Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine

2020 ◽  
Vol 1749 ◽  
pp. 147145
Author(s):  
Fernanda Silva Rodrigues ◽  
Angela Patrícia França ◽  
Núbia Broetto ◽  
Ana Flávia Furian ◽  
Mauro Schneider Oliveira ◽  
...  
Keyword(s):  
Glutaric Acid ◽  
Phases Of Development ◽  
Glial Reactivity

Characterization of Chemical Impurities in Glutaraldehyde

1975 ◽  
Vol 33 ◽  
pp. 620-621
Author(s):  
B. J. Grenon ◽  
A. J. Tousimis
Keyword(s):  
Glutaric Acid ◽  
Spectroscopic Analysis ◽  
Aldol Condensation ◽  
Condensation Product ◽  
Amorphous Solid ◽  
Water Soluble ◽  
Impurity Component ◽  
Chemical Impurities ◽  
Soluble Liquid

Ever since the introduction of glutaraldehyde as a fixative in electron microscopy of biological specimens, the identification of impurities and consequently their effects on biologic ultrastructure have been under investigation. Several reports postulate that the impurities of glutaraldehyde, used as a fixative, are glutaric acid, glutaraldehyde polymer, acrolein and glutaraldoxime.Analysis of commercially available biological or technical grade glutaraldehyde revealed two major impurity components, none of which has been reported. The first compound is a colorless, water-soluble liquid with a boiling point of 42°C at 16 mm. Utilizing Nuclear Magnetic Resonance (NMR) spectroscopic analysis, this compound has been identified to be — dihydro-2-ethoxy 2H-pyran. This impurity component of the glutaraldehyde biological or technical grades has an UV absorption peak at 235nm. The second compound is a white amorphous solid which is insoluble in water and has a melting point of 80-82°C. Initial chemical analysis indicates that this compound is an aldol condensation product(s) of glutaraldehyde.

Political Islam in an Ethnic Jewish State: Historical Evolution, Contemporary Challenges and Future Prospects

2004 ◽  
Vol 3 (1) ◽  
pp. 69-92 ◽  
Author(s):  
Nohad ‘Ali
Keyword(s):  
Historical Evolution ◽  
Jewish State ◽  
Islamic Revival ◽  
Islamic Movement ◽  
Revival Movements ◽  
Phases Of Development ◽  
Two Phases ◽  
The One ◽  
Five Phases ◽  
Islamic Revivalism

This paper argues that, although the shared and universal ideology of the Islamic revival movements was adopted by the Islamic movement in Israel, the movement has been trying to embody it in diverse and distinctive ways. In principle there is a conflict between commitment to the principle of Islamic revivalism on the one hand, and being so committed in the specific context of the ethnic Jewish state, on the other. The Jewish context of the State of Israel continues to bedevil the development of the Islamic movement in Israel. Since the 1930s, Islamic revivalism in Palestine has undergone five phases of development: the Egyptian, Israeli, Palestinian, and the two phases of ‘adaptation’ and ‘post-adaptation’. These phases reflect ideological developments, rather than simply a historical evolution. They are also the outcome of three sets of constraints: structural, ideological and domestic.

Introduction

2018 ◽  
Author(s):  
Michael P. DeJonge
Keyword(s):  
Political Life ◽  
Political Resistance ◽  
Clear Sense ◽  
Phases Of Development ◽  
Three Phases

The Introduction begins by noting the frequency and ease with which Bonhoeffer is mentioned in contemporary conversations about political resistance. Nonetheless, it would be difficult to derive from these appeals to Bonhoeffer any clear sense of the legacy of his political resistance. This raises the question: What did Bonhoeffer actually say about political resistance? Noting that Bonhoeffer spoke about political life primarily as a Christian pastor and Lutheran theologian, the Introduction sets forth the task of the book, which is a presentation of Bonhoeffer’s resistance thinking in the broader context of his theology. As summarized in the Introduction, this book presents Bonhoeffer’s resistance thinking chronologically according to three phases of development and systematically according to a sixfold typology of resistance.

