Sector analysis of 125I permanent prostate brachytherapy provides a rapid and effective method of evaluating and comparing pre- and post-implant dosimetry

Brachytherapy ◽  
2013 ◽  
Vol 12 (3) ◽  
pp. 254-259 ◽  
Author(s):  
Ahamed Badusha Mohamed Yoosuf ◽  
Geraldine Workman ◽  
Monica M. O’Toole ◽  
Margaret Straney ◽  
Rejina Verghis ◽  
...  
Keyword(s):  
Prostate Brachytherapy ◽  
Sector Analysis

Use of sector analysis of I-125 permanent prostate brachytherapy to evaluate and compare pre- and postimplant dosimetry.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 242-242
Author(s):  
Ahamed Badusha Mohamed Yoosuf ◽  
Geraldine Workman ◽  
Monica M O'Toole ◽  
Margaret Straney ◽  
Rejina Verghis ◽  
...  
Keyword(s):  
Rapid Assessment ◽  
Target Volume ◽  
Planning System ◽  
Treatment Planning System ◽  
P Value ◽  
Prostate Brachytherapy ◽  
Dose Volume ◽  
Sector Analysis ◽  
Dose Homogeneity ◽  
Dosimetric Analysis

242 Background: To evaluate 12 sector analysis in the assessment and comparison of pre- and post- implant dosimetric parameters during the development of an I-125 prostate brachytherapy (PPB) service. Methods: 50 consecutive men being treated with PPB had dose volume analysis in 12 sectors of their pre implant ultrasound (PIUS) and post implant CT (PICT) data using a Variseed 8.0 treatment planning system. PIUS dosimetry was performed 2 weeks prior to implantation and PICT dosimetry 4 weeks post implant. Individual sectors were created by dividing the cranio-caudal prostate length into 3 equal lengths creating prostate base (PB), midgland (PM) and apex (PA). Each of these volumes was then divided into four axial sectors (right and left anterior, right and left posterior). The planning target volume (PTV), dose to 90% of prostate (D90), prostate volume enclosed by 100% (V100), 150% (V150) and 200% (V200) dose were recorded in each sector on PIUS and PICT. Adjacent sectors on PIUS were assessed for dose-volume homogeneity as were adjacent sectors on PICT. Differences in individual sectors on PIUS and PICT were evaluated. Results: Adjacent sector analysis demonstrated dose homogeneity in all sectors of PIUS and the majority of sectors on PICT. Statistically significant differences between PIUS and PICT were noted in target volume, particularly in PB with PICT >PIUS. When individual sectors on PIUS and PICT were compared, statistically significant differences were noted in the majority of dosimetric parameters. The anterior PB and PM were significantly lower on PICT (p value < 0.001) and significantly higher at the posterior PM and PA (p value < 0.05). These changes were consistent across all analysed parameters. In particular, significant absolute differences in D90 in equivalent sectors on PIUS and PICT were seen. Conclusions: 12 sector analysis allows rapid assessment of PIUS and PICT dose and volume homogeneity. It offers a scientific method of identifying areas of relative over and under dosing on PICT when compared with PIUS providing both clinicians and physicists with a learning tool to refine dosimetric analysis and highlight sectors where implant quality could be improved.

Sector analysis to provide additional spatial information on the permanent prostate brachytherapy learning curve.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 93-93
Author(s):  
Ahamed Badusha Mohamed Yoosuf ◽  
Sai Jonnada ◽  
Eoin Napier ◽  
Monica M. Byrne ◽  
Margaret A. Flynn ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Learning Curve ◽  
Spatial Information ◽  
Linear Regression Analysis ◽  
Prostate Brachytherapy ◽  
Single Institution ◽  
Sector Analysis ◽  
Dosimetric Analysis ◽  
Case Number

