Ethanol activates cAMP response element-mediated gene expression in select regions of the mouse brain

2006 ◽  
Vol 1106 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Asma Asyyed ◽  
Daniel Storm ◽  
Ivan Diamond
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Camp Response Element ◽  
Response Element

LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells

2009 ◽  
Vol 296 (6) ◽  
pp. C1329-C1337 ◽  
Author(s):  
Mark D. Mattaliano ◽  
Christine Huard ◽  
Wei Cao ◽  
Andrew A. Hill ◽  
Wenyan Zhong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Human Aortic Endothelial Cell ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Camp Response Element ◽  
Response Element ◽  
Aortic Endothelial

Oxidized low-density lipoprotein (OxLDL) has been implicated as a proatherogenic factor with a pathological role in the induction of endothelial dysfunction. Endothelial cells bind and uptake OxLDL primarily through the scavenger receptor lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1), which is believed to mediate critical effects of OxLDL in endothelial cells. To examine the biological events following LOX-1 activation by OxLDL, we used cDNA microarray analysis to globally analyze gene expression changes induced by OxLDL treatment of human aortic endothelial cell line (HAECT) cells overexpressing LOX-1. Consistent with reported functions of OxLDL, in control HAECT cells, OxLDL elicited gene changes in the oxidative stress pathway and other signaling pathways related to OxLDL. With OxLDL treatment, LOX-1-dependent gene expression changes associated with inflammation, cell adhesion, and signal transduction were observed. The transcripts of a number of cytokines and chemokines were induced, which included interleukin-8, CXCL2, CXCL3, and colony-stimulating factor-3. The secretion of these cytokines was confirmed by enzyme-linked immunosorbent assay analysis. In addition, our data revealed a novel link between LOX-1 and a number of genes, including Delta/notch-like epidermal growth factor repeat containing, stanniocalcin-1, cAMP response element modulator, and dual specificity phosphatase 1. Promoter analysis on the genes that changed as a result of LOX-1 activation by OxLDL allowed us to identify early growth response 1 and cAMP response element-binding protein as potential novel transcription factors that function downstream of LOX-1. Our study has enabled us to elucidate the gene expression changes following OxLDL activation of LOX-1 in endothelial cells and discover novel downstream targets for LOX-1.

scholarly journals Upregulation of cAMP Response Element-Mediated Gene Expression during Experience-Dependent Plasticity in Adult Neocortex

2000 ◽  
Vol 20 (11) ◽  
pp. 4206-4216 ◽  
Author(s):  
Alison L. Barth ◽  
Mervyn McKenna ◽  
Stanislaw Glazewski ◽  
Penelope Hill ◽  
Soren Impey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Camp Response Element ◽  
Response Element ◽  
Dependent Plasticity

scholarly journals Activation of cAMP Response Element-Mediated Gene Expression by Regulated Nuclear Transport of TORC Proteins

2004 ◽  
Vol 14 (23) ◽  
pp. 2156-2161 ◽  
Author(s):  
Mark A. Bittinger ◽  
Elizabeth McWhinnie ◽  
Jodi Meltzer ◽  
Vadim Iourgenko ◽  
Brian Latario ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nuclear Transport ◽  
Camp Response Element ◽  
Response Element

scholarly journals cJun modulates Gγ-globin gene expression via an upstream cAMP response element

2010 ◽  
Vol 44 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Sirisha Kodeboyina ◽  
Parimaladevi Balamurugan ◽  
Li Liu ◽  
Betty S. Pace
Keyword(s):  
Gene Expression ◽  
Globin Gene ◽  
Camp Response Element ◽  
Response Element ◽  
Globin Gene Expression
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