Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways

2012 ◽  
Vol 319 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Zhenbo Zhang ◽  
Dongmei Zhou ◽  
Yunli Lai ◽  
Yongjuan Liu ◽  
Xiang Tao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endometrial Cancer ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Fat Mass ◽  
Mapk Signaling ◽  
Cancer Cell Proliferation ◽  
Endometrial Cancer Cell ◽  
Proliferation And Invasion ◽  
Mapk Signaling Pathways

scholarly journals Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yun Luo ◽  
Jie-Ying Wu ◽  
Min-Hua Lu ◽  
Zhi Shi ◽  
Ning Na ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Mapk Signaling ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Du145 Cells ◽  
Mapk Signaling Pathways

TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization. Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well. Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways.

scholarly journals AMG 479, a Novel IGF-1-R Antibody, Inhibits Endometrial Cancer Cell Proliferation Through Disruption of the PI3K/Akt and MAPK Pathways

2011 ◽  
Vol 18 (9) ◽  
pp. 832-841 ◽  
Author(s):  
Albert Mendivil ◽  
Chunxiao Zhou ◽  
Leigh A. Cantrell ◽  
Paola A. Gehrig ◽  
Kim M. Malloy ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endometrial Cancer ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Endometrial Cancer Cell ◽  
Mapk Pathways

The effects of NT-1044, a novel AMPK activator, on endometrial cancer cell proliferation, apoptosis and cell stress

2015 ◽  
Vol 139 (3) ◽  
pp. 596
Author(s):  
Dario R. Roque ◽  
Weiya Z. Wysham ◽  
Chunxiao Zhou ◽  
Ken W. Batchelor ◽  
Victoria L. Bae-Jump
Keyword(s):  
Cell Proliferation ◽  
Endometrial Cancer ◽  
Cancer Cell ◽  
Cell Stress ◽  
Cancer Cell Proliferation ◽  
Endometrial Cancer Cell
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