Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumes

2006 ◽  
Vol 1114 (1) ◽  
pp. 125-137 ◽  
Author(s):  
Serge A. Mitelman ◽  
William Byne ◽  
Eileen M. Kemether ◽  
Randall E. Newmark ◽  
Erin A. Hazlett ◽  
...  
Keyword(s):  
Verbal Learning ◽  
Learning Task ◽  
Verbal Learning Task

Memory in a Mood-Inducing Verbal Learning Task

1990 ◽  
Vol 70 (1) ◽  
pp. 307-314 ◽  
Author(s):  
Robert Whissell ◽  
Kimberly Marshall ◽  
Cynthia Whissell
Keyword(s):  
Verbal Learning ◽  
Learning Task ◽  
Verbal Learning Task

Motivation, Anxiety and Stress in a Difficult Verbal Task

1965 ◽  
Vol 17 (1) ◽  
pp. 247-255 ◽  
Author(s):  
Gertrude R. Schmeidler ◽  
Stanley Ginsberg ◽  
Iris Bruel ◽  
Mary Lukomnik
Keyword(s):  
Negative Correlation ◽  
Significant Interaction ◽  
Verbal Learning ◽  
Significant Negative Correlation ◽  
Learning Task ◽  
Verbal Task ◽  
Achievement Scores ◽  
Need For Achievement ◽  
Verbal Learning Task

A complex verbal learning task was administered under stress or nonstress conditions to Ss shown by pre-tests to have either high or low scores on anxiety and need for achievement. Subsidiary findings from the pre-tests were that debilitating anxiety scores had a significant negative correlation with facilitating anxiety scores, and also with achievement scores. The verbal learning showed a significant interaction with “drive” variables: Ss high in need for achievement performed better if anxiety and stress were high but Ss low in need for achievement performed better if anxiety and stress were low. Ss high on only one or two drive variables showed significantly poorer learning than the pool of Ss high on all three or low on all three drive variables.

scholarly journals Dorsal Striatal Size, Shape, and Metabolic Rate in Never-Medicated and Previously Medicated Schizophrenics Performing a Verbal Learning Task

1998 ◽  
Vol 55 (3) ◽  
pp. 235 ◽  
Author(s):  
Lina Shihabuddin ◽  
Monte S. Buchsbaum ◽  
Erin A. Hazlett ◽  
M. Mehmet Haznedar ◽  
Philip D. Harvey ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Verbal Learning ◽  
Learning Task ◽  
Verbal Learning Task

Altered metabolism of cortical brodmann areas in schizophrenia during a verbal learning task

2000 ◽  
Vol 41 (1) ◽  
pp. 12
Author(s):  
I. Nenadic ◽  
M.S. Buchsbaum ◽  
M.B. Fleischman ◽  
A. Akhavan ◽  
L. Zhang ◽  
...  
Keyword(s):  
Verbal Learning ◽  
Learning Task ◽  
Brodmann Areas ◽  
Altered Metabolism ◽  
Verbal Learning Task

scholarly journals Virtual reality cognitive & functional assessment in psychosis

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S289-S290
Author(s):  
Sukhwinder Shergill ◽  
Lilla Porffy ◽  
Gabriella Whomersley ◽  
Timea Szentgyorgyi ◽  
Elias Mouchlianitis ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Side Effects ◽  
Verbal Learning ◽  
Learning Task ◽  
T Test ◽  
Composite Score ◽  
Healthy Controls ◽  
Everyday Functioning ◽  
Significant Difference ◽  
Verbal Learning Task

AimsTo compare the MATRICS Consensus Cognitive Battery (MCCB) and a novel Virtual Reality (VR) task, called VStore, in assessing cognition and functional capacity (FC) in schizophrenia. We hypothesise that VStore reliably discriminates between patients and controls, correlates with the MCCB, and is well-tolerated. Additionally, VStore is expected to strongly correlate with FC measures.BackgroundCognitive and functional deficits in schizophrenia have a major impact on everyday functioning of patients. The gold-standard cognitive assessment is the MCCB, while the USCD Performance-Based Skills Assessment (UPSA) is used to assess FC in this patient group. Neither of which are without limitations. For example, both take a long time to administer, and the MCCB alone cannot give clear indications of FC. We propose the use of a novel VR task to simultaneously measure cognition and FC in a single assessment. VStore is a shopping task, which involves a verbal learning task followed by buying items from a predetermined shopping list in a virtual minimarket.MethodTen patients with schizophrenia or schizoaffective disorder and ten age/gender-matched healthy controls recruited from South London, completed the following assessments: VStore, MCCB, UPSA & Global Assessment of Functioning (GAF), and VR-Symptom Questionnaire (VRSQ); while controls only completed the VR task. To test whether VStore can differentiate between patients and controls we employed unpaired t-test. To explore associations between VStore Total Time, MCCB composite score and FC measures Pearson's r was used. Finally, mean differences between pre/post-VR symptoms scores were tested using paired t-test.ResultThere was a significant difference between patients and controls on the verbal learning task (t16.38=−4.67,p < .001), and total time spent completing the VR task (t11.41 = 2.67, p = .023). In addition, VStore had a strong association with MCCB composite score (r=−.80,p = .010). While both VStore (r=−.82, p < 001) and MCCB (r = .77,p = .010) had significant correlation with the UPSA, only VStore had a significant association with the GAF (r=−.68,p = .030). Finally, VStore appears to be well-tolerated, causing no measurable side effects in the VRSQ (Pre-VR Mean =12.1[SD = 13.5], Post-VR Mean = 9.6[SD = 11.5],t9 = 0.49,p > .05).ConclusionResults suggest that VStore can discriminate between schizophrenia patients and healthy controls. In addition, VStore and MCCB seem to be strongly associated, suggesting that they tap into identical cognitive domains. VStore seems to be strongly correlated with FC, more so than the MCCB, and cause no measurable side effects. Taken together, this suggests that this novel VR task has the potential to reliably measure cognition and FC simultaneously.

Performance on a verbal learning task by subjects of heavy past marijuana usage

1974 ◽  
Vol 37 (4) ◽  
pp. 323-330 ◽  
Author(s):  
Michael J. Cohen ◽  
William H. Rickles
Keyword(s):  
Verbal Learning ◽  
Learning Task ◽  
Verbal Learning Task

scholarly journals No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers

2018 ◽  
Vol 33 (2) ◽  
pp. 210-218
Author(s):  
PRA Heckman ◽  
A Blokland ◽  
A Sambeth
Keyword(s):  
Healthy Volunteers ◽  
Cognitive Functions ◽  
Animal Studies ◽  
Verbal Learning ◽  
Learning Task ◽  
Healthy Human ◽  
Delayed Recall ◽  
Human Volunteers ◽  
Novelty Processing ◽  
Verbal Learning Task

Background: Animal literature suggests an interaction between acetylcholine and serotonin on cognitive functions. Aims: The aim of the current study was to assess whether both neurotransmitters interact during memory and novelty processing in humans. Methods: We tested the interaction between acetylcholine and serotonin on cognitive functions in healthy volunteers by means of treatment with rivastigmine and citalopram, respectively. Results: The main result of the study showed that during the verbal learning task participants significantly recalled fewer words after citalopram treatment than after rivastigmine or placebo during both the immediate and delayed recall tasks. Rivastigmine was not able to reverse the impairing effect of citalopram. Conclusions: This finding is in line with previous studies in which we manipulated acetylcholine and serotonin in different manners. Taken together, these studies in humans do not support the notion from animal studies that these two neurotransmitters interact on cognitive functions.

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