scholarly journals Baseline anthropometric indices predict change in vertebral size in early adulthood – A 10-year follow-up MRI study

Bone ◽  
2020 ◽  
Vol 138 ◽  
pp. 115506
Author(s):  
Petteri Oura ◽  
Juho-Antti Junno ◽  
Elsi Autio ◽  
Jaro Karppinen ◽  
Jaakko Niinimäki
Keyword(s):  
Early Adulthood ◽  
Anthropometric Indices ◽  
Mri Study

scholarly journals Changes in vertebral dimensions in early adulthood – A 10-year follow-up MRI-study

Bone ◽  
2019 ◽  
Vol 121 ◽  
pp. 196-203 ◽  
Author(s):  
Elsi Autio ◽  
Petteri Oura ◽  
Jaro Karppinen ◽  
Markus Paananen ◽  
Jaakko Niinimäki ◽  
...  
Keyword(s):  
Early Adulthood ◽  
Mri Study ◽  
Vertebral Dimensions

Anorectal Malformations and the Risk of Colorectal Cancer—Is Early Routine Endoscopic Screening Indicated?

2020 ◽  
Author(s):  
Anna Svenningsson ◽  
Anna Gunnarsdottir ◽  
Tomas Wester
Keyword(s):  
Colorectal Cancer ◽  
Early Adulthood ◽  
Anorectal Malformations ◽  
Population Based ◽  
Observational Period ◽  
Endoscopic Screening ◽  
Medical Birth Register ◽  
National Patient ◽  
And Gender

Abstract Introduction Colorectal cancer (CRC) has been reported in early adulthood in patients with anorectal malformation (ARM), and therefore, the need of endoscopic controls has been discussed. The aim of this study was to assess the risk of CRC in patients with ARM. Materials and Methods This was a nationwide population-based study with data from Swedish national health care registers. All patients diagnosed with ARM born in Sweden between 1964 and 1999 were identified in the National Patient Register. The same group was followed up in the Swedish Cancer Register from birth to December 31, 2014, for occurrences of CRC. Five age- and gender-matched individuals randomly selected from the Medical Birth Register served as controls for each ARM patient born between 1973 and 1999. Results A total of 817 patients (474 males) with ARM were included and followed up from birth to the end of observational period. Time of follow-up ranged from 15 to 50 years (mean: 28 years). None of the patients was diagnosed with CRC during the observational period. One case of rectal cancer and one case of sigmoid cancer were detected among the 3,760 controls. Conclusion In our study, the risk of CRC in early adulthood in patients with ARM is low. Our result does not support routine endoscopic follow-up for patients with ARM during the first decade of life.

Does Vertebral Body Tethering Cause Disc and Facet Joint Degeneration? A Preliminary MRI Study with Minimum 2-years Follow-up

2021 ◽  
Author(s):  
Altug Yucekul ◽  
Burcu Akpunarli ◽  
Atahan Durbas ◽  
Tais Zulemyan ◽  
Irem Havlucu ◽  
...  
Keyword(s):  
Vertebral Body ◽  
Facet Joint ◽  
Joint Degeneration ◽  
Facet Joint Degeneration ◽  
Mri Study

A Six-Year Follow-Up MRI Study of Complicated Early Childhood Convulsion

2006 ◽  
Vol 35 (4) ◽  
pp. 257-260 ◽  
Author(s):  
Tom F.D. Farrow ◽  
Jon M. Dickson ◽  
Richard A. Grünewald
Keyword(s):  
Early Childhood ◽  
Mri Study

PP40 An Ethnic Minority Cohort of Young People – Feasibility of follow-up in Early Adulthood?

