Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein

2006 ◽  
Vol 1107 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Parul Shah ◽  
Bistra B. Nankova ◽  
Santosh Parab ◽  
Edmund F. La Gamma
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Creb Protein ◽  
Chain Fatty Acids

scholarly journals Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0154102 ◽  
Author(s):  
Lidiia Astakhova ◽  
Mtakai Ngara ◽  
Olga Babich ◽  
Aleksandr Prosekov ◽  
Lyudmila Asyakina ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Lymphoid Cells ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals FiberGrowth Pipeline: A Framework Toward Predicting Fiber-Specific Growth From Human Gut Bacteroidetes Genomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Bénédicte Colnet ◽  
Christian M. K. Sieber ◽  
Fanny Perraudeau ◽  
Marion Leclerc
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
False Positive Rate ◽  
Short Chain Fatty Acids ◽  
Glycoside Hydrolases ◽  
Short Chain ◽  
Bacterial Strains ◽  
Positive Rate ◽  
Chain Fatty Acids

Dietary fibers impact gut colonic health, through the production of short-chain fatty acids. A low-fiber diet has been linked to lower bacterial diversity, obesity, type 2 diabetes, and promotion of mucosal pathogens. Glycoside hydrolases (GHs) are important enzymes involved in the bacterial catabolism of fiber into short-chain fatty acids. However, the GH involved in glycan breakdown (adhesion, hydrolysis, and fermentation) are organized in polysaccharide utilization loci (PUL) with complex modularity. Our goal was to explore how the capacity of strains, from the Bacteroidetes phylum, to grow on fiber could be predicted from their genome sequences. We designed an in silico pipeline called FiberGrowth and independently validated it for seven different fibers, on 28 genomes from Bacteroidetes-type strains. To do so, we compared the existing GH annotation tools and built PUL models by using published growth and gene expression data. FiberGrowth’s prediction performance in terms of true positive rate (TPR) and false positive rate (FPR) strongly depended on available data and fiber: arabinoxylan (TPR: 0.89 and FPR: 0), inulin (0.95 and 0.33), heparin (0.8 and 0.22) laminarin (0.38 and 0.17), levan (0.3 and 0.06), mucus (0.13 and 0.38), and starch (0.73 and 0.41). Being able to better predict fiber breakdown by bacterial strains would help to understand their impact on human nutrition and health. Assuming further gene expression experiment along with discoveries on structural analysis, we hope computational tools like FiberGrowth will help researchers prioritize and design in vitro experiments.

scholarly journals Influenza infection impairs the gut’s barrier properties and favors secondary enteric bacterial infection through reduced production of short-chain fatty acids

2021 ◽  
Author(s):  
Valentin Sencio ◽  
Alexandre Gallerand ◽  
Marina Gomes Machado ◽  
Lucie Deruyter ◽  
Séverine Heumel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Influenza A ◽  
Influenza Infection ◽  
Intestinal Barrier ◽  
Barrier Properties ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

Along with respiratory tract disease per se , viral respiratory infections can also cause extrapulmonary complications with a potentially critical impact on health. In the present study, we used an experimental model of influenza A virus (IAV) infection to investigate the nature and outcome of the associated gut disorders. In IAV-infected mice, the signs of intestinal injury and inflammation, altered gene expression, and compromised intestinal barrier functions peaked on day 7 post-infection. As a likely result of bacterial component translocation, gene expression of inflammatory markers was upregulated in the liver. These changes occurred concomitantly with an alteration of the composition of the gut microbiota and with a decreased production of the fermentative, gut microbiota-derived, products short-chain fatty acids (SCFAs). Gut inflammation and barrier dysfunction during influenza were not attributed to reduced food consumption, which caused in part gut dysbiosis. Treatment of IAV-infected mice with SCFAs was associated with an enhancement of intestinal barrier properties, as assessed by a reduction in translocation of dextran and a decrease in inflammatory gene expression in the liver. Lastly, SCFA supplementation during influenza tended to reduce the translocation of the enteric pathogen Salmonella enterica serovar Typhimurium and to enhance the survival of doubly infected animals. Collectively, influenza infection can remotely impair the gut’s barrier properties and trigger secondary enteric infections. The latter phenomenon can be partially countered by SCFA supplementation.

Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression

2003 ◽  
Vol 31 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Evangelia Skarpidi ◽  
Hua Cao ◽  
Birgit Heltweg ◽  
Brian F White ◽  
Ronald L Marhenke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Globin Gene ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Derivatives Of ◽  
Globin Gene Expression ◽  
Chain Fatty Acids
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