrong Liu ◽

Zengshan Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Poor Prognosis ◽

Human Hepatocellular Carcinoma ◽

Unfolded Protein ◽

Protein Response

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Publisher Correction: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

Cell Death and Disease ◽

10.1038/s41419-018-1292-4 ◽

2019 ◽

Vol 10 (3) ◽

Cited By ~ 2

Author(s):

Shanshan Wang ◽

Mingyue Zhu ◽

Qiaoyun Wang ◽

Yuli Hou ◽

Lei Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Carcinoma Cells ◽

Alpha Fetoprotein ◽

Hepatocellular Carcinoma Cells ◽

Mtor Signalling

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The Unfolded Protein Response Underlies Microenvironmental Stress-Induced Phenotype Switching Leading to Stemness and Chemoresistance in Human Hepatocellular Carcinoma

Journal of Hepatology ◽

10.1016/s0168-8278(16)01070-9 ◽

2016 ◽

Vol 64 (2) ◽

pp. S583

Author(s):

Y.-P. Vandewynckel ◽

O. Govaere ◽

A. Vandierendonck ◽

D. Laukens ◽

L. Devisscher ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Unfolded Protein Response ◽

Human Hepatocellular Carcinoma ◽

Unfolded Protein ◽

Microenvironmental Stress ◽

Phenotype Switching ◽

The Unfolded Protein Response ◽

Protein Response

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Targeting unfolded protein response sensitizes urothelial carcinoma cells to cisplatin chemotherapy

European Urology Supplements ◽

10.1016/s1569-9056(16)30468-7 ◽

2016 ◽

Vol 15 (13) ◽

pp. e1690

Author(s):

K.S. Han ◽

J.H. Heo ◽

S.E. Lee ◽

S.K. Hong ◽

...

Keyword(s):

Urothelial Carcinoma ◽

Unfolded Protein Response ◽

Carcinoma Cells ◽

Unfolded Protein ◽

Protein Response

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