Human tissue kallikrein gene family: applications in cancer

2005 ◽  
Vol 224 (1) ◽  
pp. 1-22 ◽  
Author(s):  
Christina V. Obiezu ◽  
Eleftherios P. Diamandis
Keyword(s):  
Gene Family ◽  
Human Tissue ◽  
Tissue Kallikrein

scholarly journals New Nomenclature for the Human Tissue Kallikrein Gene Family

2000 ◽  
Vol 46 (11) ◽  
pp. 1855-1858 ◽  
Author(s):  
Eleftherios P Diamandis ◽  
George M Yousef ◽  
Judith Clements ◽  
Linda K Ashworth ◽  
Shigetaka Yoshida ◽  
...  
Keyword(s):  
Gene Family ◽  
Human Tissue ◽  
Tissue Kallikrein

Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer

2009 ◽  
Vol 101 (04) ◽  
pp. 741-747 ◽  
Author(s):  
Konstantina Mathioudaki ◽  
Panagiotis Prezas ◽  
Dimitra Alexopoulou ◽  
Eleftherios Diamandis ◽  
Dimitris Xynopoulos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Stratum Corneum ◽  
Human Tissue ◽  
Serine Proteases ◽  
Human Cancer ◽  
Disease Free Survival ◽  
Normal Colonic Mucosa ◽  
Tissue Kallikrein ◽  
Human Cancer Cell Lines

SummaryHuman tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 (KLK7) has been purified from human stratum corneum and resembles a chymotryptic endopeptidase originally called stratum corneum chymotryptic enzyme (SCCE). In this study, we examined for the first time, the prognostic value of KLK7 mRNA expression, using a semi-quantitative RT-PCR method, in 105 colorectal cancer tissues for 54 of which, paired normal colonic mucosa were available. Furthermore, we analysed the expression of KLK7 in 10 adenomas, in 18 biopsies of inflamed colon mucosa, as well as in 22 human cancer cell lines of various origin, four of them being of colon. A defined number of colon cancer samples were also examined by immunohisto-chemistry. KLK7 expression was higher in cancerous than in normal tissues. Less differentiated tumors of more advanced stage showed higher KLK7 expression. Follow-up analysis revealed that KLK7 was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). In addition, selected colon cancer samples highly expressing KLK7 gene, showed intense immunohistochemical staining for KLK7, enhancing RTPCR results. Present data suggest that KLK7 gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients.

Human Tissue Kallikrein: A New Bullet for the Treatment of Ischemia

2003 ◽  
Vol 9 (7) ◽  
pp. 589-597 ◽  
Author(s):  
Costanza Emanueli ◽  
Paolo Madeddu
Keyword(s):  
Human Tissue ◽  
Tissue Kallikrein

scholarly journals Specificity of human tissue kallikrein towards substrates containing Phe‒Phe pair of amino acids

1999 ◽  
Vol 339 (2) ◽  
pp. 473 ◽  
Author(s):  
Daniel C. PIMENTA ◽  
Julie CHAO ◽  
Lee CHAO ◽  
Maria A. JULIANO ◽  
Luiz JULIANO
Keyword(s):  
Amino Acids ◽  
Human Tissue ◽  
Tissue Kallikrein
Sign in / Sign up

Export Citation Format

Share Document