Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt–mTOR signaling pathway in oral squamous cell carcinoma

2012 ◽  
Vol 319 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Vaishali Kapoor ◽  
Maya M. Zaharieva ◽  
Satya N. Das ◽  
Martin R. Berger
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma

2019 ◽  
Vol 31 (3) ◽  
Author(s):  
Amrita Devi Khwairakpam ◽  
Javadi Monisha ◽  
Nand Kishor Roy ◽  
Devivasha Bordoloi ◽  
Ganesan Padmavathi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Mtor Signaling ◽  
Dependent Manner ◽  
Mtor Signaling Pathway ◽  
Anticancer Properties

AbstractBackgroundAccording to GLOBOCAN 2018, oral cancer was reported as the second highest cancer prevalent in India. Despite the several therapies available for oral cancer treatment, tumor recurrence and distant metastasis persist. This study investigates the anticancer potential of Persicaria odorata, commonly known as Vietnamese coriander, used widely in traditional systems of medicine for the treatment of inflammation, stomach ailments, tumors, etc.MethodsThe crude methanolic extract of P. odorata (MPo) was prepared. The anticancer properties of MPo on SAS cells and other human oral squamous cell carcinoma cell line were evaluated using in vitro experimental conditions. The phytochemical constituents present in the MPo were also determined.ResultsPersicaria odorata possesses antiproliferative, antisurvival, antimetastatic activities, and induced cell cycle arrest in the G2 phase. It inhibited Akt-mammalian target of rapamycin (mTOR) signaling pathway and also downregulated the expression of essential proteins that are involved in tumorigenesis such as cyclin D1, cyclooxygenase 2 (COX2), survivin, matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor-A (VEGF-A). Moreover, the presence of flavonoids and quinones also revealed the anticancer activity of the plant.ConclusionOverall, our study concludes that P. odorata exhibits its anticancer properties through the downregulation of Akt/mTOR signaling pathway in a dose-dependent manner.

mTOR Signaling Pathway in Penile Squamous Cell Carcinoma: pmTOR and peIF4E Over Expression Correlate with Aggressive Tumor Behavior

2013 ◽  
Vol 190 (6) ◽  
pp. 2288-2295 ◽  
Author(s):  
Carla Ferrandiz-Pulido ◽  
Emili Masferrer ◽  
Agustin Toll ◽  
Javier Hernandez-Losa ◽  
Sergio Mojal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Over Expression ◽  
Aggressive Tumor ◽  
Penile Squamous Cell Carcinoma
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