The role of nitric oxide in glutaric acid‐induced convulsive behavior in pup rats

2020 ◽  
Vol 52 (7) ◽  
pp. 3738-3745
Author(s):  
César Augusto Brüning ◽  
Suzan Gonçalves Rosa ◽  
Caroline Brandão Quines ◽  
Danieli Valnes Magni ◽  
Natália Tavares Nonemacher ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glutaric Acid

scholarly journals Catalogue of hazards: a fundamental part for the safe design of surgical robots

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Lukas Theisgen ◽  
Florian Strauch ◽  
Matías de la Fuente ◽  
Klaus Radermacher
Keyword(s):  
Development Process ◽  
New Technologies ◽  
State Of The Art ◽  
Hazard Identification ◽  
Surgical Robots ◽  
Safety Measures ◽  
Fundamental Part ◽  
Phases Of Development ◽  
Early Phases ◽  
Intended Use

AbstractRisk classes defined by MDR and FDA for state-of-the-art surgical robots based on their intended use are not suitable as indicators for their hazard potential. While there is a lack of safety regulation for an increasing degree of automation as well as the degree of invasiveness into the patient’s body, adverse events have increased in the last decade. Thus, an outright identification of hazards as part of the risk analysis over the complete development process and life cycle of a surgical robot is crucial, especially when introducing new technologies. For this reason, we present a comprehensive approach for hazard identification in early phases of development. With this multi-perspective approach, the number of hazards identified can be increased. Furthermore, a generic catalogue of hazards for surgical robots has been established by categorising the results. The catalogue serves as a data pool for risk analyses and holds the potential to reduce hazards through safety measures already in the design process before becoming risks for the patient.

scholarly journals Synthesis, Properties, and Biodegradability of Thermoplastic Elastomers Made from 2-Methyl-1,3-propanediol, Glutaric Acid and Lactide

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 43
Author(s):  
Lamya Zahir ◽  
Takumitsu Kida ◽  
Ryo Tanaka ◽  
Yuushou Nakayama ◽  
Takeshi Shiono ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Glutaric Acid ◽  
Triblock Copolymers ◽  
Tensile Tests ◽  
Thermoplastic Elastomers ◽  
Proteinase K ◽  
Synthesis Properties

An innovative type of biodegradable thermoplastic elastomers with improved mechanical properties from very common and potentially renewable sources, poly(L-lactide)-b-poly(2-methyl-1,3-propylene glutarate)-b-poly(L-lactide) (PLA-b-PMPG-b-PLA)s, has been developed for the first time. PLA-b-PMPG-b-PLAs were synthesized by polycondensation of 2-methyl-1,3-propanediol and glutaric acid and successive ring-opening polymerization of L-lactide, where PMPG is an amorphous central block with low glass transition temperature and PLA is hard semicrystalline terminal blocks. The copolymers showed glass transition temperature at lower than −40 °C and melting temperature at 130–152 °C. The tensile tests of these copolymers were also performed to evaluate their mechanical properties. The degradation of the copolymers and PMPG by enzymes proteinase K and lipase PS were investigated. Microbial biodegradation in seawater was also performed at 27 °C. The triblock copolymers and PMPG homopolymer were found to show 9–15% biodegradation within 28 days, representing their relatively high biodegradability in seawater. The macromolecular structure of the triblock copolymers of PLA and PMPG can be controlled to tune their mechanical and biodegradation properties, demonstrating their potential use in various applications.

scholarly journals Increased canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase in dogs with evidence of portal hypertension and normal pancreatic histology: a pilot study

2021 ◽  
pp. 104063872110039
Author(s):  
Gonçalo Serrano ◽  
Dominique Paepe ◽  
Tim Williams ◽  
Penny Watson
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Pilot Study ◽  
Pancreatic Lipase ◽  
Glutaric Acid ◽  
Inclusion Criteria ◽  
Reference Limit ◽  
Clinical Presentations ◽  
Upper Reference Limit

The clinical presentations of both liver disease and pancreatitis are nonspecific and overlapping, which may cause difficulty in diagnosis. In our retrospective pilot study, we assessed whether dogs with evidence of portal hypertension and absence of pancreatitis on pancreatic histology have increases in canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase. We included dogs that had been presented between 2008 and 2019 if they had normal pancreatic histology, histologically confirmed hepatopathy, and if canine pancreas-specific lipase (Spec cPL; Idexx) or DGGR lipase had been measured. Only dogs with portal hypertension were included. Six dogs fulfilled the inclusion criteria. Four of 6 and 2 of 6 dogs had Spec cPL and DGGR lipase exceeding the upper reference limit, respectively. From the 4 dogs with increased Spec cPL, 2 had concentrations of 200–400 µg/L and 2 had concentrations ≥ 400 µg/L. Our results suggest that canine portal hypertension might lead to increased Spec cPL and DGGR lipase values in the absence of pancreatitis on histology. Until more evidence in a larger number of dogs with portal hypertension is available, both tests should be interpreted cautiously in the presence of portal hypertension.

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