Protective effects of ascorbic acid against lead-induced apoptotic neurodegeneration in the developing rat hippocampus in vivo

2007 ◽  
Vol 1185 ◽  
pp. 68-74 ◽  
Author(s):  
Jung-Mi Han ◽  
Byung-Joon Chang ◽  
Tian-Zhu Li ◽  
Nong-Hoon Choe ◽  
Fu-Shi Quan ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Rat Hippocampus ◽  
Protective Effects ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

Protective effects of ascorbic acid and garlic extract against lead-induced apoptosis in developing rat hippocampus

2016 ◽  
Vol 31 (5) ◽  
pp. 1123-1132 ◽  
Author(s):  
Ali-Reza Ebrahimzadeh-Bideskan ◽  
Javad Hami ◽  
Fatemeh Alipour ◽  
Hossein Haghir ◽  
Ali-Reza Fazel ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Garlic Extract ◽  
Rat Hippocampus ◽  
Protective Effects ◽  
Induced Apoptosis ◽  
Developing Rat

Protective Effects of Methylxanthines on Hypoxia-Induced Apoptotic Neurodegeneration and Long-Term Cognitive Functions in the Developing Rat Brain

Neonatology ◽  
2010 ◽  
Vol 98 (2) ◽  
pp. 128-136 ◽  
Author(s):  
Abdullah Kumral ◽  
Didem Cemile Yesilirmak ◽  
Simge Aykan ◽  
Sermin Genc ◽  
Kazim Tugyan ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cognitive Functions ◽  
Protective Effects ◽  
Developing Rat ◽  
Apoptotic Neurodegeneration

scholarly journals In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus

2005 ◽  
Vol 156 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Lakshmi Raman ◽  
Ivan Tkac ◽  
Kathleen Ennis ◽  
Michael K. Georgieff ◽  
Rolf Gruetter ◽  
...  
Keyword(s):  
Chronic Hypoxia ◽  
Rat Hippocampus ◽  
Neurochemical Profile ◽  
Developing Rat

In vitro and in vivo reduction of erythrocyte sorbitol by ascorbic acid

Diabetes ◽  
1989 ◽  
Vol 38 (8) ◽  
pp. 1036-1041 ◽  
Author(s):  
J. A. Vinson ◽  
M. E. Staretz ◽  
P. Bose ◽  
H. M. Kassm ◽  
B. S. Basalyga
Keyword(s):  
Ascorbic Acid

Antioxidant Activity, Phenolic Content and Hematoprotective Effects of Cleome arabica Polyphenolic Leaf Extract

2019 ◽  
Author(s):  
C. Tigrine ◽  
A. Kameli
Keyword(s):  
Antioxidant Activity ◽  
Biological Effects ◽  
Reducing Power ◽  
Hematological Toxicity ◽  
Protective Effects ◽  
Ferrous Ions ◽  
Polyphenolic Extract ◽  
Cleome Arabica

In this study a polyphenolic extract from Cleome arabica leaves (CALE) was investigated for its antioxidant activity in vitro using DPPH•, metal chelating and reducing power methods and for its protective effects against AraC-induced hematological toxicity in vivo using Balb C mice. Results indicated that CALE exhibited a strong and dose-dependent scavenging activity against the DPPH• free radical (IC50 = 4.88 μg/ml) and a high reducing power activity (EC50 = 4.85 μg/ml). Furthermore, it showed a good chelating effects against ferrous ions (IC50 = 377.75 μg/ml). The analysis of blood showed that subcutaneous injection of AraC (50 mg/kg) to mice during three consecutive days caused a significant myelosupression (P < 0.05). The combination of CALE and AraC protected blood cells from a veritable toxicity. Where, the number of the red cells, the amount of hemoglobin and the percentage of the hematocrite were significantly high. On the other hand, AraC cause an elevation of body temperature (39 °C) in mice. However, the temperature of the group treated with CALE and AraC remained normal and did not exceed 37.5 °C. The observed biological effects of CALE, in vitro as well as in vivo, could be due to the high polyphenol and flavonoid contents. In addition, the antioxidant activity of CALE suggested to be responsible for its hematoprotective effect.

