Effects of spinal cord injury on c-fos expression in hypothalamic paraventricular nucleus and supraoptic nucleus in rats

2006 ◽  
Vol 1087 (1) ◽  
pp. 175-179 ◽  
Author(s):  
Youjia Xu ◽  
Zugen Zheng ◽  
Kwok Ping Ho ◽  
Zhongming Qian
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Paraventricular Nucleus ◽  
Supraoptic Nucleus ◽  
Hypothalamic Paraventricular Nucleus ◽  
Cord Injury ◽  
Fos Expression

Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injury

2000 ◽  
Vol 279 (1) ◽  
pp. R295-R305 ◽  
Author(s):  
Margaret A. Vizzard
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Afferent Pathways ◽  
Spinal Cord Neurons ◽  
Bladder Distension ◽  
Lumbosacral Spinal Cord ◽  
Fos Protein ◽  
Cord Injury ◽  
Bladder Afferents ◽  
Fos Expression

These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after spinal cord injury (SCI). In urethan-anesthetized Wistar rats after SCI for 6 wk, intravesical saline distension significantly ( P ≤ 0.005) increased the number of Fos-immunoreactive (IR) cells in the rostrolumbar (L1, 38 cells/section; L2, 29 cells/section) and caudal lumbosacral (L6, 140 cells/section; S1, 110 cells/section) spinal cord compared with control animals, but Fos expression in the L5 segment was not altered. The distribution of Fos-IR cells was also altered in the lumbosacral spinal cord. Significantly greater numbers of Fos-IR cells were distributed in the dorsal commissure and medial and lateral dorsal horn after intravesical distension in SCI animals. Large percentages of parasympathetic (75%) and sympathetic (85%) preganglionic neurons also expressed Fos-IR after intravesical distension in SCI animals. These results demonstrate that bladder distension produces increased numbers and an altered distribution pattern of Fos-IR cells after SCI. This pattern resembles that after noxious irritation of the bladder in control animals. Pretreatment with capsaicin significantly reduced the number of Fos-IR cells induced by bladder distension after SCI. These data suggest that SCI can reveal an altered Fos expression pattern in response to a nonnoxious bladder stimulus that is partially mediated by capsaicin-sensitive bladder afferents.

scholarly journals c-fos Expression in Bladder-Specific Spinal Neurons after Spinal Cord Injury Using Pseudorabies Virus

2008 ◽  
Vol 49 (3) ◽  
pp. 479 ◽  
Author(s):  
Young Jae Im ◽  
Chang Hee Hong ◽  
Mei Hua Jin ◽  
Bong Hee Lee ◽  
Sang Won Han
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pseudorabies Virus ◽  
Spinal Neurons ◽  
Cord Injury ◽  
Fos Expression

C-fos expression in the spinal cord of rats exhibiting allodynia following contusive spinal cord injury

1999 ◽  
Vol 851 (1-2) ◽  
pp. 281-286 ◽  
Author(s):  
Philip J. Siddall ◽  
Cao Ling Xu ◽  
Nicole Floyd ◽  
Kevin A. Keay
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Contusive Spinal Cord Injury ◽  
Fos Expression
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