A comparison of the biological effective dose of 50-kV electronic brachytherapy with 192Ir high-dose-rate brachytherapy for vaginal cuff irradiation

Brachytherapy ◽  
2012 ◽  
Vol 11 (5) ◽  
pp. 402-407 ◽  
Author(s):  
Paul Rava ◽  
Tomas Dvorak ◽  
Robert J. Markelewicz ◽  
Jessica R. Hiatt ◽  
Edward S. Sternick ◽  
...  
Keyword(s):  
Effective Dose ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Biological Effective Dose ◽  
Vaginal Cuff ◽  
High Dose Rate Brachytherapy ◽  
Electronic Brachytherapy

A comparison of the biological effective dose of 50 KV electronic brachytherapy to 192 Ir high-dose-rate brachytherapy for vaginal cuff irradiation

Brachytherapy ◽  
2009 ◽  
Vol 8 (2) ◽  
pp. 126-127
Author(s):  
Robert J. Markelewicz ◽  
Jessica R. Hiatt ◽  
Jaroslaw T. Hepel ◽  
Gene A. Cardarelli ◽  
Edward S. Sternick ◽  
...  
Keyword(s):  
Effective Dose ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Biological Effective Dose ◽  
Vaginal Cuff ◽  
High Dose Rate Brachytherapy ◽  
Electronic Brachytherapy

The Nature and Dosimetric Effect of Daily Variations in Vaginal Cuff High-Dose-Rate Brachytherapy: A Prospective Study

Brachytherapy ◽  
2010 ◽  
Vol 9 ◽  
pp. S89-S90
Author(s):  
M. Salim U. Siddiqui ◽  
Maria R. Bellon ◽  
Correen Fraser ◽  
Indrin J. Chetty ◽  
Mohamed A. Elshaikh
Keyword(s):  
Prospective Study ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Vaginal Cuff ◽  
High Dose Rate Brachytherapy ◽  
Daily Variations ◽  
A Prospective Study

Long-term outcomes of intensity-modulated radiation therapy (IMRT) and high dose rate brachytherapy as adjuvant therapy after radical hysterectomy for cervical cancer

2020 ◽  
Vol 30 (8) ◽  
pp. 1157-1161
Author(s):  
Jessika Contreras ◽  
Amar Srivastava ◽  
Anupama Chundury ◽  
Julie K Schwarz ◽  
Stephanie Markovina ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dose Rate ◽  
Radical Hysterectomy ◽  
Intensity Modulated Radiation Therapy ◽  
High Dose Rate ◽  
High Dose ◽  
Vaginal Cuff ◽  
High Dose Rate Brachytherapy ◽  
Intensity Modulated ◽  
Distant Failure

ObjectiveCompared with 3D-planned pelvic radiation, intensity-modulated radiation therapy (IMRT) has been shown to reduce acute toxicity in cervical cancer patients after radical hysterectomy. This study evaluated late toxicity and patterns of failure after post-operative pelvic IMRT interdigitated weekly with high dose rate brachytherapy.MethodsThis retrospective study included 53 cervical cancer patients treated between January 2006 and August 2019 with radical hysterectomy, lymphadenectomy, and post-operative IMRT and high dose rate brachytherapy. The decision to include chemotherapy was made by the treating gynecologic oncologist based on patient-specific criteria including positive pelvic lymph nodes, positive surgical margins, or positive parametrial invasion. The actuarial rates of genitourinary and gastrointestinal toxicity, vaginal cuff/regional nodal/distant failure, and overall survival were calculated using the Kaplan–Meier method.ResultsMedian follow-up was 70 months (range 5.4–148) months and age at diagnosis was 47 (range 24–73) years. The 2018 International Federation of Gynecology and Obstetrics (FIGO) clinical stages were IB1 (n=19), IB2 (n=7), IIB (n=7), IIIC1 (n=19), and IIIC2 (n=1). Median radiation dose delivered in 160 cGy daily fractions was 5120 (range 4640–5120) cGy. Median brachytherapy dose prescribed to the vaginal surface delivered in six weekly fractions was 2400 (range 1200–4800) cGy. Concurrent chemotherapy was delivered in 35 (66%) patients. There were no acute grade >3 genitourinary or gastrointestinal toxicities. Late grade >3 occurred in two (3.8%) patients, including a small bowel obstruction and a ureteral stricture. The 5-year actuarial rate for gastrointestinal or genitourinary toxicity was 1.9%. There were no vaginal cuff recurrences. The 5-year actuarial rates for regional nodal failure, distant failure outside the radiation field, any failure, and overall survival were 11%, 11%, 14%, and 85%, respectively.ConclusionsPost-operative IMRT with high dose rate brachytherapy for patients with cervical cancer is associated with excellent outcomes and limited rates of radiation-related non-hematologic toxicity.

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