scholarly journals Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

2015 ◽  
Vol 364 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Mark I. James ◽  
Chinenye Iwuji ◽  
Glen Irving ◽  
Ankur Karmokar ◽  
Jennifer A. Higgins ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Ex Vivo ◽  
Folfox Chemotherapy ◽  
Cell Phenotypes

scholarly journals Immunohistochemical Detection of Cancer Stem Cell Related Markers CD44 and CD133 in Metastatic Colorectal Cancer Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Pavel Pitule ◽  
Miroslava Cedikova ◽  
Ondrej Daum ◽  
Jan Vojtisek ◽  
Ondrej Vycital ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Staining Intensity ◽  
Disease Free Interval ◽  
Cd133 Expression ◽  
Free Interval ◽  
Disease Free

Aim. The goal of this study was to semiquantitatively detect presence of cancer stem cells markers CD44 and CD133 in immunohistochemically stained paired samples of colorectal cancer (CRC) and colorectal liver metastases (CLM). Level of staining intensity was compared to clinical and pathological characteristics of tumors with the aim to identify impact of CD44 or CD133 expression on tumor behavior.Patients and Methods. Formalin fixed paraffin embedded samples from 94 patients with colorectal tumor and liver metastases were collected at Sikl’s Department of Pathology. Samples were stained by antibodies against CD44 and CD133. Presence and intensity of staining was assessed semiquantitatively by three trained researchers.Results. Patients with higher level of CD133 staining in CRC had longer disease free interval (Cox-MantelP=0.0244), whereas we found no relation between CD44 expression and overall survival or disease free interval. CD133 expression in CRC and CLM differed based on CRC grading; in case of CD44 we found differences in staining intensity in individual stages of tumor lymph node invasion.Conclusion. Effect of cancer stem cell markers on prognosis of colorectal cancer can vary depending on pathological classification of tumor, and we have shown that CD133, generally considered to be a negative marker, can bear also clinically positive prognostic information in group of patients with colorectal liver metastases.

scholarly journals Forced expression of Nanog with mRNA synthesized in vitro to evaluate the malignancy of HeLa cells through acquiring cancer stem cell phenotypes

2016 ◽  
Vol 35 (5) ◽  
pp. 2643-2650 ◽  
Author(s):  
YAN DING ◽  
AI QING YU ◽  
XIAO LI WANG ◽  
XING RONG GUO ◽  
YA HONG YUAN ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Hela Cells ◽  
Cell Phenotypes

scholarly journals Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes

2018 ◽  
Vol 16 (4) ◽  
pp. 707-719 ◽  
Author(s):  
Thu H. Truong ◽  
Hsiangyu Hu ◽  
Nuri A. Temiz ◽  
Kyla M. Hagen ◽  
Brian J. Girard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Models ◽  
Cell Phenotypes

Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter

2009 ◽  
Vol 275 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Alexei V. Salnikov ◽  
Grace Kusumawidjaja ◽  
Vanessa Rausch ◽  
Helge Bruns ◽  
Wolfgang Gross ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Liver Metastases ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Prognostic Parameter ◽  
Marker Expression

2502 POSTER Microwave Ablation of Ex Vivo Human Liver and Colorectal Liver Metastases With a Novel 14.5 GHz Generator

2011 ◽  
Vol 47 ◽  
pp. S217-S218
Author(s):  
R. Jones ◽  
D. Dunne ◽  
M. Terlizzo ◽  
S. Fenwick ◽  
H. Malik ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Human Liver ◽  
Microwave Ablation ◽  
Colorectal Liver Metastases ◽  
Ex Vivo
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