Cholangiocarcinoma: The impact of endobiliary high-dose-rate (HDR) brachytherapy dose response on survival

Brachytherapy ◽  
2006 ◽  
Vol 5 (2) ◽  
pp. 91
Author(s):  
Matthew Biagioli ◽  
B-Chen Wen ◽  
Brandon Patton ◽  
Caroline Hoffman ◽  
Mark Harvey
Keyword(s):  
Dose Rate ◽  
Dose Response ◽  
High Dose Rate ◽  
High Dose ◽  
Hdr Brachytherapy ◽  
The Impact

The role of needle trauma to the neurovascular bundle region (NVB) and its impact on potency following high-dose-rate (HDR) brachytherapy

Brachytherapy ◽  
2007 ◽  
Vol 6 (2) ◽  
pp. 86
Author(s):  
Michel I. Ghilezan ◽  
J. Vito Antonucci ◽  
Gary S. Gustafson ◽  
Peter Chen ◽  
Michelle Wallace ◽  
...  
Keyword(s):  
Dose Rate ◽  
High Dose Rate ◽  
Neurovascular Bundle ◽  
High Dose ◽  
Hdr Brachytherapy

Interstitial High Dose Rate (HDR) Brachytherapy for Early Stage Breast Cancer: A Report of 136 Cases

2007 ◽  
Vol 69 (3) ◽  
pp. S229 ◽  
Author(s):  
P.J. Anderson ◽  
R.J. Mark ◽  
R.S. Akins ◽  
T.R. Neumann ◽  
S. Gurley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dose Rate ◽  
Early Stage ◽  
High Dose Rate ◽  
Early Stage Breast Cancer ◽  
High Dose ◽  
Hdr Brachytherapy

scholarly journals Impact of discrete source step size on the 3D dosimetry of interstitial implants with high dose rate brachytherapy

2018 ◽  
Vol 6 (3) ◽  
pp. 990 ◽  
Author(s):  
Anil Kumar Maurya ◽  
Rajesh Kumar Maurya ◽  
Surendrakumar Dayashankar Maurya ◽  
Radha Kesarwani ◽  
Virendra Singh
Keyword(s):  
Dose Rate ◽  
High Dose Rate ◽  
Planning System ◽  
High Dose ◽  
Quality Indices ◽  
Step Size ◽  
Mean Values ◽  
Dose Homogeneity ◽  
Dose Volumes ◽  
The Impact

ABSTRACTBackground: High dose rate remote after loading brachytherapy machines have seen tremendous advancement both technologically and their clinical applications during the last 25 years. With the introduction of computerized remote after loading machines and computerized planning system, stepping source dosimetry system (SSDS) has become the system of choice making almost all traditional dosimetry systems obsolete. In this study we evaluated the impact of source step size on dosimetry of interstitial implant using parameters of ICRU-58 and various quality indices (QI).Material & Methods: For this study, 10 implant cases which have 3-D CT image based planning were selected. Contouring of clinical target volume and various organs were done following standard guidelines for the same. Plans were optimized to achieve the desired clinical outcome using different source step sizes of 2.5, 5 and 10 mm respectively. Cumulative DVH’s were calculated for the estimation of various ICRU-58 parameters and quality indices.Results and Conclusion: The mean values of the target volumes, minimum target doses, treated volumes, low dose volumes; high dose volumes, overdose volumes, reference volumes, coverage, external volume, relative dose homogeneity, overdose volume and COIN indices have been presented for the source step sizes of 2.5 mm, 5 mm and 10 mm respectively. Among source step sizes used in this study, most favorable clinically acceptable dose distributions & dose homogeneity occurs around step size of 5 mm as predicted by the various parameters of ICRU-58 and dose quality indices. Keywords: Brachytherapy, interstitial implant, source step-size, remote after loading, optimization, quality indices.

scholarly journals Implementation of High Dose Rate Brachytherapy in Cancer Treatment

2021 ◽  
Vol 1 (3) ◽  
pp. 77-106
Author(s):  
Amir Shahabaz ◽  
Muhammad Afzal
Keyword(s):  
Radiation Therapy ◽  
Side Effects ◽  
Dose Rate ◽  
Radiation Source ◽  
Cancer Recurrence ◽  
High Dose Rate ◽  
High Dose ◽  
Hdr Brachytherapy ◽  
Short Treatment ◽  
High Dose Rate Brachytherapy