93 Background: To evaluate the spatial pattern of permanent prostate brachytherapy (PBT) learning curve using post-implant multi-sector dosimetric analysis. Methods: Two hundred patients treated with I-125 PBT at a single institution were assessed. A 12 sector analysis of post-implant CT was created for each case by dividing the prostate base, mid gland and apex into 4 sectors each. Dosimetric analysis was evaluated for whole prostate and individual sectors assessing: minimum dose to 90% of prostate (D90) and dose to 0.1 cm3 of the rectum (D0.1cc). Linear regression analysis and Pearson’s correlation co-efficient were used to investigate changes in D90with case number. Results: Global prostate analysis demonstrated a post-implant learning curve with significant improvement in D90 (p<0.01) in the last 50 cases (157.0 Gy ± 9.7) when compared to the initial 50 (141.6 Gy ± 14.5). Linear regression confirmed a significant improvement in global D90 with case number (r2=0.19, p=0.0001) at a rate of 0.11 Gy/case. Sector analysis demonstrated greatest improvement in base sectors with increasing case number with an improvement of 0.16 Gy/case (Table; p=0.049 when compared to global D90). Further, D90 in posterior mid-gland reduced with case number and correlated with reduced rectal D0.1cc. Conclusions: Sector analysis demonstrated increased spatial information on the PBT learning curve which may enable on-going improvements in implant quality. [Table: see text]

scholarly journals Comparison of implant quality between intraoperatively built custom-linked seeds and loose seeds in permanent prostate brachytherapy using sector analysis

2016 ◽  
Vol 57 (4) ◽  
pp. 393-399 ◽  
Author(s):  
Norihisa Katayama ◽  
Mitsuhiro Takemoto ◽  
Atsushi Takamoto ◽  
Hiroki Ihara ◽  
Kuniaki Katsui ◽  
...  
Keyword(s):  
Dose Calculation ◽  
Operation Time ◽  
Analysis Tool ◽  
Prostate Brachytherapy ◽  
Seed Implantation ◽  
Calculation Technique ◽  
Seed Migration ◽  
Dose Volume ◽  
Group A ◽  
Sector Analysis

Abstract We compared the implant quality of intraoperatively built custom-linked (IBCL) seeds with loose seeds in permanent prostate brachytherapy. Between June 2012 and January 2015, 64 consecutive prostate cancer patients underwent brachytherapy with IBCL seeds ( n = 32) or loose seeds ( n = 32). All the patients were treated with 144 Gy of brachytherapy alone. Brachytherapy was performed using a dynamic dose calculation technique. Computed tomography/magnetic resonance imaging fusion-based dosimetry was performed 1 month after brachytherapy. Post-implant dose–volume histogram (DVH) parameters, prostate sector dosimetry, operation time, seed migration, and toxicities were compared between the IBCL seed group and the loose seed group. A sector analysis tool was used to divide the prostate into six sectors (anterior and posterior sectors at the base, mid-gland, and apex). V100 (95.3% vs 89.7%; P = 0.014) and D90 (169.7 Gy vs 152.6 Gy; P = 0.013) in the anterior base sector were significantly higher in the IBCL seed group than in the loose seed group. The seed migration rate was significantly lower in the IBCL seed group than in the loose seed group (6% vs 66%; P &lt; 0.001). Operation time per seed was significantly longer in the IBCL seed group than in the loose seed group (1.31 min vs 1.13 min; P = 0.003). Other post-implant DVH parameters and toxicities did not differ significantly between the two groups. Our study showed more dose coverage post-operatively in the anterior base prostate sector and less seed migration in IBCL seed implantation compared with loose seed implantation.

scholarly journals EP-1999: Comparison of intraoperatively linked and loose seed in prostate brachytherapy using sector analysis

2016 ◽  
Vol 119 ◽  
pp. S945-S946
Author(s):  
N. Katayama ◽  
M. Takemoto ◽  
A. Takamoto ◽  
K. Hisazumi ◽  
H. Ihara ◽  
...  
Keyword(s):  
Prostate Brachytherapy ◽  
Sector Analysis

A sector-based postimplant dosimetric comparison of sagittal and axial ultrasound-guided source placement during I-125 permanent prostate brachytherapy.

