Peroxisome proliferator-activated receptor-γ-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia

2006 ◽  
Vol 1093 (1) ◽  
pp. 208-218 ◽  
Author(s):  
Kon Chu ◽  
Soon-Tae Lee ◽  
Ja-Seong Koo ◽  
Keun-Hwa Jung ◽  
Eun-Hee Kim ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

Peroxisome proliferator-activated receptor γ promotes neuroprotection by modulating cyclic D1 expression after focal cerebral ischemia

2010 ◽  
Vol 88 (7) ◽  
pp. 716-723 ◽  
Author(s):  
Lichun Pei ◽  
Yanqiao Zhang ◽  
Yina Zhang ◽  
Xiaojie Chu ◽  
Jingyuan Zhang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cyclin D1 ◽  
Cortical Neurons ◽  
Focal Cerebral Ischemia ◽  
Substantial Contribution ◽  
Cortical Region ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Pparγ Agonist

Peroxisome proliferator-activated receptor γ (PPARγ) has been shown to protect against stroke and improve neurological outcome after cerebral ischemia. This study investigated whether activation of cerebral PPARγ improves recovery from focal cerebral ischemia by reducing expression of cyclin D1, which is associated with programmed neuron death. Focal cerebral ischemia was induced by 90 min of middle cerebral artery occlusion (MCAO), followed by reperfusion. Intracerebroventricular (i.c.v.) infusion of the PPARγ agonist ciglitazone, beginning 5 days before and continuing through 1 day after MCAO, reduced infarct size and cyclin D1 expression in the peri-infarct cortical region. Furthermore, primary cortical neurons treated with ciglitazone showed suppressed expression of cyclin D1 in response to hypoxia–reoxygenation. This protective effect was reversed after cotreatment with the selective PPAR-γ antagonist GW 9662 (2-chloro-5-nitrobenzanilide), clearly demonstrating the involvement of a PPARγ-dependent mechanism. Our data provide evidence that activation of neuronal PPARγ makes a substantial contribution to neuroprotection by preventing cyclin D1 up-regulation in vitro and in vivo.

scholarly journals MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice

2007 ◽  
Vol 20 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Jean-Baptiste Pialat ◽  
Tae-Hee Cho ◽  
Olivier Beuf ◽  
Elisabeth Joye ◽  
Samir Moucharaffie ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Deficient Mice

scholarly journals Erratum: MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice

2008 ◽  
Vol 21 (3) ◽  
pp. 301-301
Author(s):  
Jean-Baptiste Pialat ◽  
Tae-Hee Cho ◽  
Olivier Beuf ◽  
Elisabeth Joye ◽  
Samir Moucharaffie ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Deficient Mice
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