Targeting a cornerstone of radiation resistance: Cancer stem cell

2012 ◽  
Vol 322 (2) ◽  
pp. 139-147 ◽  
Author(s):  
Coralie Moncharmont ◽  
Antonin Levy ◽  
Marion Gilormini ◽  
Gérald Bertrand ◽  
Cyrus Chargari ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Radiation Resistance

scholarly journals Exosomes Derived from Radioresistant Breast Cancer Cells Promote Therapeutic Resistance in Naïve Recipient Cells

2021 ◽  
Vol 11 (12) ◽  
pp. 1310
Author(s):  
Chantell Payton ◽  
Lisa Y. Pang ◽  
Mark Gray ◽  
David J. Argyle
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Cell Line ◽  
Radiation Resistance ◽  
Human Breast Cancer ◽  
Therapy Resistance ◽  
Biologically Active ◽  
Human Breast

Radiation resistance is a significant challenge in the treatment of breast cancer in humans. Human breast cancer is commonly treated with surgery and adjuvant chemotherapy/radiotherapy, but recurrence and metastasis upon the development of therapy resistance results in treatment failure. Exosomes are extracellular vesicles secreted by most cell types and contain biologically active cargo that, when transferred to recipient cells, can influence the cells’ genome and proteome. We propose that exosomes secreted by radioresistant (RR) cells may be able to disseminate the RR phenotype throughout the tumour. Here, we isolated exosomes from the human breast cancer cell line, MDA-MB-231, and the canine mammary carcinoma cell line, REM134, and their RR counterparts to investigate the effects of exosomes derived from RR cells on non-RR recipient cells. Canine mammary cancer cells lines have previously been shown to be excellent translational models of human breast cancer. This is consistent with our current data showing that exosomes derived from RR cells can increase cell viability and colony formation in naïve recipient cells and increase chemotherapy and radiotherapy resistance, in both species. These results are consistent in cancer stem cell and non-cancer stem cell populations. Significantly, exosomes derived from RR cells increased the tumoursphere-forming ability of recipient cells compared to exosomes derived from non-RR cells. Our results show that exosomes are potential mediators of radiation resistance that could be therapeutically targeted.

Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance

2011 ◽  
Vol 99 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Filippo P. D’Andrea ◽  
Akmal Safwat ◽  
Moustapha Kassem ◽  
Laurant Gautier ◽  
Jens Overgaard ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Radiation Resistance

scholarly journals Evaluation of Cancer Stem Cell Markers CD133, CD44, CD24: Association with AKT Isoforms and Radiation Resistance in Colon Cancer Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94621 ◽  
Author(s):  
Sara Häggblad Sahlberg ◽  
Diana Spiegelberg ◽  
Bengt Glimelius ◽  
Bo Stenerlöw ◽  
Marika Nestor
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Radiation Resistance ◽  
Stem Cell Markers ◽  
Colon Cancer Cells ◽  
Cell Markers ◽  
Cancer Stem Cell Markers ◽  
Akt Isoforms

Cancer Stem Cell: A Big Hurdle in Cancer Therapy

2015 ◽  
Vol 1 (1) ◽  
pp. 1 ◽  
Author(s):  
Nahid Arghiani ◽  
Maryam M. Matin
Keyword(s):  
Stem Cell ◽  
Cancer Therapy ◽  
Cancer Stem Cell
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