Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats

2004 ◽  
Vol 1011 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Hao Chen ◽  
Arthur J Weber
Keyword(s):  
Optic Nerve ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush ◽  
Normal Retina

scholarly journals Overexpression of Brain-Derived Neurotrophic Factor Protects Large Retinal Ganglion Cells After Optic Nerve Crush in Mice

eNeuro ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. ENEURO.0331-16.2016 ◽  
Author(s):  
Liang Feng ◽  
Zhen Puyang ◽  
Hui Chen ◽  
Peiji Liang ◽  
John B. Troy ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Neurotrophic Factor ◽  
Ganglion Cells ◽  
Brain Derived Neurotrophic Factor ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush

Y-P30 confers neuroprotection after optic nerve crush in adult rats

Neuroreport ◽  
2011 ◽  
Vol 22 (11) ◽  
pp. 544-547 ◽  
Author(s):  
Tamar Macharadze ◽  
Peter Landgraf ◽  
Hans-Christian Pape ◽  
Petra Wahle ◽  
Michael R. Kreutz
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush

Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats

2014 ◽  
Vol 45 (5) ◽  
pp. 565-571 ◽  
Author(s):  
Fan Xu ◽  
Hui Huang ◽  
Yu Wu ◽  
Lu Lu ◽  
Li Jiang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush

Viability of retinal ganglion cells after optic nerve crush in adult rats

1984 ◽  
Vol 13 (3) ◽  
pp. 449-465 ◽  
Author(s):  
Louis J. Misantone ◽  
Mark Gershenbaum ◽  
Marion Murray
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush

scholarly journals Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Mira Chamoun ◽  
Elena G. Sergeeva ◽  
Petra Henrich-Noack ◽  
Shaobo Jia ◽  
Lisa Grigartzik ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Evoked Potentials ◽  
Visual Function ◽  
Cortical Plasticity ◽  
Brightness Discrimination ◽  
Acetylcholinesterase Inhibitor ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush

Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.

scholarly journals Intravitreal Co-Administration of GDNF and CNTF Confers Synergistic and Long-Lasting Protection against Injury-Induced Cell Death of Retinal Ganglion Cells in Mice

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2082 ◽  
Author(s):  
Simon Dulz ◽  
Mahmoud Bassal ◽  
Kai Flachsbarth ◽  
Kristoffer Riecken ◽  
Boris Fehse ◽  
...  
Keyword(s):  
Stem Cell ◽  
Optic Nerve ◽  
Cell Line ◽  
Retinal Ganglion Cells ◽  
Neural Stem Cell ◽  
Neurotrophic Factor ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush

We have recently demonstrated that neural stem cell-based intravitreal co-administration of glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) confers profound protection to injured retinal ganglion cells (RGCs) in a mouse optic nerve crush model, resulting in the survival of ~38% RGCs two months after the nerve lesion. Here, we analyzed whether this neuroprotective effect is long-lasting and studied the impact of the pronounced RGC rescue on axonal regeneration. To this aim, we co-injected a GDNF- and a CNTF-overexpressing neural stem cell line into the vitreous cavity of adult mice one day after an optic nerve crush and determined the number of surviving RGCs 4, 6 and 8 months after the lesion. Remarkably, we found no significant decrease in the number of surviving RGCs between the successive analysis time points, indicating that the combined administration of GDNF and CNTF conferred lifelong protection to injured RGCs. While the simultaneous administration of GDNF and CNTF stimulated pronounced intraretinal axon growth when compared to retinas treated with either factor alone, numbers of regenerating axons in the distal optic nerve stumps were similar in animals co-treated with both factors and animals treated with CNTF only.

The Expression Changes of Myelin and Lymphocyte Protein (MAL) Following Optic Nerve Crush in Adult Rats Retinal Ganglion Cells

2014 ◽  
Vol 54 (4) ◽  
pp. 614-621 ◽  
Author(s):  
Yongsheng Huang ◽  
Yue Xu ◽  
Qiaochu Cheng ◽  
Shanshan Yu ◽  
Yi Gao ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush
Sign in / Sign up

Export Citation Format

Share Document