2013 ◽  
Vol 67 (Suppl 1) ◽  
pp. A64.3-A65
Author(s):  
Z E Enayat ◽  
U M Read ◽  
O Molaodi ◽  
A Cassidy ◽  
S Harding
Keyword(s):  
Young People ◽  
Ethnic Minority ◽  
Early Adulthood

122. Does vertebral body tethering cause disc and facet joint degeneration? An MRI study with minimum two years of follow-up

2021 ◽  
Vol 21 (9) ◽  
pp. S60
Author(s):  
Altug Yucekul ◽  
Burcu Akpunarli ◽  
Atahan Durbas ◽  
Tais Zulemyan ◽  
Irem Havlucu ◽  
...  
Keyword(s):  
Vertebral Body ◽  
Facet Joint ◽  
Joint Degeneration ◽  
Facet Joint Degeneration ◽  
Mri Study

scholarly journals Long-term follow-up until early adulthood in autosomal dominant, complex SPG30 with a novel KIF1A variant: a case report

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Carlotta Spagnoli ◽  
Susanna Rizzi ◽  
Grazia Gabriella Salerno ◽  
Daniele Frattini ◽  
Carlo Fusco
Keyword(s):  
Autosomal Dominant ◽  
De Novo ◽  
Current Knowledge ◽  
Brain Mri ◽  
Early Adulthood ◽  
Cerebellar Atrophy ◽  
Mild Intellectual Disability ◽  
Long Term Follow Up

Abstract Background Pathogenic variants in KIF1A (kinesin family member 1A) gene have been associated with hereditary spastic paraplegia (HSP) type 30 (SPG30), encopassing autosomal dominant and recessive, pure and complicated forms. Case presentation We report the long-term follow-up of a 19 years-old boy first evaluated at 18 months of age because of toe walking and unstable gait with frequent falls. He developed speech delay, mild intellectual disability, a slowly progressive pyramidal syndrome, microcephaly, bilateral optic subatrophy and a sensory axonal polyneuropathy. Brain MRI showed cerebellar atrophy, stable along serial evaluations (last performed at 18 years of age). Targeted NGS sequencing disclosed the de novo c.914C > T missense, likely pathogenic variant on KIF1A gene. Conclusions We report on a previously unpublished de novo heterozygous likely pathogenic KIF1A variant associated with slowly progressive complicated SPG30 and stable cerebellar atrophy on long-term follow-up, adding to current knowledge on this HSP subtype.

scholarly journals Tumefactive Multiple Sclerosis Clinically Mimicking Acute Stroke and Lesional Migration Along the Biopsy Tract: A Case Report

2019 ◽  
Vol 19 (2) ◽  
pp. 148-153
Author(s):  
Oranan Tritanon ◽  
Arunee Singhsnaeh ◽  
Jiraporn Laothamatus ◽  
Atthaporn Boongird ◽  
Disya Ratanakorn ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Acute Stroke ◽  
Demyelinating Disease ◽  
Internal Capsule ◽  
Chronic Inflammatory Cell ◽  
Left Frontal Lobe ◽  
Lentiform Nucleus ◽  
Mri Study ◽  
Tumefactive Multiple Sclerosis

Tumefactive multiple sclerosis is a form of demyelinating disease which patient can present with acute stroke. We reported a case of a 49-year-old woman with well controlled hypertension, who presented with right hemiplegia 15 hours prior to admission. The initial diagnosis of acute stroke was made. Emergency computed tomography showed hypodense lesion at the left lentiform nucleus and posterior limb of the left internal capsule. The magnetic resonance imaging (MRI) study showed hyperintense FLAIR lesion in the left lentiform nucleus, left internal capsule, left thalamus, and periventricular area of the left frontoparietal region, some areas of restricted diffusion and inhomogeneous enhancement. The MR spectroscopy (MRS) of the lesion showed increased choline peak, decreased creatine and NAA peaks, and maximal choline to creatine ratio 2.25. Her symptoms deteriorated with progressive headache and motor aphasia. The follow up MRI showed extension of the inhomogeneous enhancing lesion along the biopsy tract at the left frontal lobe with the enhancing and MR spectra pattern similar to the lesion. The craniotomy with left frontal lesion excision included the mass and the biopsy tract was done. The lesion showed acute and chronic inflammatory cell infiltration with macrophages, necrotic tissue and reactive gliosis. The further pathological worked up demonstrated foci of demyelination with relative axonal preservation, numerous CD68+ macrophages with intracyto-plasmic Luxol fast blue(+) myelin debris. Perivascular and parenchymal CD3+ T-cells were identified, especially in demyelinating foci. These findings supported the diagnosis of tumefactive multiple sclerosis. Her conditions were improved after treating with pulse methylprednisolone and intravenous immunoglobulin (IVIG). Follow up MRI study 4 months after treatment revealed almost resolution of the preexisting inhomogeneous enhancing lesion.

