scholarly journals Encoding of Contextual Fear Memory Requires De Novo Proteins in the Prelimbic Cortex

2017 ◽  
Vol 2 (2) ◽  
pp. 158-169 ◽  
Author(s):  
Valerio Rizzo ◽  
Khalid Touzani ◽  
Bindu L. Raveendra ◽  
Supriya Swarnkar ◽  
Joan Lora ◽  
...  
Keyword(s):  
De Novo ◽  
Fear Memory ◽  
Prelimbic Cortex ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
De Novo Proteins

PKMζ maintains remote contextual fear memory by inhibiting GluA2-dependent AMPA receptor endocytosis in the prelimbic cortex

Neuroscience ◽  
2021 ◽  
Author(s):  
Lucas A. Marcondes ◽  
Jociane de C. Myskiw ◽  
Eduarda G. Nachtigall ◽  
Rodrigo F. Narvaes ◽  
Ivan Izquierdo ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Fear Memory ◽  
Prelimbic Cortex ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Receptor Endocytosis

Hippocampus and Prefrontal Cortex Modulation of Contextual Fear Memory Is Dissociated by Inhibiting De Novo Transcription During Late Consolidation

2019 ◽  
Vol 56 (8) ◽  
pp. 5507-5519 ◽  
Author(s):  
Luciana M. Pereira ◽  
Caio M. de Castro ◽  
Lorena T. L. Guerra ◽  
Thaís M. Queiroz ◽  
João T. Marques ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
De Novo ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory

scholarly journals Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Nadine F. Joseph ◽  
Aya Zucca ◽  
Jenna L. Wingfield ◽  
Isabel Espadas ◽  
Damon Page ◽  
...  
Keyword(s):  
Molecular Motor ◽  
Fear Memory ◽  
Contextual Fear Conditioning ◽  
Prelimbic Cortex ◽  
Spine Density ◽  
Cellular Mechanisms ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
And Function

AbstractMolecular and cellular mechanisms underlying the role of the prelimbic cortex in contextual fear memory remain elusive. Here we examined the kinesin family of molecular motor proteins (KIFs) in the prelimbic cortex for their role in mediating contextual fear, a form of associative memory. KIFs function as critical mediators of synaptic transmission and plasticity by their ability to modulate microtubule function and transport of gene products. However, the regulation and function of KIFs in the prelimbic cortex insofar as mediating memory consolidation is not known. We find that within one hour of contextual fear conditioning, the expression of KIF3B is upregulated in the prelimbic but not the infralimbic cortex. Importantly, lentiviral-mediated knockdown of KIF3B in the prelimbic cortex produces deficits in consolidation while reducing freezing behavior during extinction of contextual fear. We also find that the depletion of KIF3B increases spine density within prelimbic neurons. Taken together, these results illuminate a key role for KIF3B in the prelimbic cortex as far as mediating contextual fear memory.

scholarly journals Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christina F. de Veij Mestdagh ◽  
Jaap A. Timmerman ◽  
Frank Koopmans ◽  
Iryna Paliukhovich ◽  
Suzanne S. M. Miedema ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Performance ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Model Of Alzheimer’S Disease ◽  
Term Potentiation

AbstractHibernation induces neurodegeneration-like changes in the brain, which are completely reversed upon arousal. Hibernation-induced plasticity may therefore be of great relevance for the treatment of neurodegenerative diseases, but remains largely unexplored. Here we show that a single torpor and arousal sequence in mice does not induce dendrite retraction and synapse loss as observed in seasonal hibernators. Instead, it increases hippocampal long-term potentiation and contextual fear memory. This is accompanied by increased levels of key postsynaptic proteins and mitochondrial complex I and IV proteins, indicating mitochondrial reactivation and enhanced synaptic plasticity upon arousal. Interestingly, a single torpor and arousal sequence was also sufficient to restore contextual fear memory in an APP/PS1 mouse model of Alzheimer’s disease. Our study demonstrates that torpor in mice evokes an exceptional state of hippocampal plasticity and that naturally occurring plasticity mechanisms during torpor provide an opportunity to identify unique druggable targets for the treatment of cognitive impairment.

scholarly journals Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xi Yin ◽  
Yuan Gao ◽  
Hai-Shui Shi ◽  
Li Song ◽  
Jie-Chao Wang ◽  
...  
Keyword(s):  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Hippocampal Ca1
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