Visualizing MR diffusion tensor fields by dynamic fiber tracking and uncertainty mapping

2006 ◽  
Vol 30 (2) ◽  
pp. 255-264 ◽  
Author(s):  
Hans-H. Ehricke ◽  
Uwe Klose ◽  
Wolfgang Grodd
Keyword(s):  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Tensor Fields ◽  
Mr Diffusion ◽  
Uncertainty Mapping

MR diffusion tensor imaging and fiber tracking in spinal cord lesions

2013 ◽  
Vol 333 ◽  
pp. e553
Author(s):  
S. Leis ◽  
M. Seidl ◽  
L. Grassner ◽  
M. Mc Coy ◽  
E. Trinka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Spinal Cord Lesions ◽  
Mr Diffusion ◽  
Mr Diffusion Tensor Imaging

Accuracy of diffusion tensor magnetic resonance imaging tractography assessed using intraoperative subcortical stimulation mapping and magnetic source imaging

2007 ◽  
Vol 107 (3) ◽  
pp. 488-494 ◽  
Author(s):  
Jeffrey I. Berman ◽  
Mitchel S. Berger ◽  
Sungwon Chung ◽  
Srikantan S. Nagarajan ◽  
Roland G. Henry
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Bipolar Electrode ◽  
Source Imaging ◽  
Magnetic Source Imaging ◽  
Motor Pathway ◽  
Magnetic Source ◽  
Subcortical Stimulation

Object Resecting brain tumors involves the risk of damaging the descending motor pathway. Diffusion tensor (DT)–imaged fiber tracking is a noninvasive magnetic resonance (MR) technique that can delineate the subcortical course of the motor pathway. The goal of this study was to use intraoperative subcortical stimulation mapping of the motor tract and magnetic source imaging to validate the utility of DT-imaged fiber tracking as a tool for presurgical planning. Methods Diffusion tensor-imaged fiber tracks of the motor tract were generated preoperatively in nine patients with gliomas. A mask of the resultant fiber tracks was overlaid on high-resolution T1- and T2-weighted anatomical MR images and used for stereotactic surgical navigation. Magnetic source imaging was performed in seven of the patients to identify functional somatosensory cortices. During resection, subcortical stimulation mapping of the motor pathway was performed within the white matter using a bipolar electrode. Results A total of 16 subcortical motor stimulations were stereotactically identified in nine patients. The mean distance between the stimulation sites and the DT-imaged fiber tracks was 8.7 ±3.1 mm (±standard deviation). The measured distance between subcortical stimulation sites and DT-imaged fiber tracks combines tracking technique errors and all errors encountered with stereotactic navigation. Conclusions Fiber tracks delineated using DT imaging can be used to identify the motor tract in deep white matter and define a safety margin around the tract.

Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging

2007 ◽  
Vol 293 (4) ◽  
pp. H2377-H2384 ◽  
Author(s):  
Yi Jiang ◽  
Julius M. Guccione ◽  
Mark B. Ratcliffe ◽  
Edward W. Hsu
Keyword(s):  
Diffusion Tensor Imaging ◽  
Volume Fraction ◽  
Diffusion Tensor ◽  
Extracellular Volume ◽  
Extracellular Volume Fraction ◽  
Left Ventricular ◽  
Fiber Direction ◽  
Significant Difference ◽  
Mr Diffusion ◽  
Mr Diffusion Tensor Imaging

The orientation of MRI-measured diffusion tensor in the myocardium has been directly correlated to the tissue fiber direction and widely characterized. However, the scalar anisotropy indexes have mostly been assumed to be uniform throughout the myocardial wall. The present study examines the fractional anisotropy (FA) as a function of transmural depth and circumferential and longitudinal locations in the normal sheep cardiac left ventricle. Results indicate that FA remains relatively constant from the epicardium to the midwall and then decreases (25.7%) steadily toward the endocardium. The decrease of FA corresponds to 7.9% and 12.9% increases in the secondary and tertiary diffusion tensor diffusivities, respectively. The transmural location of the FA transition coincides with the location where myocardial fibers run exactly circumferentially. There is also a significant difference in the midwall-endocardium FA slope between the septum and the posterior or lateral left ventricular free wall. These findings are consistent with the cellular microstructure from histological studies of the myocardium and suggest a role for MR diffusion tensor imaging in characterization of not only fiber orientation but, also, other tissue parameters, such as the extracellular volume fraction.

scholarly journals Thalamic Connectivity in Patients with Essential Tremor Treated with MR Imaging–guided Focused Ultrasound: In Vivo Fiber Tracking by Using Diffusion-Tensor MR Imaging

Radiology ◽  
2014 ◽  
Vol 272 (1) ◽  
pp. 202-209 ◽  
Author(s):  
Max Wintermark ◽  
Diane S. Huss ◽  
Binit B. Shah ◽  
Nicholas Tustison ◽  
T. Jason Druzgal ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Essential Tremor ◽  
Focused Ultrasound ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Diffusion Tensor Mr Imaging

Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas

Neurosurgery ◽  
2021 ◽  
Author(s):  
Fraser Henderson Jr ◽  
Drew Parker ◽  
Anupa A Vijayakumari ◽  
Mark Elliott ◽  
Timothy Lucas ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Free Water ◽  
High Grade Glioma ◽  
Fiber Tracking ◽  
High Grade ◽  
Peritumoral Edema ◽  
Fiber Tractography ◽  
Motor Pathways

Abstract BACKGROUND A limitation of diffusion tensor imaging (DTI)-based tractography is peritumoral edema that confounds traditional diffusion-based magnetic resonance metrics. OBJECTIVE To augment fiber-tracking through peritumoral regions by performing novel edema correction on clinically feasible DTI acquisitions and assess the accuracy of the fiber-tracks using intraoperative stimulation mapping (ISM), task-based functional magnetic resonance imaging (fMRI) activation maps, and postoperative follow-up as reference standards. METHODS Edema correction, using our bi-compartment free water modeling algorithm (FERNET), was performed on clinically acquired DTI data from a cohort of 10 patients presenting with suspected high-grade glioma and peritumoral edema in proximity to and/or infiltrating language or motor pathways. Deterministic fiber-tracking was then performed on the corrected and uncorrected DTI to identify tracts pertaining to the eloquent region involved (language or motor). Tracking results were compared visually and quantitatively using mean fiber count, voxel count, and mean fiber length. The tracts through the edematous region were verified based on overlay with the corresponding motor or language task-based fMRI activation maps and intraoperative ISM points, as well as at time points after surgery when peritumoral edema had subsided. RESULTS Volume and number of fibers increased with application of edema correction; concordantly, mean fractional anisotropy decreased. Overlay with functional activation maps and ISM-verified eloquence of the increased fibers. Comparison with postsurgical follow-up scans with lower edema further confirmed the accuracy of the tracts. CONCLUSION This method of edema correction can be applied to standard clinical DTI to improve visualization of motor and language tracts in patients with glioma-associated peritumoral edema.

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