Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

2013 ◽  
Vol 330 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Ning Yang ◽  
Ying Tang ◽  
Fang Wang ◽  
Haibin Zhang ◽  
Dan Xu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Hepatocarcinoma Cell ◽  
Focal Adhesion Turnover

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

2008 ◽  
Vol 68 (20) ◽  
pp. 8210-8220 ◽  
Author(s):  
Bharat Joshi ◽  
Scott S. Strugnell ◽  
Jacky G. Goetz ◽  
Liliana D. Kojic ◽  
Michael E. Cox ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Focal Adhesion ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Caveolin 1

scholarly journals Rab40/Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration and invasion

2021 ◽  
Author(s):  
Erik S Linklater ◽  
Emily Duncan ◽  
Ke Jun Han ◽  
Algirdas Kaupinis ◽  
Mindaugas Valius ◽  
...  
Keyword(s):  
Cell Migration ◽  
Actin Cytoskeleton ◽  
Focal Adhesion ◽  
Focal Adhesions ◽  
Leading Edge ◽  
Stress Fibers ◽  
Actin Dynamics ◽  
Migration And Invasion ◽  
Matrix Remodeling ◽  
Cell Migration And Invasion

Rab40b is a SOCS box containing protein that regulates the secretion of MMPs to facilitate extracellular matrix remodeling during cell migration. Here we show that Rab40b interacts with Cullin5 via the Rab40b SOCS domain. We demonstrate that loss of Rab40b/Cullin5 binding decreases cell motility and invasive potential, and show that defective cell migration and invasion stem from alteration to the actin cytoskeleton, leading to decreased invadopodia formation, decreased actin dynamics at the leading edge, and an increase in stress fibers. We also show that these stress fibers anchor at less dynamic, more stable focal adhesions. Mechanistically, changes in the cytoskeleton and focal adhesion dynamics are mediated in part by EPLIN, which we demonstrate to be a binding partner of Rab40b and a target for Rab40b/Cullin5 dependent localized ubiquitylation and degradation. Thus, we propose a model where the Rab40b/Cullin5 dependent ubiquitylation regulates EPLIN localization to promote cell migration and invasion by altering focal adhesion and cytoskeletal dynamics.

scholarly journals Extracellular HSP70/HSP70-PCs regulate hepatocarcinoma cell migration and invasion via RhoA

2016 ◽  
Vol 13 (3) ◽  
pp. 1095-1100 ◽  
Author(s):  
Zhe Yi ◽  
Yan Li ◽  
Dan Liu ◽  
Jingang Liu ◽  
Hangyu Li
Keyword(s):  
Cell Migration ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Hepatocarcinoma Cell

scholarly journals RITA modulates cell migration and invasion by affecting focal adhesion dynamics

2019 ◽  
Vol 13 (10) ◽  
pp. 2121-2141 ◽  
Author(s):  
Samira Catharina Hoock ◽  
Andreas Ritter ◽  
Kerstin Steinhäuser ◽  
Susanne Roth ◽  
Christian Behrends ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals SPAG9 is involved in hepatocarcinoma cell migration and invasion via modulation of ELK1 expression

2016 ◽  
pp. 1067 ◽  
Author(s):  
Qiuyue Yan ◽  
Guohua Lou ◽  
Ying Qian ◽  
Bo Qin ◽  
Xiuping Xu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Hepatocarcinoma Cell

MP23-08 MICRORNA-29S INHIBITS CANCER CELL MIGRATION AND INVASION VIA TARGETING FOCAL ADHESION PATHWAYS IN RENAL CELL CARCINOMA

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Hideki Enokida ◽  
Tomokazu Yonezawa ◽  
Takeshi Chiyomaru ◽  
Hirofumi Yoshino ◽  
Toshihiko Itesako ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Migration ◽  
Cell Carcinoma ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Renal Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion
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