Olfactory ensheathing glia cell therapy and tubular conduit enhance nerve regeneration after mouse sciatic nerve transection

2016 ◽  
Vol 1650 ◽  
pp. 243-251 ◽  
Author(s):  
Camila Oliveira Goulart ◽  
Daniella de Freitas Pereira Ângelo Durço ◽  
Lítia Alves de Carvalho ◽  
Júlia Teixeira Oliveira ◽  
Lucinéia Alves ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Cell Therapy ◽  
Nerve Regeneration ◽  
Nerve Transection ◽  
Glia Cell ◽  
Sciatic Nerve Transection ◽  
Olfactory Ensheathing Glia

scholarly journals Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shih-Tien Hsu ◽  
Chun-Hsu Yao ◽  
Yuan-Man Hsu ◽  
Jia-Horng Lin ◽  
Yung-Hsiang Chen ◽  
...  
Keyword(s):  
Growth Factors ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Transection ◽  
Cremophor El ◽  
Neuronal Connectivity ◽  
Sciatic Nerve Transection ◽  
Expression Levels ◽  
Nerve Growth Factors

Abstract Recent studies describe taxol as a candidate treatment for promoting central nerve regeneration. However, taxol has serious side effects including peripheral neurotoxicity, and little information is known about the effect of taxol on peripheral nerve regeneration. We investigated the effects of taxol on regeneration in a rat sciatic nerve transection model. Rats were divided into four groups (n = 10): normal saline (i.p.) as the control, Cremophor EL vehicle, and 2 or 6 mg/kg of taxol in the Cremophor EL solution (four times in day-2, 4, 6, and 8), respectively. We evaluated neuronal electrophysiology, animal behaviour, neuronal connectivity, macrophage infiltration, location and expression levels of calcitonin gene-related peptide (CGRP), and expression levels of both nerve growth factors and immunoregulatory factors. In the high-dose taxol group (6 mg/kg), neuronal electrophysiological function was significantly impaired. Licking latencies were significantly changed while motor coordination was unaffected. Neuronal connectivity, macrophage density, and expression levels of CGRP was dramatically reduced. Expression levels of nerve growth factors and immunoregulatory factors was also reduced, while it was increased in the low-dose taxol group (2 mg/kg). These results indicate that taxol can modulate local inflammatory conditions, impair nerve regeneration, and impede recovery of a severe peripheral nerve injury.

scholarly journals Promotion of nerve regeneration by biodegradable nanofibrous scaffold following sciatic nerve transection in rats

2021 ◽  
Vol 10 (1) ◽  
pp. 53-64
Author(s):  
Farshad Moharrami Kasmaie ◽  
Fatemeh Zamani ◽  
Sara Sayad-Fathi ◽  
Arash Zaminy
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Nanofibrous Scaffold ◽  
Nerve Transection ◽  
Sciatic Nerve Transection
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