Anthocyanins As Modulators of Cell Redox-Dependent Pathways in Non-Communicable Diseases

2020 ◽  
Vol 27 (12) ◽  
pp. 1955-1996 ◽  
Author(s):  
Antonio Speciale ◽  
Antonella Saija ◽  
Romina Bashllari ◽  
Maria Sofia Molonia ◽  
Claudia Muscarà ◽  
...  
Keyword(s):  
Human Health ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Antioxidant Defenses ◽  
Noncommunicable Diseases ◽  
Protective Effects ◽  
Pathological Conditions ◽  
Chronic Pulmonary Diseases ◽  
Underlying Mechanisms

: Chronic Noncommunicable Diseases (NCDs), mostly represented by cardiovascular diseases, diabetes, chronic pulmonary diseases, cancers, and several chronic pathologies, are one of the main causes of morbidity and mortality, and are mainly related to the occurrence of metabolic risk factors. Anthocyanins (ACNs) possess a wide spectrum of biological activities, such as anti-inflammatory, antioxidant, cardioprotective and chemopreventive properties, which are able to promote human health. Although ACNs present an apparent low bioavailability, their metabolites may play an important role in the in vivo protective effects observed. : This article directly addresses the scientific evidences supporting that ACNs could be useful to protect human population against several NCDs not only acting as antioxidant but through their capability to modulate cell redox-dependent signaling. In particular, ACNs interact with the NF-κB and AP-1 signal transduction pathways, which respond to oxidative signals and mediate a proinflammatory effect, and the Nrf2/ARE pathway and its regulated cytoprotective proteins (GST, NQO, HO-1, etc.), involved in both cellular antioxidant defenses and elimination/inactivation of toxic compounds, so countering the alterations caused by conditions of chemical/oxidative stress. In addition, supposed crosstalks could contribute to explain the protective effects of ACNs in different pathological conditions characterized by an altered balance among these pathways. Thus, this review underlines the importance of specific nutritional molecules for human health and focuses on the molecular targets and the underlying mechanisms of ACNs against various diseases.

Healing effects of curcumin nanoparticles in deep tissue injury mouse model.

2020 ◽  
Vol 18 ◽  
Author(s):  
Zirui Zhang ◽  
Shangcong Han ◽  
Panpan Liu ◽  
Xu Yang ◽  
Jing Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mrna Expression ◽  
Tissue Injury ◽  
Inflammatory Cells ◽  
Pcr Analysis ◽  
Protective Effects ◽  
Deep Tissue ◽  
Deep Tissue Injury

Background: Chronic inflammation and lack of angiogenesis are the important pathological mechanisms in deep tissue injury (DTI). Curcumin is a well-known anti-inflammatory and antioxidant agent. However, curcumin is unstable under acidic and alkaline conditions, and can be rapidly metabolized and excreted in the bile, which shortens its bioactivity and efficacy. Objective: This study aimed to prepare curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles (CPNPs) and to elucidate the protective effects and underlying mechanisms of wound healing in DTI models. Methods: CPNPs were evaluated for particle size, biocompatibility, in vitro drug release and their effect on in vivo wound healing. Results : The results of in vivo wound closure analysis revealed that CPNP treatments significantly improved wound contraction rates (p<0.01) at a faster rate than other three treatment groups. H&E staining revealed that CPNP treatments resulted in complete epithelialization and thick granulation tissue formation, whereas control groups resulted in a lack of compact epithelialization and persistence of inflammatory cells within the wound sites. Quantitative real-time PCR analysis showed that treatment with CPNPs suppressed IL-6 and TNF-α mRNA expression, and up-regulated TGF-β, VEGF-A and IL-10 mRNA expression. Western blot analysis showed up-regulated protein expression of TGF-β, VEGF-A and phosphorylatedSTAT3. Conclusion: Our results showed that CPNPs enhanced wound healing in DTI models, through modulation of the JAK2/STAT3 signalling pathway and subsequent upregulation of pro-healing factors.

Maternal diabetes-induced alterations in the expression of brain-derived neurotrophic factor in the developing rat hippocampus

2021 ◽  
Vol 114 ◽  
pp. 101946
Author(s):  
Reza Sardar ◽  
Javad Hami ◽  
Mansoureh Soleimani ◽  
Mohammad-Taghi Joghataei ◽  
Reza Shirazi ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Maternal Diabetes ◽  
Brain Derived Neurotrophic Factor ◽  
Rat Hippocampus ◽  
Developing Rat
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