Assessing causal relationship from gut microbiota to heel bone mineral density

Bone ◽  
2021 ◽  
Vol 143 ◽  
pp. 115652
Author(s):  
Jing-Jing Ni ◽  
Xiao-Lin Yang ◽  
Hong Zhang ◽  
Qian Xu ◽  
Xin-Tong Wei ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gut Microbiota ◽  
Causal Relationship ◽  
Bone Mineral ◽  
Mineral Density ◽  
Heel Bone

98 GROUND REACTION FORCES OF POSTMENOPAUSAL WOMEN: INFLUENCE OF HEEL BONE MINERAL DENSITY AND REGIONAL SOFT LEAN MASS

Maturitas ◽  
2012 ◽  
Vol 71 ◽  
pp. S51
Author(s):  
M.H. Moreira ◽  
R.E. Gabriel ◽  
A. Leite ◽  
F.R. Aragão ◽  
J. Fonseca ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Lean Mass ◽  
Ground Reaction Forces ◽  
Mineral Density ◽  
Heel Bone ◽  
Reaction Forces

scholarly journals Assessing the Relationship Between Gut Microbiota and Bone Mineral Density

2020 ◽  
Vol 11 ◽  
Author(s):  
Shiqiang Cheng ◽  
Xin Qi ◽  
Mei Ma ◽  
Lu Zhang ◽  
Bolun Cheng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gut Microbiota ◽  
Bone Mineral ◽  
Mineral Density ◽  
The Relationship

scholarly journals Gut microbiota is associated with bone mineral density

2021 ◽  
Vol 10 (11) ◽  
pp. 734-741
Author(s):  
Bolun Cheng ◽  
Yan Wen ◽  
Xuena Yang ◽  
Shiqiang Cheng ◽  
Li Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gut Microbiota ◽  
Bone Mineral ◽  
Interaction Analysis ◽  
Population Based ◽  
Polygenic Risk Score ◽  
Regulation Mechanism ◽  
Mineral Density ◽  
Phospholipase D1 ◽  
The Individual

Aims Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD. Methods A total of 3,321 independent loci of gut microbiota were used to calculate the individual polygenic risk score (PRS) for 114 gut microbiota-related traits. The individual genotype data were obtained from UK Biobank cohort. Linear regressions were then conducted to evaluate the possible association of gut microbiota with L1-L4 BMD (n = 4,070), total BMD (n = 4,056), and femur total BMD (n = 4,054), respectively. PLINK 2.0 was used to detect the single-nucleotide polymorphism (SNP) × gut microbiota interaction effect on the risks of L1-L4 BMD, total BMD, and femur total BMD, respectively. Results We detected five, three, and seven candidate gut microbiota-related traits for L1-L4 BMD, total BMD, and femur BMD, respectively, such as genus Dialister (p = 0.004) for L1-L4 BMD, and genus Eisenbergiella (p = 0.046) for total BMD. We also detected two common gut microbiota-related traits shared by L1-L4 BMD, total BMD, and femur total BMD, including genus Escherichia Shigella and genus Lactococcus. Interaction analysis of BMD detected several genes that interacted with gut microbiota, such as phospholipase D1 ( PLD1) and endomucin ( EMCN) interacting with genus Dialister in total BMD, and COL12A1 and Discs Large MAGUK Scaffold Protein 2 ( DLG2) interacting with genus Lactococcus in femur BMD. Conclusion Our results suggest associations between gut microbiota and BMD, which will be helpful to further explore the regulation mechanism and intervention gut microbiota of BMD. Cite this article: Bone Joint Res 2021;10(11):734–741.

scholarly journals Identifying Pleiotropic SNPs Associated With Femoral Neck and Heel Bone Mineral Density

2020 ◽  
Vol 11 ◽  
Author(s):  
Pei He ◽  
Xiang-He Meng ◽  
Xiao Zhang ◽  
Xu Lin ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Mineral Density ◽  
Heel Bone
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