The importance of an exponential prostate-specific antigen decline after external beam radiotherapy for intermediate risk prostate cancer

2012 ◽  
Vol 36 (2) ◽  
pp. e137-e141 ◽  
Author(s):  
Guila Delouya ◽  
Gabriel Kaufman ◽  
Marie-Pierre Sylvestre ◽  
Thu-Van Nguyen ◽  
Jean-Paul Bahary ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
External Beam Radiotherapy ◽  
Specific Antigen ◽  
External Beam ◽  
Intermediate Risk ◽  
Risk Prostate Cancer

A comparison of overall and cause-specific survival among patients with low- and intermediate-risk prostate cancer treated with brachytherapy, external beam radiotherapy, or radical prostatectomy

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 5126-5126 ◽  
Author(s):  
J. P. Ciezki ◽  
C. A. Reddy ◽  
P. A. Kupelian ◽  
E. A. Klein ◽  
C. Robinson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
External Beam Radiotherapy ◽  
Smoking History ◽  
External Beam ◽  
Intermediate Risk ◽  
Charlson Score ◽  
Risk Of Death ◽  
Risk Prostate Cancer ◽  
Cause Specific Survival

5126 Background: The factors thought to influence overall survival (OS) and cause-specific survival (CSS) in patients treated for low and intermediate-risk prostate cancer (CaP) with brachytherapy (PI), external beam radiotherapy (RT), or radical prostatectomy (RP) were evaluated. Methods: From 1996 to 2003, 2285 patients with low or intermediate-risk CaP were treated at the Cleveland Clinic with either PI (n=662), RT (n=570), or RP (n=1053). Factors thought to influence OS and CSS were recorded. These factors included: Charlson score, age, socioeconomic status, race, body mass index (BMI), presence of coronary artery disease (CAD), presence of hypertension (HTN), presence of dyslipidemia (DL), initial prostate-specific antigen (iPSA), biopsy Gleason score (bGS), clinical stage, use of androgen deprivation (AD), AD duration, smoking history including pack-years, alcohol use, and cancer treatment modality (TX). Univariate and multivariate analyses were done using Cox proportional hazards regression. Results: The median follow-up is 59 months (range: 24–119 months). The 5- year OS rate is 96.0%, and the 8-year rate is 89.9%. Multivariate analysis revealed that Charlson score, age, smoking history, and TX were significantly associated with OS. Treatment with RT was independently associated with worse OS relative to PI and RP. CSS was grouped into 4 major categories: CAD, CaP, other cancer, and other. The only significant difference between these CSS categories and the treatment modalities was CaP. The percent of deaths due to CaP in the TX groups were: PI - 3.2%, RP - 9.7%, and RT - 24.5%. Conclusions: Charlson score, age, smoking history, and TX independently affect OS in patients treated for low and intermediate-risk CaP. The cause of the lower OS rate with RT may be related to an increased risk of death due to CaP. [Table: see text] No significant financial relationships to disclose.

Sign in / Sign up

Export Citation Format

Share Document