Retinoic acid receptor β2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells

2007 ◽  
Vol 247 (2) ◽  
pp. 318-327 ◽  
Author(s):  
Zhongming Zhang ◽  
Keiichiro Joh ◽  
Hitomi Yatsuki ◽  
Wei Zhao ◽  
Hidenobu Soejima ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Histone Modifications ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Cervical Cancer Cells ◽  
Retinoic Acid Receptor Β2

Discovery of Novel Retinoic Acid Receptor Agonists Having Potent Antiproliferative Activity in Cervical Cancer Cells

1996 ◽  
Vol 39 (14) ◽  
pp. 2659-2663 ◽  
Author(s):  
Lin Zhang ◽  
Alex M. Nadzan ◽  
Richard A. Heyman ◽  
Deborah L. Love ◽  
Dale E. Mais ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Receptor Agonists ◽  
Cervical Cancer Cells

scholarly journals Methylation and silencing of the retinoic acid receptor-β2 gene in cervical cancer

BMC Cancer ◽  
2002 ◽  
Vol 2 (1) ◽  
Author(s):  
Tatyana Ivanova ◽  
Anatolii Petrenko ◽  
Tatyana Gritsko ◽  
Svetlana Vinokourova ◽  
Ernest Eshilev ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Β2

scholarly journals Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells

Oncogene ◽  
2000 ◽  
Vol 19 (12) ◽  
pp. 1556-1563 ◽  
Author(s):  
Silvia M Sirchia ◽  
Anne T Ferguson ◽  
Elena Sironi ◽  
Smitha Subramanyan ◽  
Rosaria Orlandi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Chromatin State ◽  
Epigenetic Changes ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Β2

scholarly journals Epigenetic patterns of the retinoic acid receptor β2 promoter in retinoic acid-resistant thyroid cancer cells

Oncogene ◽  
2007 ◽  
Vol 26 (27) ◽  
pp. 4018-4024 ◽  
Author(s):  
A Cras ◽  
D Darsin-Bettinger ◽  
N Balitrand ◽  
B Cassinat ◽  
A Soulié ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Β2 ◽  
Epigenetic Patterns ◽  
Thyroid Cancer Cells

Retinoic acid receptor α1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells

1995 ◽  
Vol 109 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Bas-jan M. van der Leede ◽  
Gert E. Folkers ◽  
Christina E. van den Brink ◽  
Paul T. van der Saag ◽  
Bart van der Burg
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Acid Sensitivity ◽  
Acid Receptor

scholarly journals Orphan Receptor COUP-TF Is Required for Induction of Retinoic Acid Receptor β, Growth Inhibition, and Apoptosis by Retinoic Acid in Cancer Cells

2000 ◽  
Vol 20 (3) ◽  
pp. 957-970 ◽  
Author(s):  
Bingzhen Lin ◽  
Guo-quan Chen ◽  
Dongmei Xiao ◽  
Siva Kumar Kolluri ◽  
Xihua Cao ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Retinoic Acid Receptor ◽  
Critical Role ◽  
Orphan Receptor ◽  
Dependent Manner ◽  
Anticancer Activities ◽  
Transient Transfection Assay ◽  
Acid Receptor

ABSTRACT Retinoic acid receptor β (RARβ) plays a critical role in mediating the anticancer effects of retinoids. Expression of RARβ is highly induced by retinoic acid (RA) through a RA response element (βRARE) that is activated by heterodimers of RARs and retinoid X receptors (RXRs). However, RARβ induction is often lost in cancer cells despite expression of RARs and RXRs. In this study, we provide evidence that orphan receptor COUP-TF is required for induction of RARβ expression, growth inhibition, and apoptosis by RA in cancer cells. Expression of COUP-TF correlates with RARβ induction in a variety of cancer cell lines. In addition, stable expression of COUP-TF in COUP-TF-negative cancer cells restores induction of RARβ expression, growth inhibition, and apoptosis by RA, whereas inhibition of COUP-TF by expression of COUP-TF antisense RNA represses the RA effects. In a transient transfection assay, COUP-TF strongly induced transcriptional activity of the RARβ promoter in a RA- and RARα-dependent manner. By mutation analysis, we demonstrate that the effect of COUP-TF requires its binding to a DR-8 element present in the RARβ promoter. The binding of COUP-TF to the DR-8 element synergistically increases the RA-dependent RARα transactivation function by enhancing the interaction of RARα with its coactivator CREB binding protein. These results demonstrate that COUP-TF, by serving as an accessory protein for RARα to induce RARβ expression, plays a critical role in regulating the anticancer activities of retinoids.

Ligand-inducible retinoid X receptor-mediated protein: DNA interactions in the retinoic acid receptor β2 gene promoter in vivo

1998 ◽  
Vol 136 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Masato Ikeda ◽  
Remco A Spanjaard ◽  
Elizabeth W Noordhoek ◽  
Akio Kawaguchi ◽  
Toshimasa Onaya ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Gene Promoter ◽  
Retinoid X Receptor ◽  
Dna Interactions ◽  
Acid Receptor ◽  
Protein Dna Interactions ◽  
Retinoic Acid Receptor Β2
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