Chronological dynamic changes in cortico-subcortical imbalance of cerebral blood flow in a boy with CAPOS syndrome

2019 ◽  
Vol 41 (7) ◽  
pp. 625-629
Author(s):  
Aya Hashimoto ◽  
Ichiro Kuki ◽  
Masataka Fukuoka ◽  
Kiyohiro Kim ◽  
Takeshi Inoue ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Dynamic Changes ◽  
Capos Syndrome

scholarly journals Relative contributions of systemic hemodynamic variables to cerebral autoregulation during orthostatic stress

2018 ◽  
Vol 124 (2) ◽  
pp. 321-329 ◽  
Author(s):  
Hisao Yoshida ◽  
Jason W. Hamner ◽  
Keita Ishibashi ◽  
Can Ozan Tan
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cardiac Output ◽  
Cerebral Blood Flow ◽  
Pressure Fluctuations ◽  
Dynamic Changes ◽  
Systemic Hemodynamic ◽  
Hemodynamic Variables ◽  
Central Volume ◽  
The Impact

Postural changes impair the ability of the cerebrovasculature to buffer against dynamic pressure fluctuations, but the mechanisms underlying this impairment have not been elucidated. We hypothesized that autoregulatory impairment may reflect the impact of static central volume shifts on hemodynamic factors other than arterial pressure (AP). In 14 young volunteers, we assessed the relation of fluctuations in cerebral blood flow (CBF) to those in AP, cardiac output, and CO2, during oscillatory lower body pressure (LBP) (±20 mmHg at 0.01 and 0.06 Hz) at three static levels (−20, 0, and +20 mmHg). Static and dynamic changes in AP, cardiac output, and CO2 explained over 70% of the variation in CBF fluctuations. However, their contributions were different across frequencies and levels: dynamic AP changes explained a substantial proportion of the variation in faster CBF fluctuations (partial R2 = 0.75, standardized β = 0.83, P < 0.01), whereas those in CO2 explained the largest portion of the variation in slow fluctuations (partial R2 = 0.43, β = 0.51, P < 0.01). There was, however, a major contribution of slow dynamic AP changes during negative (β = 0.43) but not neutral (β = 0.05) or positive (β = −0.07) LBP. This highlights the differences in contributions of systemic variables to dynamic and static autoregulation and has important implications for understanding orthostatic intolerance. NEW & NOTEWORTHY While fluctuations in blood pressure drive faster fluctuations in cerebral blood flow, overall level of CO2 and the magnitude of its fluctuations, along with cardiac output, determine the magnitude of slow ones. The effect of slow blood pressure fluctuations on cerebrovascular responses becomes apparent only during pronounced central volume shifts (such as when standing). This underlines distinct but interacting contributions of static and dynamic changes in systemic hemodynamic variables to the cerebrovascular regulation.

scholarly journals Dynamic Changes in Cerebral Blood Flow and Angiogenesis After Transient Focal Cerebral Ischemia in Rats

Stroke ◽  
2002 ◽  
Vol 33 (12) ◽  
pp. 2985-2991 ◽  
Author(s):  
Teng-Nan Lin ◽  
Shu-Wei Sun ◽  
Wai-Mui Cheung ◽  
Fuhai Li ◽  
Chen Chang
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Dynamic Changes ◽  
Transient Focal Cerebral Ischemia

Alterations in regional decreased cerebral blood flow in patients with irritable bowel syndrome-A PET imaging study

2001 ◽  
Vol 120 (5) ◽  
pp. A637-A637
Author(s):  
Y RINGEL ◽  
D DROSSMAN ◽  
T TURKINGTON ◽  
B BRADSHAW ◽  
R COLEMAN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Irritable Bowel Syndrome ◽  
Cerebral Blood Flow ◽  
Pet Imaging ◽  
Imaging Study ◽  
Irritable Bowel
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