Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4

2012 ◽  
Vol 321 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Yongjie Zhang ◽  
Xia Zhang ◽  
Xi Wang ◽  
Lu Gan ◽  
Guanzhen Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Small Interfering Rna ◽  
Intestinal Type ◽  
Interfering Rna

scholarly journals Albendazole Exhibits Anti-Neoplastic Actions against Gastric Cancer Cells by Affecting STAT3 and STAT5 Activation by Pleiotropic Mechanism(s)

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 362
Author(s):  
Min Hee Yang ◽  
In Jin Ha ◽  
Jae-Young Um ◽  
Kwang Seok Ahn
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Small Interfering Rna ◽  
Oxygen Species ◽  
Gastric Cancer Cells ◽  
Drug Induced ◽  
Cellular Apoptosis ◽  
Interfering Rna

Albendazole (ABZ) has been reported to display anti-tumoral actions against various maliganncies, but possible impact of ABZ on gastric cancer has not been deciphered. As aberrant phosphorylation of STAT3 and STAT5 proteins can regulate the growth and progression of gastric cancer, we postulated that ABZ may interrupt the activation of these oncogenic transcription factors. We found that ABZ exposure abrogated STAT3/5 activation, inhibited phosphorylation of Janus-activated kinases 1/2 and Src and enhanced the levels of SHP-1 protein. Silencing of SHP-1 gene by small interfering RNA (siRNA) reversed the ABZ-promoted attenuation of STAT3 as well as STAT5 activation and cellular apoptosis. In addition, these effects were noted to be driven by an augmented levels of reactive oxygen species caused by drug-induced GSH/GSSG imbalance. Thus, the data indicates that ABZ can modulate the activation of STAT3 and STAT5 by pleiotropic mechanisms in gastric cancer cells.

scholarly journals Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells

2014 ◽  
Vol 13 (3) ◽  
pp. 6786-6803 ◽  
Author(s):  
Y.H. Li ◽  
M. Chen ◽  
M. Zhang ◽  
X.Q. Zhang ◽  
S. Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Small Interfering Rna ◽  
Inhibitory Effect ◽  
Gastric Cancer Cells ◽  
Interfering Rna

Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes

2019 ◽  
Vol 15 (3) ◽  
pp. 281-295 ◽  
Author(s):  
Feng Yang ◽  
Zhi Zheng ◽  
Xuchao Xue ◽  
Luming Zheng ◽  
Jianmin Qin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Small Interfering Rna ◽  
Gastric Cancer Stem Cells ◽  
Interfering Rna ◽  
Cd44 Targeting

Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cell

2010 ◽  
Vol 291 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Yan-Hong Zhang ◽  
Qing Wu ◽  
Xiu-Ying Xiao ◽  
Da-Wei Li ◽  
Xing-Peng Wang
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Small Interfering Rna ◽  
Gastric Cancer Cell ◽  
Interfering Rna

scholarly journals Interferon-αEnhances 5′-Deoxy-5-Fluorouridine-Induced Apoptosis by ERK-Dependant Upregulation of Thymidine Phosphorylase

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Yike Zhu ◽  
Ling Xu ◽  
Yibo Fan ◽  
Ce Li ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Small Interfering Rna ◽  
Thymidine Phosphorylase ◽  
Antitumor Efficacy ◽  
Erk Signaling ◽  
Gastric Cancer Cells ◽  
High Concentrations ◽  
Induced Apoptosis ◽  
Interfering Rna

5-Florouracil (5-FU) is the basic agent used in the treatment of gastric cancer. Capecitabine, a prodrug of 5-FU, displays increased antitumor efficacy compared with 5-FU in the clinic.5′-Deoxy-5-fluorouracil (5′-DFUR), the metabolite of capecitabine, is converted to 5-FU by the enzyme thymidine phosphorylase (TP), which is present at high concentrations in human tumors. In this study, we investigated the effect of interferon-α(IFN-α) on the sensitivity of gastric cancer cells to treatment with5′-DFUR and its relationship with TP expression. Preincubation of gastric cancer cells with IFN-αenhanced5′-DFUR-induced apoptosis via IFN-α-mediated upregulation of TP. The depletion of TP with small interfering RNA (siRNA) obviously inhibited IFN-α-induced upregulation of TP expression and thus prevented apoptosis induced by IFN-αand5′-DFUR. Treatment with IFN-αand combined IFN-αand5′-DFUR treatment were also associated with concomitant activation of ERK signaling. Treatment with the ERK inhibitor PD98059 or depletion of ERK with siRNA partially reversed IFN-α-induced upregulation of TP expression, thus partially preventing apoptosis induced by IFN-αand5′-DFUR. Taken together, our study shows that IFN-αenhanced5′-DFUR-induced apoptosis in gastric cancer cells by upregulation of TP expression, which is partially regulated by activation of ERK signaling.

scholarly journals A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer

2011 ◽  
Vol 14 (4) ◽  
pp. 339-352 ◽  
Author(s):  
Hui Chen ◽  
Lili Chen ◽  
Lingyu Sun ◽  
Hongqun Zhen ◽  
Xiaomei Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Therapy ◽  
Splice Variant ◽  
Small Interfering Rna ◽  
Rna Targeting ◽  
Interfering Rna
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