Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI

2010 ◽  
Vol 152 (1-3) ◽  
pp. 99-108 ◽  
Author(s):  
Theo Luiz Ferraz de Souza ◽  
Daniel Sanches ◽  
Rafael Braga Gonçalves ◽  
Samuel Silva da RochaPita ◽  
Pedro Geraldo Pascutti ◽  
...  
Keyword(s):  
Hydrophobic Effect ◽  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Conformational Selection ◽  
Apoptosis Protein ◽  
Dynamic Restriction

Turner syndrome patients with bicuspid aortic valves and renal malformations exhibit abnormal expression of X-linked inhibitor of apoptosis protein (XIAP)

2015 ◽  
Vol 28 (11-12) ◽  
Author(s):  
Ganesh S. Jevalikar ◽  
Margaret Zacharin ◽  
Mary White ◽  
Steven W. Yau ◽  
Winnie Li ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Turner Syndrome ◽  
Quantitative Polymerase Chain Reaction ◽  
Inhibitor Of Apoptosis ◽  
Aortic Valves ◽  
Inhibitor Of Apoptosis Protein ◽  
Abnormal Expression ◽  
Apoptosis Protein ◽  
Renal Malformations ◽  
Bicuspid Aortic Valves

AbstractWe analyzed mRNA expression of X-linked inhibitor of apoptosis protein (XIAP) in patients with Turner syndrome (TS) and examined its association with phenotypic features.XIAP mRNA expression levels were investigated in 98 patients with TS in total RNA extracted from blood leucocytes by real time quantitative polymerase chain reaction.Levels of XIAP mRNA were significantly lower in patients with bicuspid aortic valves (BAV; n=13) than those without (log XIAP –1.17±0.3 vs. –0.94±0.2, p=0.002). Significantly higher expression of XIAP mRNA was seen in patients with a mosaic karyotype and renal malformations (log XIAP –0.79±0.3 vs. –1.0±0.3, p=0.03). No correlations were seen between XIAP and other manifestations.Abnormal expression of XIAP may be an important underlying mechanism in the development of BAV and renal malformations in TS. However, abnormal XIAP mRNA expression, as determined from peripheral mononuclear cells, does not appear to explain all the somatic and visceral stigmata of TS.

Genomic Characterization of the Mouse Inhibitor of Apoptosis Protein 1 and 2 Genes

Genomics ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 495-503 ◽  
Author(s):  
Peter Liston ◽  
Charles Lefebvre ◽  
Wai Gin Fong ◽  
Jian Ying Xuan ◽  
Robert G. Korneluk
Keyword(s):  
Inhibitor Of Apoptosis ◽  
Inhibitor Of Apoptosis Protein ◽  
Apoptosis Protein ◽  
Genomic Characterization
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