A technique of radiation therapy delivery in which the radioactive sources are placed very close or even inside the target volume is called Brachytherapy (BT). Brachytherapy is a type of radiation therapy. It destroys cancer cells by making it hard for them to multiply. In this technique, a radiation source is placed directly into or near a tumour. High dose-rate brachytherapy is also known as HDR brachytherapy, or temporary brachytherapy. It is a type of internal radiotherapy. HDR was developed to reduce the risk of cancer recurrence while shortening the amount of time it takes to get radiation treatment. HDR also limits the dose of radiation (associated side effects) to surrounding normal tissue. The important benefits of HDR brachytherapy include extremely precise radiation therapy delivered internally, used alone or after surgery to help prevent cancer recurrence, convenient treatments that are usually pain-free, and a reduction in the risk of common short- and long-term side effects. Currently, tumour dose, as well as doses of the surrounding normal structures, can be evaluated accurately, and high-dose-rate brachytherapy enables three-dimensional image guidance. The biological disadvantages of high-dose-rate were overcome by fractional irradiation. In the definitive radiation therapy of cervical cancer, high-dose-rate brachytherapy is most necessary. Most patients feel little discomfort during brachytherapy. There is no residual radioactivity when the treatment is completed. A patient may be able to go home shortly after the procedure, resuming his normal activities with few restrictions. An advantage of brachytherapy is to deliver a high dose to the tumour during treatment and save the surrounding normal tissues. High-dose-rate (HDR) brachytherapy has great promise with respect to proper case selection and delivery technique because it eliminates radiation exposure, can be performed on an outpatient basis and allows short treatment times. Additionally, by varying the dwell time at each dwell position, the use of a single-stepping source allows optimization of dose distribution. As the short treatment times do not allow any time for correction of errors, and mistakes can result in harm to patients, so the treatments must be executed carefully by using HDR brachytherapy. Refinements will occur primarily in the integration of imaging (computed tomography, magnetic resonance imaging, intraoperative ultrasonography) and optimization of dose distribution and it is expected that the use of HDR brachytherapy will greatly expand over the next decade. Various factors in the development of well-controlled randomized trials addressing issues of efficacy, quality of life, toxicity and costs-versus-benefits will ultimately define the role of HDR brachytherapy in the therapeutic armamentarium. Surrounding healthy tissues are not affected by the radiation due to the ability to target radiation therapy at high dose rates directly to the tumour. Treatment to be delivered as an outpatient in as few as one to five sessions is also allowed by this targeted high dose approach. HDR brachytherapy is the most precision radiation therapy, even better than carbon ion therapy. At the time of invasive placement of the radiation source into the tumour area, brachytherapy requires the skills and techniques of radiation oncologists.

Dosimetric evaluation of tandem-based cervical high-dose-rate brachytherapy treatment planning using American Brachytherapy Society 2011 recommendations

2016 ◽  
Vol 15 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Manish K. Goyal ◽  
T. S. Kehwar ◽  
Jayanand Manjhi ◽  
Jerry L. Barker ◽  
Bret H. Heintz ◽  
...  
Keyword(s):  
Linear Regression ◽  
Dose Rate ◽  
Regression Line ◽  
High Dose Rate ◽  
Least Square ◽  
High Dose ◽  
Hdr Brachytherapy ◽  
Linear Regression Line ◽  
Significant Difference ◽  
Best Fit

AbstractPurposeThis study evaluated dosimetric parameters for cervical high-dose-rate (HDR) brachytherapy treatment using varying dose prescription methods.MethodsThis study includes 125 tandem-based cervical HDR brachytherapy treatment plans of 25 patients who received HDR brachytherapy. Delineation of high-risk clinical target volumes (HR-CTVs) and organ at risk were done on original computed tomographic images. The dose prescription point was defined as per International Commission in Radiation Units and Measurements Report Number 38 (ICRU-38), also redefined using American Brachytherapy Society (ABS) 2011 criteria. The coverage index (V100) for each HR-CTV was calculated using dose volume histogram parameters. A plot between HR-CTV and V100was plotted using the best-fit linear regression line (least-square fit analysis).ResultsMean prescribed dose to ICRU-38 Point A was 590·47±28·65 cGy, and to ABS Point A was 593·35±30·42 cGy. There was no statistically significant difference between planned ICRU-38 and calculated ABS Point A doses (p=0·23). The plot between HR-CTV and V100is well defined by the best-fit linear regression line with a correlation coefficient of 0·9519.ConclusionFor cervical HDR brachytherapy, dose prescription to an arbitrarily defined point (e.g., Point A) does not provide consistent coverage of HR-CTV. The difference in coverage between two dose prescription approaches increases with increasing CTV. Our ongoing work evaluates the dosimetric consequences of volumetric dose prescription approaches for these patients.

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