scholarly journals Body Mass Index and Its Change from Adolescence to Adulthood Are Closely Related to the Risk of Adult Metabolic Syndrome in China

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Bingyang Liu ◽  
Yue Li ◽  
Jiamei Guo ◽  
Yuting Fan ◽  
Ling Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Glycosylated Hemoglobin ◽  
Early Adulthood ◽  
Study Groups ◽  
Relationship Of ◽  
Baseline Bmi ◽  
The Relationship

Aims. To investigate the influence of body mass index (BMI) and its change from adolescence to adulthood (ΔBMI) on the risk of metabolic syndrome (MetS) in early adulthood. Methods. We selected 931 students from 12 to 16 years of age in Liaoyang City, China. Ninety-three participants from 18 to 22 years of age with complete baseline data were available for follow-up after 5 years. Statistical analysis determined the relationship of MetS at follow-up with baseline BMI (BMIb), ΔBMI, and follow-up BMI (BMIf). Results. ΔBMI was positively correlated with the change of waist circumference (ΔWC), systolic blood pressure (ΔSBP), triglycerides (ΔTG), uric acid, and glycosylated hemoglobin (ΔHbA1c) in follow-up ( p < 0.05 ). For every 1 kg/m2 increase in BMIb, ΔBMI, and BMIf, the risk of MetS at follow-up increased 1.201-fold, 1.406-fold, and 1.579-fold, respectively. Both BMIb and ΔBMI were predictive of MetS at follow-up, with prediction thresholds of 23.47 kg/m2 and 1.95 kg/m2. The participants were divided by the predicted BMIb and ΔBMI threshold values into four study groups. Interestingly, the group with lower BMI but a higher increase in BMI presented the same metabolic derangements and Mets% of the group with higher BMI but lower Δ BMI. Conclusion. Both BMI of adolescence and ΔBMI were predictive of MetS and cardiovascular risk factors in adulthood. Control of both variables in adolescents would be more effective in decreasing the risk of MetS in young adults than control of BMI alone.

scholarly journals Use of Radiographic Criteria for Proximal Humeral Head Migration After Dislocation of the Shoulder to Identify Damage to Its Rotator Cuff

2019 ◽  
Vol 100 (2) ◽  
pp. 95-101
Author(s):  
A. P. Stepanchenko ◽  
G. V. Fedoruk ◽  
A. A. Makovskiy ◽  
V. E. Dubrov ◽  
R. V. Zaytsev ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Correlation Analysis ◽  
Humeral Head ◽  
Shoulder Dislocation ◽  
Older Patients ◽  
Subacromial Space ◽  
Rotator Cuff Injury ◽  
Mri Study ◽  
Mri Measurements

Objective. To assess whether radiographic criteria for proximal humeral head migration can be used as screening of damage to the rotator cuff after dislocation in patients over 45 years of age.Material and methods. The study included the results of a follow-up of 101 patients after shoulder dislocation without signs of damage to the rotator cuff before injury. Damage to the rotator cuff was assessed using MRI, followed by a correlation analysis between the results of measuring the height of the subacromial space with radiography and MRI.Results. Signs of cranial migration of the humeral head are detected statistically significantly more frequently in the group of older patients than in that of young ones (F=0.009; p<0.05). MRI study statistically significantly more often revealed signs of damage to the rotator cuff in the older patients than in the young ones (F=0.009; p<0.05). There was a high correlation between the humeral head migration index and the MRI measurements of the acromiohumeral interval (r=0.93, p<0.05).Conclusion. The acromiohumeral index, as well as MRI, can be used as a criterion for rotator cuff injury. This study has shown that the older patients have a 19-fold higher risk for damage to the rotator cuff from a dislocated shoulder (95% CI 6.93–52.11). Thus, attention should be paid to the presence of radiographic signs of rotator cuff injury in all patients after dislocation of the shoulder.

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