scholarly journals BDNF may play a differential role in the protective effect of the mGluR2/3 agonist LY379268 on striatal projection neurons in R6/2 Huntington's disease mice

2012 ◽  
Vol 1473 ◽  
pp. 161-172 ◽  
Author(s):  
A. Reiner ◽  
H.B. Wang ◽  
N. Del Mar ◽  
K. Sakata ◽  
W. Yoo ◽  
...  
Keyword(s):  
Protective Effect ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Projection Neurons ◽  
Striatal Projection Neurons

Article Commentary: Development of the Human Striatum: Implications for Fetal Striatal Transplantation in the Treatment of Huntington's Disease

1995 ◽  
Vol 4 (6) ◽  
pp. 539-545
Author(s):  
Thomas B. Freeman ◽  
Paul R. Sanberg ◽  
Ole Isacson
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Fetal Tissue ◽  
The Body ◽  
Projection Neurons ◽  
Foramen Of Monro ◽  
Behavioral Deficits ◽  
Fetal Tissue Transplantation ◽  
Striatal Projection Neurons ◽  
Graft Success

Fetal neural transplantation has recently been demonstrated to ameliorate motor and other behavioral deficits in animal models of Huntington's disease, and reconstruct many of the damaged striatal circuits. However, there has been significant variability in the histological appearance of these grafts, most likely related to differences of the regions of dissection of the donor tissue. Selective dissection and transplantation of the lateral ventricular eminence in rodents has resulted in grafts consisting of primarily striatal-like tissue. This data, combined with data from our own and other laboratories has led to a description of the development of the human striatum, with a particular emphasis on the relevance of human striatal development to the field of fetal tissue transplantation for the treatment of Huntington's disease. If the goal of transplantation is to graft GABAergic striatal projection neurons, it is our impression that optimal grafting results will occur when transplants are derived from the lateral ventricular eminence and the lateral aspect of the body of the ventricular eminence anterior to the foramen of Monro. Optimal results are likely to occur when donor ages range from Stage 19 to 23, with possible graft success when donor age extends to as late as postovulatory week 22.

Abnormalities of Striatal Projection Neurons andN-Methyl-D-Aspartate Receptors in Presymptomatic Huntington's Disease

1990 ◽  
Vol 322 (18) ◽  
pp. 1293-1298 ◽  
Author(s):  
Roger L. Albin ◽  
Anne B. Young ◽  
John B. Penney ◽  
Barbara Handelin ◽  
Rosemary Balfour ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Projection Neurons ◽  
Striatal Projection Neurons

Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington’s disease

Neuroscience ◽  
2000 ◽  
Vol 98 (1) ◽  
pp. 89-96 ◽  
Author(s):  
E Pérez-Navarro ◽  
P Åkerud ◽  
S Marco ◽  
J.M Canals ◽  
E Tolosa ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Rat Model ◽  
Projection Neurons ◽  
Striatal Projection Neurons

scholarly journals Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

1992 ◽  
Vol 31 (4) ◽  
pp. 425-430 ◽  
Author(s):  
Roger L. Albin ◽  
Anton Reiner ◽  
Keith D. Anderson ◽  
Leon S. Dure ◽  
Barbara Handelin ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Projection Neurons ◽  
Preferential Loss
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