What is the role of C-reactive protein and fecal calprotectin in evaluating Crohn's disease activity?

2019 ◽  
Vol 38-39 ◽  
pp. 101602 ◽  
Author(s):  
Christopher Ma ◽  
Robert Battat ◽  
Reena Khanna ◽  
Claire E. Parker ◽  
Brian G. Feagan ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Fecal Calprotectin ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

Serum Albumin and C-Reactive Protein/Albumin Ratio Are Useful Biomarkers of Crohn’s Disease Activity

2016 ◽  
Vol 22 ◽  
pp. 4393-4400 ◽  
Author(s):  
Guangming Qin ◽  
Jiangfeng Tu ◽  
Lingang Liu ◽  
Laisheng Luo ◽  
Jiaqi Wu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Serum Albumin ◽  
Disease Activity ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

scholarly journals Serum C-reactive protein level does not correlate with Crohn’s Disease Activity Index

2010 ◽  
Vol 5 ◽  
pp. 274-278
Author(s):  
Maciej Kohut ◽  
Katarzyna Kozioł ◽  
Emilia Olek ◽  
Anna Koclęga ◽  
Marek Hartleb
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Protein Level ◽  
Activity Index ◽  
Disease Activity Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

Platelet Activation Markers Are Associated with Crohn’s Disease Activity in Patients with Low C-Reactive Protein

2015 ◽  
Vol 60 (11) ◽  
pp. 3418-3423 ◽  
Author(s):  
Hiroshi Takeyama ◽  
Tsunekazu Mizushima ◽  
Hideki Iijima ◽  
Shinzaki Shinichiro ◽  
Mamoru Uemura ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Platelet Activation ◽  
C Reactive Protein ◽  
Activation Markers ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

scholarly journals TREATMENT OF ANEMIA AND IMPROVEMENT OF QUALITY OF LIFE AMONG PATIENTS WITH CROHN'S DISEASE: experience using ferric carboxymaltose

2015 ◽  
Vol 52 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Carlos Walter SOBRADO ◽  
Rodolfo Delfini CANÇADO ◽  
Lucas Faraco SOBRADO ◽  
Marcos Onofre FRUGIS ◽  
Marcel Faraco SOBRADO
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Iron Deficiency ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Ferric Carboxymaltose ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

Objectives - Anemia is the most common hematological alteration in patients with Crohn's disease, and is frequently related to intestinal inflammatory activity. Its cause is multifactorial and mostly associated with absolute iron deficiency (iron deficiency anemia) and/or functional iron deficiency (inflammation anemia or anemia of chronic disease). It may also be identified through other causes, such as folic acid or vitamin B12 deficiency and secondary to adverse effects from medications (salicylic derivatives and immunosuppressive drugs). In the present study, patients with active Crohn's disease and anemia were evaluated and treated with intravenous ferric carboxymaltose. We discuss the therapeutic schemes (doses), safety, results and improvement of quality of life. Methods - In the present prospective study, 10 consecutive patients with Crohn's disease, with moderate to severe activity, with anemia (Hb: 6.7 to 10 g/dL), who were attended between March 2014 and March 2015, were evaluated. Six (60%) were men and four were women, all with moderate or severe anemia (hemoglobin <10 g/dL). They were treated with a maximum of three intravenous infusions of 1000 mg of ferric carboxymaltose, of at least 15 minutes in duration. It was also sought to correlate the inflammatory Crohn's disease activity degree (measured using the Crohn's Disease Activity Index, CDAI) and C-reactive protein level with the severity of anemia. The primary outcome was an increase in Hb of ≥2 g/dL and the secondary outcome was the normalization of anemia (Hb ≥12 g/dL for women and ≥13 g/dL for men) and the improvement in quality of life seen 12 weeks after the last application of carboxymaltose. Results - Among the 10 patients studied, parenteral iron supplementation was administered in three cases during hospitalization and the others received this on an outpatient basis. The total iron dose ranged from 1,000 to 2,000 mg, with an average of 1,650 mg. Crohn's disease activity measured using CDAI and C-reactive protein correlated with the intensity of anemia. An increase of 2 g/dL occurred in eight (80%) patients after 12 weeks and normalization of anemia was found in seven (70%) patients. Improvements in quality-of-life scores were found for all (100%) patients after 12 weeks. Carboxymaltose was well tolerated. Three patients presented adverse reactions (two with nausea and one with headache) of mild intensity. Conclusions - Anemia is a frequent complication for Crohn's disease patients. Intravenous iron therapy has been recommended for Crohn's disease patients, because for these patients, oral iron absorption is very limited. This is because of the inflammatory state and "blocking" of iron entry into enterocytes through hepcidin action on ferroportin, along with the elevated rates of gastrointestinal adverse events that compromise adherence to treatment and possibly aggravate the intestinal inflammatory state. The degree of Crohn's disease activity, as measured using CDAI and C-reactive protein, correlates with the severity of anemia. Carboxymaltose is a safe drug, which can be administrated in high doses (up to 1,000 mg per application per week) and corrects anemia and iron stocks over a short period of time, with consequent improvement in quality of life.

scholarly journals Erratum to: Platelet Activation Markers Are Associated with Crohn’s Disease Activity in Patients with Low C-Reactive Protein

2015 ◽  
Vol 60 (12) ◽  
pp. 3827-3827
Author(s):  
Hiroshi Takeyama ◽  
Tsunekazu Mizushima ◽  
Hideki Iijima ◽  
Shinichiro Shinzaki ◽  
Mamoru Uemura ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Platelet Activation ◽  
C Reactive Protein ◽  
Activation Markers ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

Update on C-reactive protein and fecal calprotectin: are they accurate measures of disease activity in Crohn’s disease?

2019 ◽  
Vol 13 (4) ◽  
pp. 319-330 ◽  
Author(s):  
Christopher Ma ◽  
Robert Battat ◽  
Claire E. Parker ◽  
Reena Khanna ◽  
Vipul Jairath ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Fecal Calprotectin ◽  
C Reactive Protein ◽  
Reactive Protein
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