Liquid-liquid phase separation of a monoclonal antibody at low ionic strength: Influence of anion charge and concentration

2017 ◽  
Vol 220 ◽  
pp. 7-19 ◽  
Author(s):  
Katharina Reiche ◽  
Josef Hartl ◽  
Alfred Blume ◽  
Patrick Garidel
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Ionic Strength ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
Low Ionic Strength ◽  
Liquid Liquid Phase Separation

Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation

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Author(s):  
Ronald W. Thompson ◽  
Ramil F. Latypov ◽  
Ying Wang ◽  
Aleksey Lomakin ◽  
Julie A. Meyer ◽  
...  
Keyword(s):  
Phase Separation ◽  
Ionic Strength ◽  
Liquid Phase ◽  
Colloidal Stability ◽  
Liquid Phase Separation ◽  
Effects Of Ph ◽  
Liquid Liquid Phase Separation

scholarly journals Investigating Liquid–Liquid Phase Separation of a Monoclonal Antibody Using Solution-State NMR Spectroscopy: Effect of Arg·Glu and Arg·HCl

2017 ◽  
Vol 14 (8) ◽  
pp. 2852-2860 ◽  
Author(s):  
Priscilla Kheddo ◽  
Jack E. Bramham ◽  
Rebecca J. Dearman ◽  
Shahid Uddin ◽  
Christopher F. van der Walle ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Nmr Spectroscopy ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
Solution State ◽  
Liquid Liquid Phase Separation

scholarly journals On the Aggregation and Nucleation Mechanism of the Monoclonal Antibody Anti-CD20 Near Liquid-Liquid Phase Separation (LLPS)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Elvira Pantuso ◽  
Teresa F. Mastropietro ◽  
Maria L. Briuglia ◽  
Charline J. J. Gerard ◽  
Efrem Curcio ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Nucleation Mechanism ◽  
Liquid Phase Separation ◽  
Anti Cd20 ◽  
Liquid Liquid Phase Separation

scholarly journals Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation

mAbs ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1940666
Author(s):  
Jack E. Bramham ◽  
Stephanie A. Davies ◽  
Adrian Podmore ◽  
Alexander P. Golovanov
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
High Concentration ◽  
Antibody Solution ◽  
Liquid Liquid Phase Separation

scholarly journals Liquid-Liquid Phase Separation of a Monoclonal Antibody and Nonmonotonic Influence of Hofmeister Anions

2010 ◽  
Vol 99 (11) ◽  
pp. 3792-3800 ◽  
Author(s):  
Bruce D. Mason ◽  
Jian Zhang-van Enk ◽  
Le Zhang ◽  
Richard L. Remmele ◽  
Jifeng Zhang
Keyword(s):  
Monoclonal Antibody ◽  
Phase Separation ◽  
Liquid Phase ◽  
Liquid Phase Separation ◽  
Hofmeister Anions ◽  
Liquid Liquid Phase Separation
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