Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits

2006 ◽  
Vol 1088 (1) ◽  
pp. 141-147 ◽  
Author(s):  
Paul A. Lapchak
Keyword(s):  
Open Channel ◽  
Embolic Stroke ◽  
Stroke Model ◽  
Clinical Rating ◽  
Multiple Infarct

Selective MCA occlusion: A precise embolic stroke model

2006 ◽  
Vol 154 (1-2) ◽  
pp. 233-238 ◽  
Author(s):  
Vincent A. DiNapoli ◽  
Charles L. Rosen ◽  
Tomoaki Nagamine ◽  
Todd Crocco
Keyword(s):  
Embolic Stroke ◽  
Stroke Model ◽  
Mca Occlusion

scholarly journals microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66393 ◽  
Author(s):  
Fu Jia Liu ◽  
Kai Ying Lim ◽  
Prameet Kaur ◽  
Sugunavathi Sepramaniam ◽  
Arunmozhiarasi Armugam ◽  
...  
Keyword(s):  
Spontaneous Recovery ◽  
Embolic Stroke ◽  
Stroke Model

scholarly journals Thrombolytic activity of Cheonggukjang kinase on the recovery of brain damage in cerebral embolic stroke model

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Young‐Sun Song ◽  
Angela Melinda Anak Anthony Jalin ◽  
A Reum Kang ◽  
Chae Yeon Lee ◽  
Chung Mu Park ◽  
...  
Keyword(s):  
Brain Damage ◽  
Embolic Stroke ◽  
Stroke Model ◽  
Thrombolytic Activity

scholarly journals Reduction of infarct volume and mortality by thrombolysis in a rat embolic stroke model.

Stroke ◽  
1992 ◽  
Vol 23 (8) ◽  
pp. 1167-1173 ◽  
Author(s):  
K Overgaard ◽  
T Sereghy ◽  
G Boysen ◽  
H Pedersen ◽  
N H Diemer
Keyword(s):  
Infarct Volume ◽  
Embolic Stroke ◽  
Stroke Model

scholarly journals Effect of Delayed Thrombolysis with rt-PA in a Rat Embolic Stroke Model

1994 ◽  
Vol 14 (3) ◽  
pp. 472-477 ◽  
Author(s):  
Karsten Overgaard ◽  
Tomas Sereghy ◽  
Hans Pedersen ◽  
Gudrun Boysen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Thrombolytic Therapy ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Infarct Volume ◽  
Embolic Stroke ◽  
Stroke Model ◽  
Tissue Plasminogen ◽  
Before And After

The effect of delayed thrombolysis with recombinant tissue plasminogen activator was tested in an embolic stroke model. The carotid territory was embolized in 103 rats with fibrin-rich clots formed and washed in polyethylene tubes. Hemispheric cerebral blood flow before and after embolization was measured by the intra arterial 133Xe injection method. At five delay times, 15–240 min after embolization, 69 animals were treated with tissue plasminogen activator, 20 mg/kg, and 34 animals with saline. Carotid angiography displayed the grade of occlusion of the cerebral arterial supply before and after treatment. Brains were fixed after 2 days, evaluated neuropathologically, and infarct volume measured. Cerebral blood flow was reduced by 56–71% after embolization. Reperfusion induced by thrombolytic therapy was demonstrated by comparing the posttreatment angiography of the pooled five treatment groups to control animals. Thrombolytic therapy significantly reduced the infarct volume and improved the prekill clinical score by up to 2 h of treatment delay, and treatment might have been beneficial even after 4 h delay. Prolonging the delay of treatment increased the infarct volume ( p < 0.001, Jonckheere–Terpstra test). Only a few hemorrhagic complications were observed. Thus, thrombolytic therapy in embolic stroke induced recanalization. The effect on clinical outcome and infarct volume was dependent on delay time.

Sign in / Sign up

Export Citation Format

Share Document