scholarly journals Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats

2016 ◽  
Vol 1634 ◽  
pp. 132-139 ◽  
Author(s):  
Saad H. Mullah ◽  
Biswajit K. Saha ◽  
Rania Abutarboush ◽  
Peter B. Walker ◽  
Ashraful Haque ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Oxygen Tension ◽  
Cerebral Oxygen

Neurologic outcomes with cerebral oxygen monitoring in traumatic brain injury

Surgery ◽  
2009 ◽  
Vol 146 (4) ◽  
pp. 585-591 ◽  
Author(s):  
Mary C. McCarthy ◽  
Hugh Moncrief ◽  
Jean M. Sands ◽  
Ronald J. Markert ◽  
Lawrence C. Hall ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cerebral Oxygen ◽  
Neurologic Outcomes ◽  
Oxygen Monitoring

738 Early Cerebral Oxygen Desaturation in Traumatic Brain Injury with Normal Intracranial Pressure

Neurosurgery ◽  
2001 ◽  
Vol 49 (2) ◽  
pp. 517
Author(s):  
Sylvain Palmer ◽  
Mary Kay Bader ◽  
Jacques J. Palmer ◽  
Jeffrey Gross ◽  
Thomas Shaver ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Oxygen Desaturation ◽  
Cerebral Oxygen

Reduced cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and mild hemorrhage in cats

1992 ◽  
Vol 76 (5) ◽  
pp. 812-821 ◽  
Author(s):  
Douglas S. DeWitt ◽  
Donald S. Prough ◽  
Carol L. Taylor ◽  
John M. Whitley
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cardiac Output ◽  
Brain Injury ◽  
Renal Blood Flow ◽  
Oxygen Delivery ◽  
Cerebral Oxygen ◽  
Control Groups ◽  
Eeg Activity ◽  
Experimental Group

✓ The authors investigated the effects of transient, mild hemorrhagic hypotension after fluid-percussion traumatic brain injury on intracranial pressure, cerebral blood flow (CBF), cerebral oxygen delivery (CBF × arterial O2 content), and electroencephalographic (EEG) activity. Adult mongrel cats were anesthetized with 1.6% isoflurane in N2O:O2 (70:30) and prepared for trauma and for radioactive microsphere CBF measurement. Isoflurane concentration was decreased to 0.8%, and the cats were randomly assigned to one of four control groups or to an experimental group. Animals in the four control groups underwent either mild hemorrhage (18 ml · kg−1) immediately followed by resuscitation with equal volumes of 10% Hetastarch (eight cats), mild hemorrhage followed by replacement of shed blood (six cats), isovolemic hemodilution with 18 ml · kg−1 of Hetastarch (six cats), or moderate (2.2 atm) trauma alone (eight cats). The experimental group received a combination of trauma and mild hemorrhage followed by resuscitation with Hetastarch (eight cats). Mild hemorrhage produced no significant changes in CBF, renal blood flow, or cardiac output. Following resuscitation from mild hemorrhage, mean arterial blood pressure, cardiac output, renal blood flow, and CBF were not significantly different from baseline; cardiac output and renal blood flow did not differ significantly from baseline 2 hours after Hetastarch resuscitation. Neither hemorrhage nor trauma alone produced significant decreases in CBF or in EEG activity, but trauma followed by hemorrhage and resuscitation produced significant (p < 0.01) decreases in CBF, cerebral oxygen delivery, and EEG score. These data demonstrate that, following traumatic brain injury, even mild hemorrhagic hypotension is associated with significant deficits in cerebral oxygen availability and neurological function.

The Effect of Increased Inspired Fraction of Oxygen on Brain Tissue Oxygen Tension in Children with Severe Traumatic Brain Injury

2010 ◽  
Vol 12 (3) ◽  
pp. 430-437 ◽  
Author(s):  
Anthony A. Figaji ◽  
Eugene Zwane ◽  
A. Graham Fieggen ◽  
Andrew C. Argent ◽  
Peter D. Le Roux ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Tissue ◽  
Oxygen Tension ◽  
Severe Traumatic Brain Injury ◽  
Tissue Oxygen Tension ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen ◽  
Brain Tissue Oxygen Tension
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