Marshall's nucleic acid: From double-helical structure to a potent intercalator

2021 ◽  
Vol 269 ◽  
pp. 106525
Author(s):  
Pradeep Pant ◽  
Maria Fisher
Keyword(s):  
Nucleic Acid ◽  
Helical Structure ◽  
Double Helical Structure

Introduction to DNA

2018 ◽  
pp. 1-10
Author(s):  
David Bensimon ◽  
Vincent Croquette ◽  
Jean-François Allemand ◽  
Xavier Michalet ◽  
Terence Strick
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Structural Properties ◽  
Helical Structure ◽  
3D Structures ◽  
Double Helical Structure ◽  
Dna And Rna

This chapter provides a quick introduction to the structural properties of nucleic acids (DNA and RNA). It describes the famed double-helical structure of DNA, the more complex 3D structures adopted by RNA, and the random (possibly) twisted coil that nucleic acid can display at large scales.

scholarly journals Living supramolecular polymerization of fluorinated cyclohexanes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Oleksandr Shyshov ◽  
Shyamkumar Vadakket Haridas ◽  
Luca Pesce ◽  
Haoyuan Qi ◽  
Andrea Gardin ◽  
...  
Keyword(s):  
Dipole Moment ◽  
Self Assembly ◽  
Materials Science ◽  
Helical Structure ◽  
The Self ◽  
Supramolecular Polymers ◽  
Aliphatic Compound ◽  
Double Helical Structure ◽  
Key Driver ◽  
Supramolecular Polymerization

AbstractThe development of powerful methods for living covalent polymerization has been a key driver of progress in organic materials science. While there have been remarkable reports on living supramolecular polymerization recently, the scope of monomers is still narrow and a simple solution to the problem is elusive. Here we report a minimalistic molecular platform for living supramolecular polymerization that is based on the unique structure of all-cis 1,2,3,4,5,6-hexafluorocyclohexane, the most polar aliphatic compound reported to date. We use this large dipole moment (6.2 Debye) not only to thermodynamically drive the self-assembly of supramolecular polymers, but also to generate kinetically trapped monomeric states. Upon addition of well-defined seeds, we observed that the dormant monomers engage in a kinetically controlled supramolecular polymerization. The obtained nanofibers have an unusual double helical structure and their length can be controlled by the ratio between seeds and monomers. The successful preparation of supramolecular block copolymers demonstrates the versatility of the approach.

scholarly journals Accurate Representation of B-DNA Double Helical Structure with Implicit Solvent and Counterions

2002 ◽  
Vol 83 (1) ◽  
pp. 382-406 ◽  
Author(s):  
Lihua Wang ◽  
Brian E. Hingerty ◽  
A.R. Srinivasan ◽  
Wilma K. Olson ◽  
Suse Broyde
Keyword(s):  
Helical Structure ◽  
Implicit Solvent ◽  
Accurate Representation ◽  
Double Helical Structure

Direct-to-Consumer Genetic Testing

2011 ◽  
pp. 51-84 ◽  
Author(s):  
Richard A. Stein
Keyword(s):  
Human Genome ◽  
Human Genome Project ◽  
Cost Effective ◽  
Helical Structure ◽  
Genome Project ◽  
Next Generation ◽  
Double Helical Structure ◽  
Sequencing Technologies ◽  
Human Genome Sequencing ◽  
The Human Genome Project

