scholarly journals Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty

2012 ◽  
Vol 1450 ◽  
pp. 11-23 ◽  
Author(s):  
Nicole Sabaliauskas ◽  
Hui Shen ◽  
Gregg E. Homanics ◽  
Sheryl S. Smith ◽  
Chiye Aoki
Keyword(s):  
Pyramidal Cells ◽  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Acid Receptor ◽  
Extrasynaptic Receptors ◽  
Hippocampal Pyramidal Cells

scholarly journals Effect of Androgens on Sexual Differentiation of Pituitary Gamma-Aminobutyric Acid Receptor Subunit GABAB Expression

2004 ◽  
Vol 80 (3) ◽  
pp. 129-142 ◽  
Author(s):  
María S. Bianchi ◽  
Paolo N. Catalano ◽  
María M. Bonaventura ◽  
Patricia Silveyra ◽  
Bernhard Bettler ◽  
...  
Keyword(s):  
Sexual Differentiation ◽  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Gamma Aminobutyric Acid ◽  
Acid Receptor

scholarly journals Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Katalin Kerti-Szigeti ◽  
Zoltan Nusser
Keyword(s):  
Gabaa Receptor ◽  
Initial Segment ◽  
Pyramidal Cells ◽  
Immunogold Labeling ◽  
Receptor Subunit ◽  
Decay Kinetics ◽  
Active Zones ◽  
Α1 Subunit ◽  
Gabaar Subunit ◽  
Hippocampal Pyramidal Cells

Hippocampal pyramidal cells (PCs) express many GABAAR subunit types and receive GABAergic inputs from distinct interneurons. Previous experiments revealed input-specific differences in α1 and α2 subunit densities in perisomatic synapses, suggesting distinct IPSC decay kinetics. However, IPSC decays evoked by axo-axonic, parvalbumin- or cholecystokinin-expressing basket cells were found to be similar. Using replica immunogold labeling, here we show that all CA1 PC somatic and AIS synapses contain the α1, α2, β1, β2, β3 and γ2 subunits. In CA3 PCs, 90% of the perisomatic synapses are immunopositive for the α1 subunit and all synapses are positive for the remaining five subunits. Somatic synapses form unimodal distributions based on their immunoreactivity for these subunits. The α2 subunit densities in somatic synapses facing Cav2.1 (i.e. parvalbumin) or Cav2.2 (cholecystokinin) positive presynaptic active zones are comparable. We conclude that perisomatic synapses made by three distinct interneuron types have similar GABAA receptor subunit content.

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