Key roles of LFA-1 in leukocyte migration and immune response

2006 ◽  
Vol 6 (3-4) ◽  
pp. 191-200
Author(s):  
L. Zecchinon ◽  
T. Fett ◽  
P. Vanden Bergh ◽  
D. Desmecht
Keyword(s):  
Immune Response ◽  
Leukocyte Migration

Impaired Cell-Mediated Immune Response in Patients with Congenital Rubella: Correlation with Gestational Age at Time of Infection

PEDIATRICS ◽  
1979 ◽  
Vol 64 (5) ◽  
pp. 620-626
Author(s):  
Elena Buimovici-Klein ◽  
Paul B. Lang ◽  
Philip R. Ziring ◽  
Louis Z. Cooper
Keyword(s):  
Immune Response ◽  
Gestational Age ◽  
Rubella Virus ◽  
Lymphocyte Transformation ◽  
Leukocyte Migration ◽  
Migration Inhibition Factor ◽  
Migration Inhibition ◽  
Inhibition Factor ◽  
Congenital Rubella ◽  
Leukocyte Migration Inhibition

Lymphocyte transformation, interferon, and leukocyte migration inhibition factor synthesis were studied in purified lymphocyte cultures for 20 children with congenital rubella and 18 healthy children (seven susceptible and 11 immune to rubella). Lymphocyte transformation after phytohemagglutinin stimulation was significantly lower in children with congenital rubella as compared to healthy controls. Responses to purified rubella virus were absent in the susceptible controls and absent or at least two times lower in congenital rubella children than in immune controls. After purified rubella virus stimulation, leukocyte migration inhibition factor production was detected in all immune controls, but in none of the susceptible controls, or the congenital rubella-infected children. The results varied with gestational age of intrauterine infection: the impairment of cellular immune response, both after phytohemagglutinin or rubella virus stimulation, was more severe in the children infected in the first two months than in the latter stages of gestation.

scholarly journals β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration

2021 ◽  
Vol 12 ◽  
Author(s):  
Eoin N. Blythe ◽  
Lynne C. Weaver ◽  
Arthur Brown ◽  
Gregory A. Dekaban
Keyword(s):  
Immune Response ◽  
Transcriptional Control ◽  
Therapeutic Agents ◽  
Leukocyte Migration ◽  
Signalling Pathways ◽  
Adhesive Properties ◽  
Β2 Integrin ◽  
Peripheral Leukocytes ◽  
Key Aspects

CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation. Differential expression of CD11d induces differences in monocyte/macrophage mesenchymal migration including impacts on macrophage sub-set migration. The participation of CD11d/CD18 in leukocyte localization during atherosclerosis and following neurotrauma has sparked interest in the development of CD11d-targeted therapeutic agents. Whereas the adhesive properties of CD11d have undergone investigation, the signalling pathways induced by ligand binding remain largely undefined. Underlining each adhesive and signalling function, CD11d is under unique transcriptional control and expressed on a sub-set of predominately tissue-differentiated innate leukocytes. The following review is the first to capture the nearly three decades of CD11d research and discusses the emerging role of CD11d in leukocyte migration and retention during the progression of a staged immune response.

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune

Abstract #418: Effect of Testosterone (T) Replacement with a T-Gel or a New Oral T Formulation (Rextoro) on Selected Biomarkers of Endothelial Injury and Immune Response to Lipids

2015 ◽  
Vol 21 ◽  
pp. 93
Author(s):  
Merrell Magelli ◽  
Ronald Swerdloff ◽  
John Amory ◽  
Gregory Flippo ◽  
Wael Salameh ◽  
...  
Keyword(s):  
Immune Response ◽  
Endothelial Injury

Author response for "Diabetes alters immune response patterns to acute melioidosis in humans"

2019 ◽  
Author(s):  
Barbara Kronsteiner ◽  
Panjaporn Chaichana ◽  
Manutsanun Sumonwiriya ◽  
Kemajitra Jenjaroen ◽  
Fazle Rabbi Chowdhury ◽  
...  
Keyword(s):  
Immune Response ◽  
Author Response ◽  
Response Patterns
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