Complete response of endemic Kaposi sarcoma lesions with high-dose-rate brachytherapy: Treatment method, results, and toxicity using skin surface applicators

Brachytherapy ◽  
2013 ◽  
Vol 12 (5) ◽  
pp. 495-499 ◽  
Author(s):  
Michael E. Kasper ◽  
Sam Richter ◽  
Nicholas Warren ◽  
Rashmi Benda ◽  
Charles Shang ◽  
...  
Brachytherapy ◽  
2011 ◽  
Vol 10 ◽  
pp. S75
Author(s):  
Michele Albert ◽  
Edvaldo Galhardo ◽  
Ramtin Zakikhani ◽  
Yong Zhu ◽  
Zhonglu Wang ◽  
...  

2017 ◽  
Vol 9 (6) ◽  
pp. 561-565 ◽  
Author(s):  
María Ángeles González Ruiz ◽  
Juan Quirós Rivero ◽  
Julia Luisa Muñoz García ◽  
Joaquín José Cabrera Rodríguez ◽  
Yesika Ríos Kavadoy ◽  
...  

Author(s):  
I. Membrive Conejo ◽  
O. Pera Cegarra ◽  
P. Foro Arnalot ◽  
A. Reig Castillejo ◽  
N. Rodríguez de Dios ◽  
...  

Abstract Purpose Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. Methods/patients We planned the treatment using two computed tomography (CT) scans: the first to delineate the lesion and the second after placing the thermoplastic mold. Fusing the two CT images enables planning of the target volume and pinpointing, where the catheters are in the mold. Results Seventy patients received plesiotherapy, either exclusively or following excision in patients with risk factors for recurrence. Those receiving plesiotherapy alone showed a complete response rate of 95.8%, and recurrences occurred in 5.7% at a mean follow-up of 96.2 months. Chronic toxicity appeared in 26.6% of patients, but severity was limited to grade 1 or 2. Conclusions High-dose-rate brachytherapy with customized molds yields a high rate of complete response, with long-term recurrence rates in line with similar studies and an acceptable toxicity rate.


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