Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation

2013 ◽  
Vol 328 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Shan Yu ◽  
Lin Jia ◽  
Yan Zhang ◽  
Dinglan Wu ◽  
Zhenyu Xu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nitric Oxide ◽  
Androgen Receptor ◽  
Nitric Oxide Synthase ◽  
Cancer Cells ◽  
Endothelial Nitric Oxide Synthase ◽  
Prostate Cancer Cells ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Receptor Transactivation

Endothelial Nitric Oxide Synthase Glu298Asp Polymorphism as a Risk Factor for Prostate Cancer

2013 ◽  
Vol 28 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Seyed Amir Mohsen Ziaei ◽  
Mohammad Samzadeh ◽  
Seyed Hamid Jamaldini ◽  
Mahdi Afshari ◽  
Ali Akbar Haghdoost ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Enos Gene ◽  
Inverse Association ◽  
Prostate Hyperplasia ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Glu298asp Polymorphism

Background The endothelial form of nitric oxide synthases (eNOS) seems to have an important role in vascular development, maintenance of the vascular tone and tumor growth in human prostate cancer (PC). The purpose of this study was to investigate the association between grade and stage of disease, age of diagnosis, vascular or perineural invasion, pre-diagnostic plasma prostate-specific antigen (PSA) levels, prostate cancer risk and Glu298Asp polymorphism of the eNOS gene. Methods Ninety-five prostate cancer patients and 111 benign prostate hyperplasia subjects were included. The Glu298Asp polymorphism of the eNOS gene was determined by polymerase chain reaction and restriction fragment length polymorphism Results The odds ratio (OR) between the GT and GG polymorphism was 0.76, indicating that the presence of the GT polymorphism decreased the risk of prostate cancer of more than 20% compared to the GG polymorphism. This difference, however, was not statistically significant. The GT polymorphism had an inverse association with cancer grade compared to the reference group (OR=0.47, p value=0.2). Conclusions These results suggest that prostate cancer development is not associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population. Further studies in larger samples are needed to confirm our results and characterize the molecular mechanisms by which eNOS is involved in the susceptibility to prostate cancer.

scholarly journals Genetic Variants within Endothelial Nitric Oxide Synthase Gene and Prostate Cancer: A Meta-Analysis

2014 ◽  
Vol 8 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Zorana Z. Nikolić ◽  
Dušanka Lj. Savić Pavićević ◽  
Stanka P. Romac ◽  
Goran N. Brajušković
Keyword(s):  
Prostate Cancer ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Genetic Variants ◽  
Endothelial Nitric Oxide Synthase ◽  
Meta Analysis ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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