Acute ether stress differentially affects corticotropin-releasing factor and urocortin 1 in the Brattleboro rat

2011 ◽  
Vol 1398 ◽  
pp. 21-29 ◽  
Author(s):  
Linda Sterrenburg ◽  
Alexandra Borch ◽  
Bernard W.M.M. Peeters ◽  
Ottó Pintér ◽  
Dóra Zelena ◽  
...  
Keyword(s):  
Corticotropin Releasing Factor ◽  
Brattleboro Rat ◽  
Urocortin 1

Sa1859 Expression of Urocortin 1 and Corticotropin-Releasing Factor Receptors in Gastrointestinal Tract of Patients With Crohn's Disease

2016 ◽  
Vol 150 (4) ◽  
pp. S383
Author(s):  
Burcu Hasdemir ◽  
Elizabeth Garnett ◽  
Gregory Victorino ◽  
Nina Holland ◽  
Mel Heyman ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Corticotropin Releasing Factor ◽  
Urocortin 1

De novo Expression of Urocortin 1 in Acinar Cells: Ucn1 Promotes Inflammation via Corticotropin-Releasing Factor Receptor 2 (CRF 2 ) in Acute Pancreatitis

2011 ◽  
Vol 140 (5) ◽  
pp. S-385
Author(s):  
Eric Kubat ◽  
Eileen F. Grady ◽  
Victoria Lyo ◽  
Min Liao ◽  
Kimberly S. Kirkwood ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
De Novo ◽  
Acinar Cells ◽  
Corticotropin Releasing Factor ◽  
Urocortin 1

scholarly journals mRNA expression of corticotropin-releasing factor and urocortin 1 after restraint and foot shock together with alprazolam administration

Peptides ◽  
2010 ◽  
Vol 31 (12) ◽  
pp. 2200-2208 ◽  
Author(s):  
Isabel C. Cespedes ◽  
Amanda R. de Oliveira ◽  
Joelcimar M. da Silva ◽  
André V. da Silva ◽  
Luciane V. Sita ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Corticotropin Releasing Factor ◽  
Urocortin 1

scholarly journals Corticotropin-releasing factor, urocortin 1, and their receptors in the mouse spinal cord

2007 ◽  
Vol 502 (6) ◽  
pp. 973-989 ◽  
Author(s):  
Aniko Korosi ◽  
Tamás Kozicz ◽  
Jakub Richter ◽  
Jan G. Veening ◽  
Berend Olivier ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Corticotropin Releasing Factor ◽  
Mouse Spinal Cord ◽  
Urocortin 1

scholarly journals Corticotropin-Releasing Factor Is Cytoprotective in Xenopus Tadpole Tail: Coordination of Ligand, Receptor, and Binding Protein in Tail Muscle Cell Survival

Endocrinology ◽  
2006 ◽  
Vol 147 (3) ◽  
pp. 1498-1507 ◽  
Author(s):  
Graham C. Boorse ◽  
Cyrus A. Kholdani ◽  
Audrey F. Seasholtz ◽  
Robert J. Denver
Keyword(s):  
Binding Protein ◽  
Explant Culture ◽  
Corticotropin Releasing Factor ◽  
Environmental Stressors ◽  
Crf1 Receptor ◽  
Tadpole Tail ◽  
Locomotory Organ ◽  
Urocortin 1 ◽  
Tail Muscle

Upon metamorphosis, amphibian tadpoles lose their tails through programmed cell death induced by thyroid hormone (T3). Before transformation, the tail functions as an essential locomotory organ. The binding protein for the stress neuropeptide corticotropin-releasing factor (CRF; CRF-BP) is strongly up-regulated in the tail of Xenopus tadpoles during spontaneous or T3-induced metamorphosis. This finding led us to investigate physiological roles for CRF and CRF-BP in tadpole tail. We found CRF, CRF-BP, and functional CRF1 receptor in tail and CRF and functional CRF1 receptors, but not CRF-BP, in the tail muscle-derived cell line XLT-15. CRF, acting via the CRF1 receptor, slowed spontaneous tail regression in explant culture and caused a reduction in caspase 3/7 activity. CRF increased, but stable CRF-BP overexpression decreased, [3H]thymidine incorporation in XLT-15 cells. Overexpression of CRF-BP in vivo accelerated the loss of tail muscle cells during spontaneous metamorphosis. Lastly, exposure of tail explants to hypoxia increased CRF and urocortin 1 but strongly decreased CRF-BP mRNA expression. We show that CRF is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective. The inhibitory binding protein for CRF is regulated by hormones or by environmental stressors and can modulate CRF bioactivity.

