Impairment of spatial learning and memory in transgenic mice overexpressing human fibroblast growth factor-23

2011 ◽  
Vol 1412 ◽  
pp. 9-17 ◽  
Author(s):  
Peidang Liu ◽  
Ling Chen ◽  
Xiuying Bai ◽  
Andrew Karaplis ◽  
Dengshun Miao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Fibroblast Growth Factor ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Human Fibroblast ◽  
Fibroblast Growth Factor 23 ◽  
Spatial Learning And Memory ◽  
Fibroblast Growth

scholarly journals Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders

Endocrinology ◽  
2004 ◽  
Vol 145 (11) ◽  
pp. 5269-5279 ◽  
Author(s):  
Xiuying Bai ◽  
Dengshun Miao ◽  
Jiarong Li ◽  
David Goltzman ◽  
Andrew C. Karaplis
Keyword(s):  
Vitamin D ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Fibroblast Growth Factor ◽  
Calcium Homeostasis ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Vitamin D Metabolism ◽  
Dihydroxyvitamin D3 ◽  
Circulating Levels

Abstract Fibroblast growth factor 23 (FGF23) is a recently characterized protein likely involved in the regulation of serum phosphate homeostasis. Increased circulating levels of FGF23 have been reported in patients with renal phosphate-wasting disorders, but it is unclear whether FGF23 is the direct mediator responsible for the decreased phosphate transport at the proximal renal tubules and the altered vitamin D metabolism associated with these states. To examine this question, we generated transgenic mice expressing and secreting from the liver human FGF23 (R176Q), a mutant form that fails to be degraded by furin proteases. At 1 and 2 months of age, mice carrying the transgene recapitulated the biochemical (decreased urinary phosphate reabsorption, hypophosphatemia, low serum 1,25-dihydroxyvitamin D3) and skeletal (rickets and osteomalacia) alterations associated with these disorders. Unexpectantly, marked changes in parameters of calcium homeostasis were also observed, consistent with secondary hyperparathyroidism. Moreover, in the kidney the anticipated alterations in the expression of hydroxylases associated with vitamin D metabolism were not observed despite the profound hypophosphatemia and increased circulating levels of PTH, both major physiological stimuli for 1,25-dihydroxyvitamin D3 production. Our findings strongly support the novel concept that high circulating levels of FGF23 are associated with profound disturbances in the regulation of phosphate and vitamin D metabolism as well as calcium homeostasis and that elevated PTH levels likely also contribute to the renal phosphate wasting associated with these disorders.

scholarly journals Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Endocrinology ◽  
2002 ◽  
Vol 143 (5) ◽  
pp. 1741-1747 ◽  
Author(s):  
Elizabeth Tomlinson ◽  
Ling Fu ◽  
Linu John ◽  
Bruce Hultgren ◽  
Xiaojian Huang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transgenic Mice ◽  
Metabolic Rate ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

scholarly journals Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1α,25-Dihydroxyvitamin D3Production

2002 ◽  
Vol 278 (4) ◽  
pp. 2206-2211 ◽  
Author(s):  
Hitoshi Saito ◽  
Kenichiro Kusano ◽  
Masahiko Kinosaki ◽  
Hirotaka Ito ◽  
Michinori Hirata ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Transport Activity

scholarly journals Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Haematologica ◽  
2017 ◽  
Vol 102 (11) ◽  
pp. e427-e430 ◽  
Author(s):  
Erica L. Clinkenbeard ◽  
Mark R. Hanudel ◽  
Keith R. Stayrook ◽  
Hitesh Nidumanda Appaiah ◽  
Emily G. Farrow ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth

Sex and iron modify fibroblast growth factor 23 concentrations in 1-year-old children

2017 ◽  
Author(s):  
Elisa Holmlund-Suila ◽  
Maria Enlund-Cerullo ◽  
Saara Valkama ◽  
Helena Hauta-alus ◽  
Jenni Rosendahl ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth
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