The 1953 discovery of the DNA double-helical structure by James Watson, Francis Crick, Maurice Wilkins, and Rosalind Franklin, represented one of the most significant advances in the biomedical world (Watson and Crick 1953; Maddox 2003). Almost half a century after this landmark event, in February 2001, the initial draft sequences of the human genome were published (Lander et al., 2001; Venter et al., 2001) and, in April 2003, the International Human Genome Sequencing Consortium reported the completion of the Human Genome Project, a massive international collaborative endeavor that started in 1990 and is thought to represent the most ambitious undertaking in the history of biology (Collins et al., 2003; Thangadurai, 2004; National Human Genome Research Institute). The Human Genome Project provided a plethora of genetic and genomic information that significantly changed our perspectives on biomedical and social sciences. The sequencing of the first human genome was a 13-year, 2.7-billion-dollar effort that relied on the automated Sanger (dideoxy or chain termination) method, which was developed in 1977, around the same time as the Maxam-Gilbert (chemical) sequencing, and subsequently became the most frequently used approach for several decades (Sanger et al., 1975; Maxam & Gilbert, 1977; Sanger et al., 1977). The new generations of DNA sequencing technologies, known as next-generation (second generation) and next-next-generation (third generation) sequencing, which started to be commercialized in 2005, enabled the cost-effective sequencing of large chromosomal regions during progressively shorter time frames, and opened the possibility for new applications, such as the sequencing of single-cell genomes (Service, 2006; Blow, 2008; Morozova and Marra, 2008; Metzker, 2010).

SPECTRAL CLASSIFICATION OF ARCHAEAL AND BACTERIAL GENOMES

2002 ◽  
Vol 10 (03) ◽  
pp. 233-241 ◽  
Author(s):  
SU-LONG NYEO ◽  
I-CHING YANG ◽  
CHI-HAO WU
Keyword(s):  
Dna Sequences ◽  
Power Spectra ◽  
Helical Structure ◽  
Spectral Classification ◽  
Bacterial Genomes ◽  
Denaturation Temperature ◽  
Noncoding Sequences ◽  
Double Helical Structure ◽  
Complete Genomes

The power spectra of the nucleotides in the coding and noncoding sequences of the complete genomes of twenty-two archaea and bacteria are obtained. According to the intensities at the periodicity of 3 bp in the spectra, it is observed that the genomic sequences may be classified into three types. Moreover, the spectra generally have a small but broad peak in the 10–11 bp periodicities. For the archaea, the peak is seen to locate preferably at about 10 bp periodicity, while for the bacteria, it tends to locate at about 11 bp. These features suggest that the DNA sequences of archaea generally have a tighter double helical structure than those of bacteria in order to cope with harsh environmental conditions. Besides, among the archaea, A. Pernixi K1 is found to have the largest periodicity of about 11 bp, but has a comparatively high CG content in its genome and hence a high denaturation temperature.

scholarly journals Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Mark Lukin ◽  
Tanya Zaliznyak ◽  
Francis Johnson ◽  
Carlos R. de los Santos
Keyword(s):  
Dna Adducts ◽  
Nmr Spectra ◽  
Room Temperature ◽  
Helical Structure ◽  
Environmental Pollutant ◽  
Synthetic Approach ◽  
Amino Groups ◽  
Double Helical Structure ◽  
Duplex Stability ◽  
Living Organisms

3-Nitrobenzanthrone (3NBA), an environmental pollutant and potent mutagen, causes DNA damage via the reaction of its metabolically activated form with the exocyclic amino groups of purines and the C-8 position of guanine. The present work describes a synthetic approach to the preparation of oligomeric 2′-deoxyribonucleotides containing a 2-(2′-deoxyguanosin-N2-yl)-3-aminobenzanthrone moiety, one of the major DNA adducts found in tissues of living organisms exposed to 3NBA. The NMR spectra indicate that the damaged oligodeoxyribonucleotide is capable of forming a regular double helical structure with the polyaromatic moiety assuming a single conformation at room temperature; the spectra suggest that the 3ABA moiety resides in the duplex minor groove pointing toward the 5′-end of the modified strand. Thermodynamic studies show that the dG(N2)-3ABA lesion has a stabilizing effect on the damaged duplex, a fact that correlates well with the long persistence of this damage in living organisms.

scholarly journals A Double-helical Structure for Re-aggregated Protein of Narcissus Mosaic Virus

1975 ◽  
Vol 29 (3) ◽  
pp. 325-330 ◽  
Author(s):  
D. J. Robinson ◽  
A. Hutcheson ◽  
P. Tollin ◽  
H. R. Wilson
Keyword(s):  
Mosaic Virus ◽  
Helical Structure ◽  
Double Helical Structure ◽  
Narcissus Mosaic Virus
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