scholarly journals Altered Responses to Cold Environment in Urocortin 1 and Corticotropin-Releasing Factor Deficient Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Bayan Chaker ◽  
Tareq A. Samra ◽  
Nabanita S. Datta ◽  
Abdul B. Abou-Samra
Keyword(s):  
Protein Metabolism ◽  
Core Body Temperature ◽  
Corticotropin Releasing Factor ◽  
Dexamethasone Treatment ◽  
Male And Female ◽  
Dramatic Decline ◽  
Urocortin 1 ◽  
Core Body ◽  
Deficient Mice

We examined core body temperature (CBT) of urocortin 1 (UCN1) and corticotropin releasing factor (CRF) knockout (KO) mice exposed to 4°C for 2 h. UCN1KO mice showed higher average CBT during cold exposure as compared to WT. The CBT of male and female WT mice dropped significantly to 34.1 ± 2.4 and 34.9 ± 3.1 C at 4°C, respectively. In contrast, the CBT of male and female UCN1KO mice dropped only slightly after 2 h at 4°C to 36.8 ± 0.7 and 38.1 ± 0.5 C, respectively. WT female and male UCN1KO mice showed significant acclimatization to cold; however, female UCN1KO mice did not show such a significant acclimatization. CRFKO mice showed a dramatic decline in CBT from 38.2 ±  0.4 at 22°C to 26.1 ± 9.8 at 4°C for 2 h. The CRF/UCN1 double KO (dKO) mice dropped their CBT to 32.5 ± 4.0 after 2 h exposure to 4°C. Dexamethasone treatment prevented the decline in CBT of the CRFKO and the dKO mice. Taken together, the data suggest a novel role for UCN1 in thermoregulation. The role of CRF is likely secondary to adrenal glucocorticoids, which have an important regulatory role on carbohydrate, fat, and protein metabolism.

scholarly journals Corticotropin-releasing factor receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Frank M. Dautzenberg ◽  
Dimitri E. Grigoriadis ◽  
Richard L. Hauger ◽  
Victoria B. Risbrough ◽  
Thomas Steckler ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Small Molecules ◽  
Corticotropin Releasing Factor ◽  
Releasing Hormone ◽  
Endogenous Peptides ◽  
Amino Acid Peptide ◽  
Kd Values ◽  
Urocortin 1 ◽  
Urocortin 3

Corticotropin-releasing factor (CRF, nomenclature as agreed by the NC-IUPHAR subcommittee on Corticotropin-releasing Factor Receptors [30]) receptors are activated by the endogenous peptides corticotrophin-releasing hormone, a 41 amino-acid peptide, urocortin 1, 40 amino-acids, urocortin 2, 38 amino-acids and urocortin 3, 38 amino-acids. CRF1 and CRF2 receptors are activated non-selectively by CRH and UCN. CRF2 receptors are selectively activated by UCN2 and UCN3. Binding to CRF receptors can be conducted using radioligands [125I]Tyr0-CRF or [125I]Tyr0-sauvagine with Kd values of 0.1-0.4 nM. CRF1 and CRF2 receptors are non-selectively antagonized by α-helical CRF, D-Phe-CRF-(12-41) and astressin. CRF1 receptors are selectively antagonized by small molecules NBI27914, R121919, antalarmin, CP 154,526, CP 376,395. CRF2 receptors are selectively antagonized by antisauvagine and astressin 2B.

Social isolation modulates corticotropin-releasing factor type 2 receptor, urocortin 1 and urocortin 2 mRNAs expression in the cardiovascular system of prairie voles

Peptides ◽  
2009 ◽  
Vol 30 (5) ◽  
pp. 940-946 ◽  
Author(s):  
Hossein Pournajafi-Nazarloo ◽  
Leila Partoo ◽  
Lisa Sanzenbacher ◽  
Maryam Esmaeilzadeh ◽  
Jamespaul Paredes ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Social Isolation ◽  
Corticotropin Releasing Factor ◽  
Prairie Voles ◽  
Urocortin 1 ◽  
Factor Type
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