2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 262-262
Author(s):  
Ahamed Badusha Mohamed Yoosuf ◽  
Darren M. Mitchell ◽  
Monica M. Byrne ◽  
Margaret A. Flynn ◽  
Eoin Napier ◽  
...  
Keyword(s):  
Prostate Volume ◽  
Prostate Brachytherapy ◽  
Dose Volume ◽  
Sector Analysis ◽  
Seed Deposition ◽  
The Difference ◽  
Group 2 ◽  
Dosimetric Analysis ◽  
Implant Technique ◽  
Group 1

262 Background: To use sector based pre- and postimplant dosimetric analysis to evaluate the effect of changes in implant technique in a developing I-125 permanent prostate brachytherapy program (PPB). Methods: 109 men treated with PPB were divided into two groups by implant technique. The first 50 patients (group 1) had needle-by-needle seed deposition under axial ultrasound (USS) guidance and subsequent 59 patients (group 2) having needle placement row-by-row then seed deposition under sagittal USS guidance. Twelve sector dose volume analysis of pre-implant ultrasound (USpre) and postimplant CT (CTpost) study was performed in all cases. Individual sectors were created by dividing the cranio-caudal prostate into three equal lengths creating prostate base, midgland and apex. Each of these volumes was then divided into four axial sectors (right and left anterior, right and left posterior). The difference in the minimum dose delivered to 90% of prostate volume (D90) and the prostate volume receiving 100%, 150%, and 200% of the prescribed dose (V100, V150, and V200) was compared between both groups. Results: In both groups, the volume of prostate in sectors one through six (entire base and anterior midgland) were significantly larger on CTpost when compared to equivalent sectors in USpre (p < 0.001), conversely the volumes in sectors 11 and 12 (posterior apex) were significantly smaller (p =0.001). When comparing dosimetric parameters of all equivalent sectors in CTpost of both groups, it was found that D90 of sector seven and eight (posterior midgland) in Group 1 received increased dose leading to elevated dose to the rectum but was significantly reduced in Group 2 (p < 0.01), which resulted in achieving the dose as planned in USpre. Prostate implant dosimetry was significantly improved in group 2 with a trend to increased equivalent dose between CTpost and USpre to each sectors and significant decrease in V150 and V200 in majority of the sectors. Conclusions: The row-by-row technique under sagittal USS guidance significantly improved our post implant dosimetric parameters when compared to single needle source placement under axial USS guidance as assessed by 12 sector analysis.

Sector Analysis of Prostate Brachytherapy Shows That Low Doses can Achieve an Undetectable PSA

2011 ◽  
Vol 81 (2) ◽  
pp. S422
Author(s):  
E.N. Christensen ◽  
T.J. Pugh ◽  
M.F. Munsell ◽  
D.A. Swanson ◽  
R.J. Kudchadker ◽  
...  
Keyword(s):  
Prostate Brachytherapy ◽  
Low Doses ◽  
Sector Analysis

Sector Analysis After Permanent Prostate Brachytherapy

Brachytherapy ◽  
2010 ◽  
Vol 9 ◽  
pp. S41
Author(s):  
Thomas G. Shanahan ◽  
Angela E. Shanahan ◽  
Hamzeh O. Badwan ◽  
Stephen J. Markwell ◽  
Paul W. Mueller ◽  
...  
Keyword(s):  
Prostate Brachytherapy ◽  
Sector Analysis

Sector analysis provides additional spatial information on the permanent prostate brachytherapy learning curve

Brachytherapy ◽  
2015 ◽  
Vol 14 (5) ◽  
pp. 703-710 ◽  
Author(s):  
Ahamed Badusha Mohamed Yoosuf ◽  
Darren M. Mitchell ◽  
Geraldine Workman ◽  
Sai Jonnada ◽  
Eoin Napier ◽  
...  
Keyword(s):  
Learning Curve ◽  
Spatial Information ◽  
Prostate Brachytherapy ◽  
Sector Analysis
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