scholarly journals Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells

2011 ◽  
Vol 313 (2) ◽  
pp. 201-210 ◽  
Author(s):  
Qi Zhang ◽  
Yan Ma ◽  
Yue-Fang Cheng ◽  
Wen-Jie Li ◽  
Zhenzhong Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuroblastoma Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Induced Apoptosis

scholarly journals 4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Amnah M. Alshangiti ◽  
Eszter Tuboly ◽  
Shane V. Hegarty ◽  
Cathal M. McCarthy ◽  
Aideen M. Sullivan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cytotoxic Effect ◽  
Neuroblastoma Cells ◽  
Reactive Oxygen ◽  
Prognostic Indicator ◽  
Oxygen Species ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma

Neuroblastoma is an embryonal malignancy that arises from cells of sympathoadrenal lineage during the development of the nervous system. It is the most common pediatric extracranial solid tumor and is responsible for 15% of childhood deaths from cancer. Fifty percent of cases are diagnosed as high-risk metastatic disease with a low overall 5-year survival rate. More than half of patients experience disease recurrence that can be refractory to treatment. Amplification of the MYCN gene is an important prognostic indicator that is associated with rapid disease progression and a poor prognosis, highlighting the need for new therapeutic approaches. In recent years, there has been an increasing focus on identifying anticancer properties of naturally occurring chalcones, which are secondary metabolites with variable phenolic structures. Here, we report that 4-hydroxychalcone is a potent cytotoxin for MYCN-amplified IMR-32 and SK-N-BE (2) neuroblastoma cells, when compared to non-MYCN-amplified SH-SY5Y neuroblastoma cells and to the non-neuroblastoma human embryonic kidney cell line, HEK293t. Moreover, 4-hydroxychalcone treatment significantly decreased cellular levels of the antioxidant glutathione and increased cellular reactive oxygen species. In addition, 4-hydroxychalcone treatment led to impairments in mitochondrial respiratory function, compared to controls. In support of this, the cytotoxic effect of 4-hydroxychalcone was prevented by co-treatment with either the antioxidant N-acetyl-L-cysteine, a pharmacological inhibitor of oxidative stress-induced cell death (IM-54) or the mitochondrial reactive oxygen species scavenger, Mito-TEMPO. When combined with the anticancer drugs cisplatin or doxorubicin, 4-hydroxychalcone led to greater reductions in cell viability than was induced by either anti-cancer agent alone. In summary, this study identifies a cytotoxic effect of 4-hydroxychalcone in MYCN-amplified human neuroblastoma cells, which rationalizes its further study in the development of new therapies for pediatric neuroblastoma.

scholarly journals Reactive Oxygen Species Regulate the Levels of Dual Oxidase (Duox1-2) in Human Neuroblastoma Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34405 ◽  
Author(s):  
Simona Damiano ◽  
Roberta Fusco ◽  
Annalisa Morano ◽  
Mariarosaria De Mizio ◽  
Roberto Paternò ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuroblastoma Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Dual Oxidase

Cholinergic-induced production of reactive oxygen species in human neuroblastoma cells

Life Sciences ◽  
1997 ◽  
Vol 60 (21) ◽  
pp. 1905-1914 ◽  
Author(s):  
Jonne Naarala ◽  
Pirkko Tervo ◽  
Jarkko Loikkanen ◽  
Kai Savolainen
Keyword(s):  
Reactive Oxygen Species ◽  
Neuroblastoma Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma

scholarly journals Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells

2012 ◽  
Vol 27 (4) ◽  
pp. 1233-1237 ◽  
Author(s):  
YA-HUI CHEN ◽  
CHI-WEI YEH ◽  
HUI-CHEN LO ◽  
SHIH-LI SU ◽  
YOU-CHENG HSEU ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuroblastoma Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Induced Apoptosis
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